Outstanding drug loading capacity by water stable microporous MOF: a potential drug carrier

Abstract

A robust, highly water stable (up to 3 weeks), microporous MOF, [Zn8(O)2(CDDB)6(DMF)4(H2O)] {where CDDB = 4,4'-(9-H carbazole-3,6-diyl)dibenzoic acid}, was synthesized based on an open N-H site by a solvothermal process and exhibited an outstanding loading capacity (around 53.3 wt%) and satisfactory release capability (64.9% and 81.9%) for 5-fluorouracil, constituting a negligible cytotoxicity effect.

Zr‐Based MOFs with High Drug Loading for Adsorption Removal of Anti‐Cancer Drugs: A Potential Drug Storage

“…For drug adsorption, delivery and other biomedical applications, cell cytotoxicity is one of the main important factors which should be considered when developing new materials . Therefore, before using these nanoparticles for drug adsorption, the cellular toxicity experiments were performed on the HFF2 cell line with different concentrations of various MOFs.…”

“…The second step of release could be defined as a slow and steady process, which took as long as 60 hr, because of the normal desorption of drug molecules from the pores of MOFs, diffusion and consequently dissolution in release medium. This observation might be attributed to the different host‐guest interactions between the adsorbents and the adsorbate molecules, including hydrogen bonds and л‐л interaction of the organic ligands of the adsorbent frameworks with the aromatic structure of MTX and CUR drugs (see Figure S4) …”

“…This observation might be attributed to the different host-guest interactions between the adsorbents and the adsorbate molecules, including hydrogen bonds and л-л interaction of the organic ligands of the adsorbent frameworks with the aromatic structure of MTX and CUR drugs (see Figure S4). [2,45,48,49] As shown in Figure S4, the interaction between drug molecules and MOF nanoparticles via hydrogen bonding increased with raising the number of polar functional T A B L E 3 Comparison the maximum adsorption capacities of MTX and CUR onto the synthesized adsorbents with different adsorbents reported in literature…”

“…For drug adsorption, delivery and other biomedical applications, cell cytotoxicity is one of the main important factors which should be considered when developing new materials. [2,36,[44][45][46][47] Therefore, before using these nanoparticles for drug adsorption, the cellular toxicity experiments were performed on the HFF2 cell line with different concentrations of various MOFs. As can be depicted from Figure 6, the cytotoxicity of the synthesized MOFs increased with increasing the concentration from 35 to 560 μg/ml, and the cytotoxicity of UiO-66-NH 2 decreased by functionalization with GMA and EDA.…”

High-Throughput Molecular Simulations of Metal Organic Frameworks for CO2 Separation: Opportunities and Challenges

“…They have exceptional physical properties such as very large surface areas [the highest reported one with 6,411 m 2 /g (Grunker et al, 2014)], high pore volumes (1-4 cm 3 /g), a large variety of pore sizes, and good stabilities. MOFs have been used in a wide range of chemical applications (Mueller et al, 2006) including gas storage and gas separation (Sun et al, 2013;Zornoza et al, 2013;Adatoz et al, 2015;, catalysis (Gascon et al, 2014), sensing (Zhu et al, 2013;Muller-Buschbaum et al, 2015), drug storage, and delivery (Della Rocca et al, 2011;Keskin and Kizilel, 2011;Bag et al, 2016). Gas separation has been the most widely examined application since MOFs offer a large variety in their pore sizes, shapes and chemistries.…”