Rutin is a well-known flavonoid found in a plethora of fruits and vegetables and has powerful biological activities which includes antioxidant, anti-inflammatory, antiplatelet, hypoglycemic, neuroprotective, antithrombic, cardioprotective, renal protective, and hepatoprotective to name just a few. In this chapter, we highlight the recent endeavours over the five past years for the sensing of rutin and offer insights to future research.