Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery

Gong, Jianping; Liu, Yang; Huang, Xin-En; Sun, Beicheng; Zhou, Jian; Yu, Dongsheng; Zhou, Xin; Li, Dong-Zheng; Guan, Xin; Wang, Dongfeng

doi:10.7314/apjcp.2014.15.2.707

Cited by 39 publications

(31 citation statements)

References 35 publications

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“…Data are presented as means ± standard deviation (SD). We have enough experience in conducting medical researches, and have published some results elsewhere Dai et al, 2013;Deng et al, 2013;Gu et al, 2013;Fei et al, 2013;Shen et al, 2013;Sun et al, 2013;Wei et al, 2013;Yan et al, 2013;Gong et al, 2014;Zhang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

Ji¹,

Liu²,

Ju³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

Ji¹,

Liu²,

Ju³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Anastomotic leak after colorectal surgery increases postoperative morbidity, mortality, length of hospital stay, and nosocomial infection rates, and decreases quality of life (18,25,26). Moreover, anastomotic leak after colorectal cancer surgery may result in poor functional and oncological outcomes (27).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

Aghayeva

Benlice

Bilgin

et al. 2017

Tumori

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Introduction Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model. Methods Sixty Wistar albino rats were employed in the study. Sigmoid resection and end-to-end colorectal anastomosis was performed in all rats. Group 1 rats underwent the surgical procedure alone, while group 2 rats were given hyperthermic intraperitoneal lavage with heated saline following surgery. Groups 3, 4, 5, and 6 had surgery with concomitant HIPEC treatment with mitomycin C, cisplatin, oxaliplatin, and doxorubicin, respectively. Anastomotic bursting pressures and hydroxyproline levels were evaluated. Results Regarding the hydroxyproline levels, groups 1 and 2 showed significantly higher values than other groups (p<0.001). However, there was no significant difference between the HIPEC treatment groups (groups 3, 4, 5, and 6) (p>0.05). When groups were compared regarding bursting pressure values, no significant differences were observed (p = 0.81). Conclusions This study demonstrated that the HIPEC procedure with mitomycin C, cisplatin, oxaliplatin and doxorubicin had negative effects on hydroxyproline levels, but had no detrimental effect on anastomotic bursting pressure in a rat model.

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“…Stata version 8.0 (StatSoft Inc., Tulsa, OK) was used to analyze data. We have enough experience in conducting medical researches, and have published some results elsewhere Wei et al, 2013;Wu et al, 2013;Gong et al, 2014;Lu et al, 2014;Xiao et al, 2014;Xu et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A Predictive Model for Evaluating Responsiveness to Pemetrexed Treatment in Patients with Advanced Colorectal Cancer

Wu¹,

Huang²,

Cao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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. Nevertheless, many patients still failed to treatment due to tumor recurrence and metastasis, and 5-year survival rate still less than 10%.Pemetrexed is a new anticancer drug. 2 by 10 minute infusion on day 1, repeated every 3 weeks. Doses were modified depending on nadir counts of blood cells. Combined chemotherapeutic agents included irinotecan, lobaplatin, carboplatin, oxaliplatin, gemcitabine, cis-platinum or bevacizumab. Multiple variables (age, sex, hemoglobin, platinum drugs combined, metastasis sites, LDH, ALP, CEA>40 ug/ml) reported earlier were selected.We used logistic regression analysis to evaluate relationships between these and tumor response. Results: On multivariable analysis, we found that age was significant in predicting the responsiveness to pemetrexed (p<0.05) combined with oxaliplatin. We did not find any other factors which were significantly associated with the response rate to chemotherapy with pemetrexed and irinotecan. Conclusions: By multivariate analysis, we found that age had significant impact on the responsiveness of pemetrexed when combined with oxaliplatin. Additional research based on genomic properties of host and tumors are needed to clarify markers for better selection of patients who could benefit from pemetrexed combined chemotherapy.

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Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery

Cited by 39 publications

References 35 publications

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

A Predictive Model for Evaluating Responsiveness to Pemetrexed Treatment in Patients with Advanced Colorectal Cancer

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