OvAge: a new methodology to quantify ovarian reserve combining clinical, biochemical and 3D-ultrasonographic parameters

Venturella, Roberta; Lico, Daniela; Sarica, Alessia; Falbo, Maria; Gulletta, Elio; Morelli, Michele; Zupi, Errico; Cevenini, Gabriele; Cannataro, Mario; Zullo, Fulvio

doi:10.1186/s13048-015-0149-z

Cited by 31 publications

(27 citation statements)

References 23 publications

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“…The main outcomes were differences between control group (BPS) and intervention group (BTS) regarding ovarian reserve parameters including AMH, FSH, AFC, PSV, VI, FI, VFI as well as calculated ovarian age (OvAge/ year) from the following formula OVAge = 48.05 -3.14 AMH + 0.07 FSH -0.77 AFC -0.11 FI + 0.25 VI + 0.1 AMH x AFC + 0.02 FSH x AFC (24,25) at one year after performed tubal sterilizing procedure at time of cesarean delivery (CD). The subsidiary outcomes were related to operational feasibility as well as surgical consequences of tubal sterilizing procedures including operative time as well as total and tubal procedure related estimated blood loss, blood transfusion and related organs injuries.…”

Section: Methodsmentioning

confidence: 99%

Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Elnory

Elmantwe

2019

Evidence Based Women's Health Journal

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Aim of the work: The objective of this trial was to compare between bilateral total salpingectomy (BTS) as a theoretically more effective ovarian cancer (OvCa) risk-reducing primary prevention and bilateral partial salpingectomy (BPS) [stander tubal ligation (STL)] procedures at time of cesarean section (CS) for parturients who completed their reproductive desire and requesting permanent sterilization regard to the impacts of both procedures on ovarian reserve parameters at one year post-sterilization as well as the surgical consequences of both procedures. Patients and Methods: This is a prospective, randomized, open-label, concealed allocation, parallel group, superiority trial was conducted at three surgical sites in El-Qulobia, Egypt including Benha University Hospital, Obstetrics and Gynecology Department between October 2015 and October 2017. 120 parturients undergoing CS were allocated to BTS (intervention group) (60) and BPS (control group) (60). Main outcomes were one year post-sterilization differences in ovarian reserve (OR) parameters including hormonal as well as two-dimensional and three-dimensional transvaginal ultrasonographic parameters ; namely, anti-müllerian hormone (AMH) (ng/ml), follicular stimulating hormone (FSH) (mIu/ml), peak systolic velocity (PSV) (cm/s), antral follicle count (AFC) (n), vascular index (VI) (%), flow index (FI) (0-100), vascular flow index (VFI) (0-100), calculated ovarian age [OvAge (year)] and ovarian volume. Ancillary outcomes were surgical feasibility and surgical consequences. Results: 102 women completed the one-year follow up (85%), 50 in the BTS group and 52 in the BPS group and there were no statistically significant differences regarding the ovarian reserve parameters at one year post-sterilization including AMH, FSH, AFC, VI, FI, VFI OvAge and ovarian volume (P > 0.05). Also, there were no statistically significant differences regarding items included in surgical. consequences comparison (P > 0.05) as well as surgical sterilization feasibility (100% vs 100%, p = 1). Also, there were no apparent complications due to sterilization procedures in both groups. Conclusion: Impacts of bilateral total salpingectomies (BTS) on ovarian reserve as sterilizing procedure during cesarean section as well as rates of surgical consequences are similar with that of bilateral partial salpingectomies (BPS) (STL). So, BTS could be recommended over BPS (STL) for women completing their reproductive desire, despite its better efficacy as ovarian cancer reducing surgery as well as its better clinical and sterilizing efficacy remained to be elucidated. .

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Section: Methodsmentioning

confidence: 99%

Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Elnory

Elmantwe

2019

Evidence Based Women's Health Journal

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“…Furthermore, recently, some authors validated a new mathematical tool to predict ovarian age, using some hormonal and ultrasonographic parameters. Using multiplanar and inversion mode 3D, they showed that AFC is a reliable marker for ovarian reserve, but did not compared to 2D; in addition, the sample was composed mainly by fertile patients [6]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of three-dimensional SonoAVC ultrasound for antral follicle count in infertile women: its agreement with conventional two-dimensional ultrasound and serum levels of anti-Müllerian hormone

