Ovarian pregnancy

Boronow, Richard C.; McElin, Thomas W.; West, Robert H.; Buckingham, John C.

doi:10.1016/0002-9378(65)90708-8

Cited by 58 publications

(6 citation statements)

References 43 publications

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“…First, the embryo or blastocyst may migrate in retrograde through the tube and implant in the ovary. Second, it may pass into one of the puncture sites created by the aspiration needle ( Boronow et al, 1965 ). During the fresh cycle, ovarian injury after oocyte retrieval may provide an opportunity for ectopic implantation ( Ishihara et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Concurrent Ovarian and Tubal Ectopic Pregnancy After IVF-ET: Case Report and Literature Review

Huang

Liu

et al. 2022

Front. Physiol.

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Ovarian pregnancy (OP) coupled with tubal ectopic pregnancy is rare. We present a case of coexistent ovarian and tubal ectopic pregnancies in the same adnexa resulting from in vitro fertilization and embryo transfer (IVF-ET) for tubal occlusion. The patient presented with mild vaginal bleeding without abdominal pain. OP was diagnosed via sonographic findings of an ectopic gestational sac (GS) and yolk sac that seemed to be inside her left ovary. Laparoscopic exploration confirmed this diagnosis, and ipsilateral tubal ectopic pregnancy was suspected during surgery. The patient underwent left salpingectomy and resection of the ovarian lesion. A subsequent histopathological examination verified the diagnosis of coexistent ovarian and tubal ectopic pregnancy. Though the mechanism underlying concurrent OP and tubal ectopic pregnancy is still unclear, clinicians should be cautious of potential combined ectopic pregnancy when dealing with patients who have received more than one embryo transfer.

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Section: Discussionmentioning

confidence: 99%

Concurrent Ovarian and Tubal Ectopic Pregnancy After IVF-ET: Case Report and Literature Review

Huang

Liu

et al. 2022

Front. Physiol.

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“…Also, Campbell et al (1974) recommended that a check for occult ovarian pregnancy be made in cases of acute hemoperitoneum, especially if an IUD were present. Various aetiological mechanisms have been proposed by Boronow et al (1965): obstructive ovulation, e.g. pelvic inflammatory disease; ineffective tubal function; favourable surface phenomena, e.g.…”

Section: Discussionmentioning

confidence: 99%

Primary unruptured ovarian pregnancy with intrauterine device

Saber

1977

Postgraduate Medical Journal

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“…Histopathologically-confirmed OEP can be classified as intrafollicular or extrafollicular, the second form having two subtypes, however the clinical implication is controverted [ 31 ].…”

Section: ⧉ Histopathological and Immunohistochemical Examinationsmentioning

confidence: 99%

Ovarian ectopic pregnancy: the role of complex morphopathological assay. Review and case presentation

Istrate-Ofiţeru

Ruican

Niculescu³

et al. 2021

Rom J Morphol Embryol

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Ovarian ectopic pregnancy (OEP) represents the rarest type of ectopic pregnancy, accounting for 1-3% of this pathology. The diagnosis of this pathology is challenging due to the non-specific clinical aspects and the ultrasound examination hampered by the lack of visible gestational sac in the presence of hematocele and hemoperitoneum. The purpose of the extended histopathological (HP) examination was to identify particular aspects of the OEP trophoblast and to highlight potential local ovarian modifications which can determine pregnancy fixation at this level. The patient presented local favorable conditions for intraovarian nidation, conditions confirmed by the HP classical examination and by the immunohistochemical evaluation. We identified, using classical Hematoxylin-Eosin, Masson's trichrome and Periodic Acid-Schiff (PAS)-Hematoxylin, necrotic hemorrhage, accentuated vascular thrombosis and high density lymphoplasmocytary infiltrate. These modifications increased local adhesivity and cell destruction through hypoperfusion. Anti-cluster of differentiation antibodies (CD34, CD38, tryptase) revealed the low number of intravillous vessels and the high number of macrophages and mastocytes involved in the local inflammatory process heighten. We identified the presence of trophoblast tissue in the ovarian structure using anti-cytokeratin AE1/AE3 (CK AE1/AE3)/anticytokeratin 7 (CK7) antibodies. The anti-alpha-smooth muscle actin (α-SMA) and anti-vimentin (VIM) antibodies displayed the density of myofibroblasts and intravillous stromal cells and with the aid of anti-progesterone receptor (PR) antibody, we identified the corpus luteum hormonal response in the OEP. The placental villosities present a blocked multiplication process at the anti-apoptotic B-cell lymphoma 2 (BCL2) protein, confirmed by the Ki67 cell proliferation and tumor protein 63 (p63) immunomarkers. Anti-neuron specific enolase (NSE), anticalretinin and anti-inhibin A antibodies showed the particular aspects of the granulosa and internal theca cells, which may be involved in oocyte release blockage, intraluteal and extraluteal fecundation of the OEP.

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Ovarian pregnancy

Cited by 58 publications

References 43 publications

Concurrent Ovarian and Tubal Ectopic Pregnancy After IVF-ET: Case Report and Literature Review

Concurrent Ovarian and Tubal Ectopic Pregnancy After IVF-ET: Case Report and Literature Review

Primary unruptured ovarian pregnancy with intrauterine device

Ovarian ectopic pregnancy: the role of complex morphopathological assay. Review and case presentation

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