Overexpression of the Long Noncoding RNA HIF2PUT Inhibits Non-Small Cell Lung Cancer Cell Proliferation and Invasion Through HIF-2a Pathway

Wang, Jingmin; Tian, Yingxuan; Yu, Min; Ma, Manman; Gao, Yanbin

doi:10.1089/cbr.2020.4629

Cited by 1 publication

(1 citation statement)

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“…277 Wang et al demonstrated that lncRNA HIF2PUT was downregulated in NSCLC tissues and cell lines, and its overexpression inhibits NSCLC proliferation and invasion via HIF-2α pathway. 278 Hypoxia signaling in gastric cancer (GC). GC is a high concern for health globally and the second cause of cancer deaths after LC.…”

Section: Neoplastic Diseasesmentioning

confidence: 99%

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Luo

Tian

Yang³

et al. 2022

Sig Transduct Target Ther

183

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Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is linked to several biological processes, including pathogenic microbe infection, metabolic adaptation, cancer, acute and chronic diseases, and other stress responses. The mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during hypoxia. Hypoxia-inducible factors (HIFs) sense hypoxia to regulate the expressions of a series of downstream genes expression, which participate in multiple processes including cell metabolism, cell growth/death, cell proliferation, glycolysis, immune response, microbe infection, tumorigenesis, and metastasis. Importantly, hypoxia signaling also interacts with other cellular pathways, such as phosphoinositide 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) signaling, nuclear factor kappa-B (NF-κB) pathway, extracellular signal-regulated kinases (ERK) signaling, and endoplasmic reticulum (ER) stress. This paper systematically reviews the mechanisms of hypoxia signaling activation, the control of HIF signaling, and the function of HIF signaling in human health and diseases. In addition, the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted, which would provide novel strategies for the design and development of therapeutic drugs.

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Section: Neoplastic Diseasesmentioning

confidence: 99%