Over-expression of vitronectin correlates with impaired survival in gastric cancers

Gong, Chao; Hong, Hai-feng; Xie, Jing-Feng; Xue, Yifeng; Huang, Yudian; Zhang, Dekun

doi:10.1097/md.0000000000026766

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…The relationship between GLRX and GC remains unknown. VTN overexpression was associated with poor prognosis for GC (Gong et al, 2021), while our results showed that VTN was downregulated. The relationship between NUTF2 and tumor progression also remains unclear.…”

Section: Discussionmentioning

confidence: 45%

Serum proteomic profiling of precancerous gastric lesions and early gastric cancer reveals signatures associated with systemic inflammatory response and metaplastic differentiation

Gong,

Lou,

Han

et al. 2024

Front. Mol. Biosci.

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The noninvasive detection technique using serum for large-scale screening is useful for the early diagnosis of gastric cancer (GC). Herein, we employed liquid chromatography mass spectrometry to determine the serum proteome signatures and related pathways in individuals with gastric precancerous (pre-GC) lesions and GC and explore the effect of Helicobacter pylori (H. pylori) infection. Differentially expressed proteins in GC and pre-GC compared with non-atrophic gastritis (NAG) group were identified. APOA4, a protein associated with metaplastic differentiation, and COMP, an extracellular matrix protein, were increased in the serum of patients with pre-GC lesions and GC. In addition, several inflammation-associated proteins, such as component C3, were decreased in the GC and pre-GC groups, which highlight a tendency for the inflammatory response to converge at the gastric lesion site during the GC cascade. Moreover, the abundance of proteins associated with oxidant detoxification was higher in the GC group compared with that in the NAG group, and these proteins were also increased in the serum of the H. pylori-positive GC group compared with that in the H. pylori-negative GC patients, reflecting the importance of oxidative stress pathways in H. pylori infection. Collectively, the findings of this study highlight pathways that play important roles in GC progression, and may provide potential diagnostic biomarkers for the detection of pre-GC lesions.

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Section: Discussionmentioning

confidence: 45%