Fagundes

Chapon

Olsen

et al. 2017

Reprod Biol Endocrinol

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BackgroundSeveral studies have reported a correlation between antral follicle count by conventional 2D transvaginal sonography and serum anti-Müllerian hormone levels. However, few studies have investigated the effectiveness of 3D SonoAVC transvaginal ultrasound technology, particularly in infertile women. Therefore, this study aims to evaluate the usefulness of three-dimensional (3D) SonoAVC transvaginal ultrasound technology for antral follicle count and its correlation to conventional two-dimensional (2D) transvaginal ultrasound and serum levels of anti-Müllerian hormone in infertile women.MethodsThis cross-sectional study included 42 infertile women with age lower than 40 years that underwent treatment at a private fertility clinic between June and December 2015. Patient data included age, body mass index and cause of infertility. On cycle day 3 the following hormone levels were measured: serum levels of anti-Müllerian hormone, follicle-stimulating hormone, cancer antigen 125, prolactin, thyroid-stimulating hormone and oestradiol; the number of antral follicles was counted as well. The scanning were performed through 2D and 3D technology transvaginal ultrasound.ResultsUsing a Bland-Altman test we demonstrated that both technologies are quite equivalent. However, antral follicle count is higher using 3D ultrasound technology compared to 2D technology (p < 0.001; Wilcoxon test), this finding is mainly remarkable in ovaries with more than 20 antral follicles. Moreover, the mean time required for manual 2D ultrasound and 3D SonoAVC measurements were 275 ± 109 and 103 ± 57 s, respectively (p < 0.001). Serum AMH concentration correlated to the total number of early antral follicles (correlation coefficients = 0.678 and 0.612; p < 0.001 by 2D ultrasound and 3D SonoAVC, respectively; Spearman’s correlation test).ConclusionsAntral follicle count is better estimated using 3D ultrasound compared to 2D technology. A great advantage of 3D SonoAVC was less time required for an examination and the visual advantage when it need to count more than 20 follicles.Trial registration CAAE: 35141114.4.0000.5327. Registered 10 June 2015.

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“…Scientists and clinicians are joining forces in a synergistic effort to improve the effectiveness of infertility care by introducing novel therapeutic protocols for the purpose of customising care and improving cost-effectiveness, for example, by adopting New frontiers in human assisted reproduction -from research to clinical practice: Several considerations (Review) different formulations of gonadotropins according to different cohorts of patients and the IVF setting (6,7), testing novel drugs (for example, introducing recombinant luteinising hormone) and formulations (e.g. long-acting gonadotropins), and searching for novel markers for estimating biological age (8,9), and novel nomograms to optimise the yield of a controlled ovarian hyper-stimulation cycle. On the other hand, political, social and health institutions are doing little to educate young women with respect to disinformation and to increase their awareness regarding age as the predominant factor that contributes towards the decline in fertility.…”

Section: Introductionmentioning

confidence: 99%

New frontiers in human assisted reproduction - from research to clinical practice: Several considerations

Gizzo

Noventa

Quaranta

et al. 2016

Molecular Medicine Reports

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In the era of very late, or advanced, motherhood, in which 'egg banks', 'social' egg‑freezing, egg donation and surrogacy represent a potential solution to a number of obstacles to human reproduction, what is the role of scientists and clinicians involved in assisted reproduction? In light of the apprehension that, in the future, through fertility treatment infertility may be passed on to the offspring, boundaries of medical vs. 'social' infertility are being created. Scientists and clinicians are joining forces in a synergistic effort to improve the effectiveness of infertility care by introducing novel therapeutic protocols with the intent of customising care and improving cost‑effectiveness, testing novel drugs and formulations, and searching for novel markers (for estimating biological age) and nomograms (to optimise the yield of a controlled ovarian hyperstimulation cycle). On the other hand, political, social and health institutions are doing little to educate young women with respect to disinformation and to increase their awareness regarding age as the predominant factor that contributes towards the decline in fertility. Nevertheless, despite the great advances that have been made, 38 years after the birth of the first baby via in vitro fertilisation, the intricate road leading from the antral follicle to the fully developed baby continues to be designated as being too 'expensive', 'empirical', 'mysterious' or 'bound by ethics', with few significant improvements in terms of real cost‑effectiveness.

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OvAge: a new methodology to quantify ovarian reserve combining clinical, biochemical and 3D-ultrasonographic parameters

Cited by 31 publications

References 23 publications

Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Impact of bilateral total salpingectomy versus standard tubal ligation at time of cesarean section on ovarian reserve: A randomized controlled trial

Evaluation of three-dimensional SonoAVC ultrasound for antral follicle count in infertile women: its agreement with conventional two-dimensional ultrasound and serum levels of anti-Müllerian hormone

New frontiers in human assisted reproduction - from research to clinical practice: Several considerations

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