Ovarian Metastasis from Thyroid Carcinoma 12 Years After Partial Thyroidectomy Mimicking Struma Ovarii

Young, Robert H.; Jackson, Alan; Wells, Michael

doi:10.1097/00004347-199404000-00012

Cited by 64 publications

(31 citation statements)

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“…The rarity of ovarian metastasis from DTC is supported by a review of the literature, where only three cases have been reported (Young et al 1994, Logani et al 2001, Brogioni et al 2007. It seems that ovarian metastasis tends to occur unilaterally rather than bilaterally (Fig.…”

Section: Ovarian Metastasismentioning

confidence: 93%

Rare metastases of differentiated thyroid carcinoma: pictorial review

Song

Xue²,

Xu³

et al. 2011

Endocrine-Related Cancer

131

148

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Differentiated thyroid cancer (DTC) is usually indolent with good prognosis and long-term survival. However, DTC distant metastasis is often a grave event and accounts for most of its diseasespecific mortality. The major sites of distant metastases are the lung and bone. Metastases to the brain, breast, liver, kidney, muscle, and skin are rare or relatively rare. Nevertheless, recognizing rare metastases from DTC has a significant impact on the clinical decision making and prognosis of patients.131 I single photon emission computed tomography/computed tomography ( 131 I-SPECT/CT) can provide both metabolic and anatomic information about a lesion; therefore, it can better localize and define the 131 I-WBS findings in DTC patients. In this pictorial review, the imaging features of a range of rare metastases from DTC are demonstrated, with a particular emphasis on the 131 I-SPECT/CT diagnostic aspect.

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Section: Ovarian Metastasismentioning

confidence: 93%

Rare metastases of differentiated thyroid carcinoma: pictorial review

Song

Xue²,

Xu³

et al. 2011

Endocrine-Related Cancer

131

148

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“…Thyrotoxicosis from functional ectopic thyroid tissue occurs in about 5-15% of cases [2]. Although in general, benign, malignant transformation of the tumor is reported in 0.1-0.3% of cases [3]. Overall prevalence estimates are confounded by the fact that reports of malignant struma ovarii in the older literature may actually have been examples of strumal carcinoid.…”

Section: Introductionmentioning

confidence: 99%

RAS Mutation-Positive Follicular Variant of Papillary Thyroid Carcinoma Arising in a Struma Ovarii

Coyne

Nikiforov

2009

Endocr Pathol

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Struma ovarii is an ovarian mature teratoma composed exclusively or predominantly of thyroid tissue. Malignant transformation of struma ovarii is rare and poorly understood, although this process is thought to be similar to carcinogenesis in malignant tumors of differentiated thyroid tissue originating in the thyroid gland. Genetic alterations in the mitogen-activated protein kinase pathway, including mutations of BRAF, RAS, and RET genes, have been implicated in the development of differentiated thyroid carcinoma arising in the thyroid gland. We report here a case with RAS mutation detected in a malignant struma ovarii. The patient is a 38-year-old female who had a 2.4 cm ovarian cyst noted incidentally on a first trimester ultrasound. She proceeded to ovarian cystectomy post-delivery, with pathologic examination detecting a papillary thyroid carcinoma, follicular variant, arising in a cystic teratoma. The tumor was tested for BRAF, RAS, and RET/PTC mutations. HRAS codon 61 mutation was identified. This is the first report of RAS mutation detected in the follicular variant of papillary carcinoma arising in a struma ovarii. It provides evidence that tumors developing in this setting involve molecular mechanisms similar to those implicated in tumors developing in the thyroid gland.

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“…22 Moreover, papillary carcinoma of the thyroid with distant metastasis is very rare. Although distant metastases of differentiated thyroid carcinomas have been reported, including the porta hepatitis, 23 greater omentum, suprarenal glands, intra-abdominal lymph nodes, 24 liver, 25,26 kidney, prostate, 26 and others, 27 we were not able to find any report of gallbladder metastasis of thyroid carcinomas. We investigated whether our patient may have had distant metastasis to the gallbladder of follicular or papillary carcinomas of the thyroid.…”

Section: Discussionmentioning

confidence: 57%