Outer retinal deformity detected by optical coherence tomography in eyes with foveal hypoplasia

Katagiri, Satoshi; Yamaguchi, Tadashi; Mikami, Masashi; Nishina, Sachiko; Azuma, Noriyuki

doi:10.1007/s00417-016-3385-z

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…[44] Katagiri et al . [45] reported that different OCT images of Henle's fiber layer reflected different grades of foveal maturity with regard to the visual acuity in eyes with aniridia and isolated foveal hypoplasia.…”

Section: Diseases Known To Be Associated With Foveal Hypoplasia Beformentioning

confidence: 99%

Foveal hypoplasia and optical coherence tomographic imaging

Kondo

2018

Taiwan J Ophthalmol

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Foveal hypoplasia is a retinal disorder in which there is a lack of full development of the morphology of the fovea. The optical coherence tomography (OCT) and functional findings are presented in relation to the underlying genetic and developmental conditions. Recent advancements of high-resolution OCT imaging have unveiled characteristics of foveal hypoplasia that were not detected by conventional imaging methods. An absence of a foveal pit does not necessarily imply poor visual acuity, and the maturation of the cone photoreceptors is important for the visual acuity. Regardless of the degree of the development of the inner retinal layers, the visual acuity can be preserved as in diseases such as Stickler syndrome that is a newly identified retinal disorder associated with foveal hypoplasia.

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Section: Diseases Known To Be Associated With Foveal Hypoplasia Beformentioning

confidence: 99%

Foveal hypoplasia and optical coherence tomographic imaging

Kondo

2018

Taiwan J Ophthalmol

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“…The patient demographics were analyzed using the two-tailed and non-paired t -tests for the age at examination or chi-square test for gender. Each measurement parameter between eyes with ONH and controls was analyzed using the mixed effect model for repeated measurements following the previous study 29 . The other parameters included the GCC thickness and that from the INL to the RPE in each macular region, optic disc area, RNFL thickness and that from the INL to the RPE in each circumpapillary region, and each component of the FF-ERG and FM-ERG amplitudes and implicit times.…”

Section: Statistical Analysesmentioning

confidence: 99%

Retinal Structure and Function in Eyes with Optic Nerve Hypoplasia

Katagiri

Nishina

Yamaguchi

et al. 2017

Sci Rep

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We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were performed. SD-OCT analysis of the macular region showed significant ganglion cells complex (GCC) thinning nasally and temporally (P < 0.05), but the thickness from the inner nuclear layer (INL) to the retinal pigment epithelium (RPE) became thinner only nasally (P < 0.05). SD-OCT analysis of the circumpapillary region showed significant thinning in the retinal nerve fiber layer and from the INL to the RPE (P < 0.05). The horizontal SD-OCT images showed variable foveal abnormalities. FF-ERG analysis showed significantly reduced amplitudes (P < 0.05) and preserved implicit time in the photopic negative response. The amplitudes and implicit times of the other FF-ERG components did not differ significantly. FM-ERG analysis showed significantly reduced amplitudes (P < 0.05) but preserved implicit times in all components. The current study showed the change of retinal structure and function in eyes with ONH compared with those with control, representing by decreased retinal ganglion cells (RGCs) and their axons, foveal abnormalities, and preserved peripheral retina except for the RGCs and their axons.

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“…Foveal hypoplasia (FH) refers to underdevelopment of the fovea, characterized by the continuity of inner retinal layers in the presumed foveal area; the foveal avascular zone may be limited or absent, and retinal vessels may be seen coursing through the foveal region. 1,2 It is commonly associated with ocular conditions such as aniridia, albinism, achromatopsia, or a PAX6 mutation. 3 Less commonly, isolated foveal hypoplasia (IFH) may occur.…”

Section: Discussionmentioning

confidence: 99%

“…10 Mantle cell lymphoma: conjunctival mass in a female patient Mantle cell lymphoma (MCL) is a rare neoplasm in the ocular adnexa, accounting for 3%-5% of conjunctival B-cell non-Hodgkin lymphomas (NHL). 1,2 Conjunctival MCL typically presents in male patients in the eighth decade and is often advanced at the time of presentation. 3 Treatment typically consists of chemotherapy or radiation, although the prognosis is poor.…”

Section: Discussionmentioning

confidence: 99%