Ovarian Steroid Cell Tumour: Correlation of Histopathology with Clinicopathologic Features

Mehdi, Ghazala; Ansari, Hena A; Sherwani, Rana K; Rahman, Khaliqur; Akhtar, Nishat

doi:10.4061/2011/987895

Cited by 23 publications

(31 citation statements)

References 8 publications

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“…The chemotherapy regimen and outcome were not available for 1 patient [11] . Of the remaining 5, including ours, 2 experienced recurrence, and 3 are alive without recurrence [9,12,14,16] .…”

Section: Discussionmentioning

confidence: 99%

“…The review by Hayes and Scully [1] was published in 1987 and, since then, there have been no review articles or large case series on malignant SCTs, only case reports. Therefore, we reviewed the relatively recent literature (published since 1998) concerning malignant SCTs, in order to reevaluate the effectiveness of postsurgical adjuvant therapy and the clinical outcome in each patient [6,9,[10][11][12][13][14][15][16] . The clinicopathological factors, adjuvant therapies used, and outcomes in 12 reported patients, including the case in this study, are described in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

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Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Kosaka¹,

Hasegawa²,

Kiuchi³

et al. 2017

Acta Cytologica

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Background: Ovarian steroid cell tumors (SCTs) are rare and usually benign, although 25-43% are reportedly malignant. The cytologic findings of these rare ovarian tumors have almost never been reported. Case: We report a rare case of a malignant ovarian SCT with peritoneal dissemination and malignant ascites in a 40-year-old woman. Her tumor was classified as stage IIB (pT2bNoM0) according to the FIGO (International Federation of Gynecology and Obstetrics) classification system, and she was treated with adjuvant chemotherapy following staging laparotomy. Cytology of the ascitic fluid revealed large, polygonal-to-round cells and multinucleated cells with atypia, appearing in clusters with slight overlapping or as isolated tumor cells. Numerous tumor cells had small central round or eccentric nuclei with conspicuous nucleoli, and a moderate-to-abundant amount of cytoplasm, varying from granular and eosinophilic to pale and multivacuolated (foamy), with cannibalism formations. The nuclear chromatin was fine and granular, with irregular distribution and nuclear-membrane thickening. Conclusion: These may be the first reported cytology results for ascites with a malignant SCT. Our patient's cytological ascitic findings, rather than the histopathologic features of the original and disseminated tumors, represent the malignant features of the tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Kosaka¹,

Hasegawa²,

Kiuchi³

et al. 2017

Acta Cytologica

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“…Treatment of these tumours is decided on the basis of the staging, the extra-ovarian spread of the tumour and the desire to preserve fertility [8,9] . Unilateral salpingoophorectomy is the treatment of choice in young patients, as they are desirious of preserving fertility [10] .…”

Section: Discussionmentioning

confidence: 99%

Steroid cell tumour- NOS of the ovary in a young female

Patwardhan

Taware

Sathe

2018

APALM

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The patient, 22 year old, married since 3 years presented with history of primary infertility and excessive hair growth with change in the voice. She had history of oligomenorrhea and noted decrease in the size of the breast. There was no other significant past medical or surgical history. On general examination, vital parameters were within normal limits. Hirsutism was present. Genital examination revealed the presence of Clitoromegaly. Laboratory investigations revealed S. Androstenedione levels of more than 10ng/ml (Range: 0.3-2 ng/ml) and the level of S. Testosterone was 6.79 ng/ml (Range: 0.15-0.7 ng/ml). S. FSH level was 6.8 miu/ml (Range: 2.3-18.5 miu/ ml), S. LH level was 7.95 miu/ml (Range: 0.4-105 miu/ml) while S. ACTH level was 21.2 pg/ml (Range: 5-27 pg/ml). MRI Pelvis revealed right ovary measuring 4.6 X 4.4 X 3.4 cm which showed a focal lesion in the ovarian stroma. The left ovary was normal. Patient underwent right salpingooophorectomy with left ovarian drilling. Pranav Pramod Patwardhan*, Annapurna Chandrashekhar Taware and Pragati Aditya SatheDepartment of Pathology, Seth G S Medical College, Mumbai, India ABSTRACTSex cord stromal cell tumours constitute 5-8 % of all ovarian neoplasms. Steroid cell tumours are a type of sex cord stromal cell tumours. The name "Steroid cell" stands for the morphology and the functionality of these tumours. Steroid cell tumours-Not otherwise specified constitute about 56% of all steroid cell tumours and presents more commonly with androgenic manifestations in third to fourth decade.We present a case, 22 year old, who presented with virilizing symptoms. MRI was suggestive of an right ovarian mass for which right salpingo-oophorectomy was done. Histopathology revealed features classical of Steroid cell tumour-Not otherwise specified. We present the case for a relatively younger age at presentation and the classical histomorphology.

