2024
DOI: 10.1126/sciadv.adl0165
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Outlook and opportunities for engineered environments of breast cancer dormancy

Nathan R. Richbourg,
Ninette Irakoze,
Hyuna Kim
et al.

Abstract: Dormant, disseminated breast cancer cells resist treatment and may relapse into malignant metastases after decades of quiescence. Identifying how and why these dormant breast cancer cells are triggered into outgrowth is a key unsolved step in treating latent, metastatic breast cancer. However, our understanding of breast cancer dormancy in vivo is limited by technical challenges and ethical concerns with triggering the activation of dormant breast cancer. In vitro models avoid many of these challenges by simul… Show more

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Cited by 6 publications
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