Ovarian theca cell

Magoffin, Denis A.

doi:10.1016/j.biocel.2005.01.016

Cited by 211 publications

(163 citation statements)

References 9 publications

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“…In normal ovary, the follicle is a basic functional unit containing an oocyte and granulosa cells enclosed by a basal lamina (33). Theca cells are thought to be recruited from stroma and differentiate only surrounding the lamina of developing follicles (34). After ovulation, theca cells are luteinized in corpus luteum.…”

Section: Discussionmentioning

confidence: 99%

“…Androgens serve as substrates for estrogens synthesis by granulosa cells. Theca and granulosa cells are two principle steroid hormone-producing cells and are mutually dependent in differentiation with robust paracrine communications (34). Theca cells are originated from stromal stem cells that differentiate under the stimulation by a number of peptide factors secreted from granulosa cells (33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

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Human Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations

Peng¹,

Zhang

Jaafar

et al. 2013

Journal of Biological Chemistry

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Background: GT198 is a tumor suppressor gene in breast and ovarian cancer. Results: Tumor stromal cells in various types of human ovarian cancer carry GT198 mutations and express theca cell-specific enzyme CYP17. Conclusion: GT198 mutant tumor stromal cells are luteinized theca cells in ovarian cancer. Significance: Studying mutant tumor stromal cells is crucial for understanding the cause of ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Human Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations

Peng¹,

Zhang

Jaafar

et al. 2013

Journal of Biological Chemistry

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“…The ovaries of 2-day-old mice are devoid of distinct follicular structures, and when the follicles grow to enclose two to three layers of granulosa cells, theca cells start to surround the follicles and acquire the steroidogenic ability regulated primarily by LH. Androstenedione, a steroid hormone produced by theca cells, is converted into estradiol by granulosa cells (1,2). Thus, folliculogenesis is a complex process in which germ cells (oocytes) and two types of somatic cells (theca cells and granulosa cells) interact through paracrine or direct mechanisms.…”

Section: Differentiation Of Putative Thecal Stem Cells In Vitro and Imentioning

confidence: 99%

“…From the preantral stage onward, theca cells differentiate as the outer layer of the follicle. These elements provide structural integrity and the androgen substrate for granulosa cell estrogen production, thus playing an indispensable role in follicular development (1). Mature theca cells can be distinguished by their morphology and location in situ and can be isolated easily in a crude suspension for in vitro analysis.…”

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confidence: 99%

Isolation, characterization, andin vitroandin vivodifferentiation of putative thecal stem cells

Honda

Hirose

Hara

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

123

115

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Although ovarian theca cells play an indispensable role in folliculogenesis by providing follicular structural integrity and steroid substrates for estrogen production, little information is available about their recruitment, growth, and differentiation because their immature forms have not been identified. We have isolated putative thecal stem cells with the ability to self-renew and differentiate in vivo and in vitro. They are similar to fibroblasts in morphology and proliferate in vitro as round colonies with a homogenous cell population. They were induced to differentiate into early precursors and steroidogenic cells in a stepwise manner after treatment with serum, luteinizing hormone, and paracrine factors from granulosa cells. At each differentiation step, these cells displayed appropriate gene expression and morphological markers and later secreted androstenedione. The fully mature morphology was achieved by coculture with isolated granulosa cells. When transplanted into the ovaries, the putative thecal stem cells colonized exclusively in the ovarian interstitium and the thecal layer of follicles as differentiated cells. Thus, thecal stem cells appear to be present in neonatal ovaries and can be isolated, purified, and induced to differentiate in vitro. Thecal stem cells could provide an invaluable in vitro experimental system to study interactions among the oocytes, granulosa cells, and theca cells during normal folliculogenesis and to study ovarian pathology caused by theca cell dysfunction.follicle ͉ oocyte ͉ ovary

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“…No steroidogenic cells were detectable in this biopsy, which is the logical consequence of the arrested follicular growth at the primary stage. A sterodogenic theca interna starts forming at a more advanced stage of follicular development, and becomes detectable only in secondary follicles with at last three layers of granulosa cells (Magoffin, 2005).…”

Section: Page 9 Of 40mentioning

confidence: 99%

Molecular pathology of the FSH receptor: New insights into FSH physiology

Meduri

Bachelot

Cocca

et al. 2008

Molecular and Cellular Endocrinology

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Please cite this article as: Meduri, G., Bachelot, A., Cocca, M.P., Vasseur, C., Rodien, P., Kuttenn, F., Touraine, P., Misrahi, M., Molecular Pathology of the FSH receptor: new insights into FSH physiology, Molecular and Cellular Endocrinology (2007), doi:10.1016/j.mce.2007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Ovarian theca cell

Cited by 211 publications

References 9 publications

Human Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations

Human Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations

Isolation, characterization, andin vitroandin vivodifferentiation of putative thecal stem cells

Molecular pathology of the FSH receptor: New insights into FSH physiology

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