Overexpression of Stat3 increases circulating cfDNA in breast cancer

Wang, Yifei; Wang, Xuejian; Lü, Zhong; Liu, Shurong; Yu, Jiang; Wan, Xiao-Qing; Cheng, Cong-Cong; Shi, Lihong; Wang, Lihua; Ding, Yi

doi:10.1007/s10549-021-06142-6

Cited by 3 publications

(4 citation statements)

References 49 publications

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“… 48 To date, the gold standard treatment for BCRL is the CDT, a comprehensive rehabilitation program including skin care, MLD, multilayer compression bandaging, and lympho-kinetic exercises. 32 , 49 , 50 On the other hand, KT has been recently proposed to have a role in BCRL management with growing literature supporting its advantages in BCRL care. To date, the impact of KT in the complex rehabilitation management of BCRL women is far from being fully characterized.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of kinesio taping on upper limb volume reduction in patients with breast cancer-related lymphedema: a systematic review of randomized controlled trials

Marotta

Lippi

Ammendolia

et al. 2023

Eur J Phys Rehabil Med

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INTRODUCTION One of the most common disabling complications in breast cancer (BC) patients is breast cancer-related lymphedema (BCRL), a pathological condition affecting both physical and psychological function, with detrimental consequences on health-related quality of life (HR-QoL). Rehabilitation has a key role in the comprehensive management of this condition with several studies reporting positive results after performing complex decongestive therapies (CDT) in these women. Kinesio taping (KT) is a rather recent therapeutic approach to treat BCRL, however, evidence in literature regarding its effectiveness is far from being fully characterized. Therefore, this systematic review aimed at assessing the role of KT among the CDT to treat BCRL. EVIDENCE ACQUISITION PubMed, Scopus, and Web of Science were systematically searched from inception until May 5 th , 2022 to determine randomized control trials (RCTs) reporting patients with BCRL; KT as intervention; limb volume as outcome (PROSPERO number: CRD42022349720). EVIDENCE SYNTHESIS Out of the documents identified, 123 were eligible for data screening, and only 7 RCTs satisfied the eligibility criteria and were included. We found that KT might have a positive effect on limb volume reduction in patients with BCRL, albeit there is little evidence for low quality of the included studies. CONCLUSIONS Taken together, this systematic review showed that KT did not significantly reduce the upper limb volume in BCRL women, albeit it seemed to increase the flow rate during the passive exercise. Further high-quality-studies are mandatory to improve the knowledge in order to include the KT might into a multidisciplinary rehabilitative approach for the management of BC survivors affected by lymphedema.

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Section: Discussionmentioning

confidence: 99%

“… 27 - 31 This novel rehabilitation technique has been developed by Dr. Kenzo Kase and consists of elastic adhesive tape that might promote the activation of blood microcirculation and lymphatic drainage through the elevation of the skin and facilitating passage of lymph to the vascular system. 32 …”

Section: Introductionmentioning

confidence: 99%

Efficacy of kinesio taping on upper limb volume reduction in patients with breast cancer-related lymphedema: a systematic review of randomized controlled trials

Marotta

Lippi

Ammendolia

et al. 2023

Eur J Phys Rehabil Med

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“…Identifying the factors determining ctDNA release is as paramount as challenging. A study investigated whether Stat3, an oncogene involved in the development of metastatic breast cancer cells, affected the release of ctDNA in mouse blood [35]. Three models of BALB/c nude mice were orthotopically xenografted with mouse breast cancer 4T1 cells expressing different levels of Stat3 (4T1-GFP control group, 4T1-Knockout-Stat3 group and 4T1-Overexpress-Stat3 group).…”

Section: Exploring the Determinants Of Ctdna Releasementioning

confidence: 99%

“…The study by Wang et al-previously mentioned for ctDNA-also tested the impact of Stat3 expression on CTCs. As for ctDNA, Stat3 was identified as a determinant of CTCs release, potentially regulated by Snail induction and associated with EMT changes [35].…”

Section: Ctcs In Xenograftsmentioning

confidence: 99%

Basic Science with Preclinical Models to Investigate and Develop Liquid Biopsy: What Are the Available Data and Is It a Fruitful Approach?

Cena

Melloul

Demartines

et al. 2022

IJMS

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The molecular analysis of circulating analytes (circulating tumor-DNA (ctDNA), -cells (CTCs) and -RNA (ctRNA)/exosomes) deriving from solid tumors and detected in the bloodstream—referred as liquid biopsy—has emerged as one of the most promising concepts in cancer management. Compelling data have evidenced its pivotal contribution and unique polyvalence through multiple applications. These data essentially derived from translational research. Therewith, data on liquid biopsy in basic research with preclinical models are scarce, a concerning lack that has been widely acknowledged in the field. This report aimed to comprehensively review the available data on the topic, for each analyte. Only 17, 17 and 2 studies in basic research investigated ctDNA, CTCs and ctRNA/exosomes, respectively. Albeit rare, these studies displayed noteworthy relevance, demonstrating the capacity to investigate questions related to the biology underlying analytes release that could not be explored via translational research with human samples. Translational, clinical and technological sectors of liquid biopsy may benefit from basic research and should take note of some important findings generated by these studies. Overall, results underscored the need to intensify the efforts to conduct future studies on liquid biopsy in basic research with new preclinical models.

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