2019
DOI: 10.1111/petr.13372
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Ovarian function after allogeneic hematopoietic stem cell transplantation in children and young adults given 8‐Gy total body irradiation‐based reduced‐toxicity myeloablative conditioning

Abstract: Background The spectrum of late sequelae after hematopoietic stem cell transplantation (HSCT) includes infertility, which is the most frequent complication. Some reports suggested that ovarian function may be better preserved in females undergoing HSCT with reduced‐intensity conditioning (RIC) than with conventional myeloablative conditioning (MAC). However, the impact of HSCT after 8‐Gy TBI‐based reduced‐toxicity MAC (RTMAC), whose efficacy is between those of conventional MAC and RIC, on ovarian function rem… Show more

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Cited by 9 publications
(6 citation statements)
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“…Overall, these reports are in line with our results, however, longer follow-up is required to evaluate whether the lower incidence in our most recent cohorts will be balanced with time from HSCT. Interestingly, a lower incidence of ovarian insufficiency of 36% (5/14) was described following a protocol of 8 Gy TBI to 14 female patients with hematological malignancies (33). This is of potential importance to the up-coming FORUM 2 study, in which patients are likely to be randomized to conditioning with 8 versus 12 Gy TBI in combination with etoposide.…”
Section: Discussionmentioning
confidence: 99%
“…Overall, these reports are in line with our results, however, longer follow-up is required to evaluate whether the lower incidence in our most recent cohorts will be balanced with time from HSCT. Interestingly, a lower incidence of ovarian insufficiency of 36% (5/14) was described following a protocol of 8 Gy TBI to 14 female patients with hematological malignancies (33). This is of potential importance to the up-coming FORUM 2 study, in which patients are likely to be randomized to conditioning with 8 versus 12 Gy TBI in combination with etoposide.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, a lower incidence of ovarian insufficiency of 36% (5/14) was described following a protocol of 8 Gy TBI delivered to 14 female patients with hematological malignancies. 33 This is of potential importance to the upcoming FORUM 2 study, in which patients are likely to be randomized to conditioning with 8 Gy versus 12 Gy TBI in combination with etoposide.…”
Section: Discussionmentioning
confidence: 99%
“…Patients presenting for fertility preservation prior to HSCT should be counseled about these risks, as they may affect their decision‐making about oocyte cryopreservation. Changes to conditioning protocols, including reduced‐intensity conditioning (RIC) regimens or ovarian shielding during TBI, have been found to be protective for ovarian function, 79,80 and would likely confer some uterine protection as well, although this has not been specifically studied. Additionally, umbilical uterine transposition has been reported in select cases 81,82 .…”
Section: Radiation‐induced Uterine Injurymentioning
confidence: 99%