Ovarian morphology after prolonged use of steroid contraceptive agents

Maqueo, M; Rice-Wray, E; Calderón, Juan José Arechederra; Goldzieher, Joseph W.

doi:10.1016/0010-7824(72)90044-3

Cited by 19 publications

(3 citation statements)

References 12 publications

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“…Cortical fibrosis has also been observed in physiological pregnancy. Maqueo et al (1972) reported an increase of connective tissue in almost all their 19 depo-progesogens treated patients with moderate to marked cortical fibrosis; this was presumed reversible. It may be a matter of interpretation but to us it seems more a condensation of fibrous tissue than a true increase at cortical level.…”

Section: Metabolic Changesmentioning

confidence: 99%

Long‐acting Injectable Progestogens in Human Fertility Control

Zañartu

Onetto

1972

Aust NZ J Obst Gynaeco

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Section: Metabolic Changesmentioning

confidence: 99%

Long‐acting Injectable Progestogens in Human Fertility Control

Zañartu

Onetto

1972

Aust NZ J Obst Gynaeco

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“…None of these 60 women revealed any fresh corpora lutea. In addition to this more or less pronounced inhibition of the follicular development, several authors have described a thickening of tunica albuginea (2, 10,18,21) and perifollicular fibrosis (4, 10, 14, 18, 25) during long-term treatment with oral contraceptives. Only Ludwig (8) and Mall-Haefeli et al (9) have in a few cases observed apparently fresh corpora lutea during the first 2 months of treatment, but the activity of these corpora lutea was not normal, since the urinary excretion of pregnanediol was low.…”

mentioning

confidence: 99%

“…The literature has been critically reviewed, and we found only 10 studies with an adequate description of the development of ovarian follicles during treatment (8,9,10,14,15,18,19,21,24,25). The literature has been critically reviewed, and we found only 10 studies with an adequate description of the development of ovarian follicles during treatment (8,9,10,14,15,18,19,21,24,25).…”

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confidence: 99%

Ovarian Morphology and Pituitary Gonadotrophins in Serum During and After Long‐Term Treatment with Oral Contraceptives

Starup

Visfeldt

1974

Acta Obstet Gynecol Scand

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The aim of the present investigation was to directly correlate the development of ovarian follicles with the levels of FSH and L H in serum during long-term treatment with oral contraceptives in order to discover to what extent follicular maturation beyond the stage of early primary follicles depends upon stimulation with pituitary gonadotropins.Seventeen women aged 20 to 44 were treated cyclically for 6 to 100 months with different oral contraceptives of the combination type. Group I (10 women) were examined during treatment, while group I1 (7 women) were examined within the first 7 weeks after cessation of treatment. Laparotomy was performed in all cases, and FSH and L H in serum were determined radioimmunologically shortly before the operation. The ovaries were inspected macroscopically, and large wedge excisions were submitted to histological examination.During treatment the values of serum FSH were low, but within the normal range in all women. The values of serum L H were very low in the normal range or even below the lower limit. The number of primordial follicles seemed to be mainly dependent on the age of the individual woman, whereas no correlation with the duration of treatment was found. All women except one revealed primary follicles in different stages of development. More surprising was the fact that 5 out of the 10 women showed antral and/or Graafian follicles in spite of the low levels of FSH and LH. No fresh corpora lutea were found. Two women showed a slight thickening of tunica albuginea, but in no case was perifollicular fibrosis found.Within the first 7 weeks after treatment 6 out of the 7 women revealed antral and/or Graafian follicles, and 2 of them a fresh corpus luteum. In addition, all val-

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The Ovary

Lipsett¹,

Ross²

1979

Contemporary Endocrinology

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Ovarian morphology after prolonged use of steroid contraceptive agents

Cited by 19 publications

References 12 publications

Long‐acting Injectable Progestogens in Human Fertility Control

Long‐acting Injectable Progestogens in Human Fertility Control

Ovarian Morphology and Pituitary Gonadotrophins in Serum During and After Long‐Term Treatment with Oral Contraceptives

The Ovary

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