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“…The best recognized ones are surface epithelial cell tumours. Among the less common variants, lipid or steroid cell tumours comprise an important category, despite accounting for only 0.1% of all ovarian tumours (3).…”

Section: Sumáriomentioning

confidence: 99%

Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman

Souto

Baptista²,

Barreto³

et al. 2012

Arq Bras Endocrinol Metab

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SUMMARYVirilising ovarian tumours are a rare cause of hyperandrogenism in women, accounting for less than 5% of all ovarian neoplasms. It occurs most often in -and postmenopausal women. We report a case of a 64 year-old woman with signs of virilisation that had started 3 years before. Blood hormone analysis revealed increased levels of testosterone, and 17-hydroxyprogesterone. The tetracosactin test revealed 21-hydroxylase deficiency. Radiological imaging demonstrated a nodule in her left ovary. The patient was submitted to bilateral laparoscopic oophorectomy, and histopathological examination revealed a luteoma of the left ovary. Postoperative serum testosterone level and 17-hydroxyprogesterone returned to normal levels in one month. Virilism regressed within six months. Our patient also showed an elevation in 17-OHP serum levels. Normalization of 17-OHP after oophorectomy suggests a case of intratumoral 21-hydroxylase deficiency. To our knowledge, this is the first description of ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal woman. Arq Bras Endocrinol Metab. 2012;56(9):672-6 SUMáRioTumores ovarianos virilizantes são uma causa rara de hiperandrogenismo em mulheres, contabilizando menos de 5% de todos as neoplasias ovarianas. Esses tumores ocorrem mais comumente em mulheres em peri ou pós-menopausa. Relatamos aqui o caso de uma mulher de 64 anos de idade com sintomas de virilização que começaram 3 anos antes. O perfil hormonal revelou níveis aumentados de testosterona e de 17-hidroxiprogesterona (17-OHP). O teste de tetracosactin demonstrou deficiência de 21-hidroxilase. Exames radiológicos mostraram um nódulo no ovário esquerdo. A paciente foi submetida à ooforectomia laparoscópica bilateral e o exame histopatológico revelou um luteoma no ovário esquerdo. A concentração sérica de testosterona e de 17-hidroxiprogesterona após a cirurgia retornou aos níveis normais em um mês. A virilização regrediu em 6 meses. Nossa paciente também revelou uma elevação dos níveis séricos de 17-OHP. A normalização da 17-OHP após a ooforectomia sugere um caso de deficiência de 21-hidroxilase intratumoral. Esta é a primeira descrição de deficiência de 21-hidroxilase intratumoral em uma mulher na pós-menopausa. Arq Bras Endocrinol Metab. 2012;56(9):672-6

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Ovarian Steroid Cell Tumour: Correlation of Histopathology with Clinicopathologic Features

Cited by 23 publications

References 8 publications

Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Cytological Findings of Ascitic Fluid with a Malignant Ovarian Steroid Cell Tumor: A Case Report and Literature Review

Steroid cell tumour- NOS of the ovary in a young female

Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman

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