Overt social interaction and resting state in young adult males with autism: core and contextual neural features

Jasmin, Kyle; Gotts, Stephen J.; Xu, Yisheng; Liu, Siyuan; Riddell, Cameron; Ingeholm, John E.; Kenworthy, Lauren; Wallace, Gregory L.; Braun, Allen R.; Martin, Alex

doi:10.1093/brain/awz003

Cited by 42 publications

(57 citation statements)

References 104 publications

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“…This study identified very similar regions to those found in our analysis. These regions have been shown in the past to be involved in mentalizing and in theory of mind 22,[46][47][48][49] . Right TPJ in particular has long been thought to be fundamental for theory of mind [50][51][52] , whereas left TPJ, MPFC, ACC, PCC and IFG, have all been found to activate for various mentalizing and theory of mind tasks (see Schurz et al 53 for a meta-analysis).…”

Section: Discussionmentioning

confidence: 99%

“…Of the remaining 62, a subset of 36 males were chosen to match the ASD group, based on gender, age, IQ and motion. Mean age for the matched TD group was 20.8 (range [15][16][17][18][19][20][21][22][23][24][25][26][27][28]. For the eye movement analyses, three participants from the ASD group and two from the TD group were excluded for failing to achieve adequate calibration on the eye tracker.…”

Section: Participantsmentioning

confidence: 99%

“…Social deficits and impairments in social processing are among the defining characteristics of ASD 18 . For adolescents and young adults on the high functioning end of the spectrum however, these manifest most consistently as deficits in complex mentalizing or theory of mind tasks, though these deficits can be subtle and difficult to probe experimentally [19][20][21][22] . These difficulties also extend to social orienting.…”

Section: Introductionmentioning

confidence: 99%

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Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Ramot

Walsh

Reimann

et al. 2019

Preprint

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Extensive study of typically developing individuals and those on the autism spectrum has identified a large number of brain regions associated with our ability to navigate the social world. Although it is widely appreciated that this so-called 'social brain' is composed of distinct, interacting systems, these component parts have yet to be clearly elucidated. Here we used measures of eye movement and neural typicality -based on the degree to which subjects deviated from the norm -while typically developing (N = 62) and individuals with autism (N = 36) watched a large battery of movies depicting social interactions. Our findings provide clear evidence for distinct, but overlapping, neural systems underpinning two major components of the 'social brain', social orienting and inferring the mental state of others.

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Section: Discussionmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Ramot

Walsh

Reimann

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…This study identified very similar regions to those found in our analysis. These regions have been shown in the past to be involved in mentalizing and in theory of mind 26,[49][50][51][52] . Right TPJ in particular has long been thought to be fundamental for theory of mind [53][54][55] , whereas left TPJ, MPFC, ACC, PCC, and IFG, have all been found to activate for various mentalizing and theory of mind tasks (see Schurz et al 56 for a meta-analysis).…”

Section: Discussionmentioning

confidence: 99%

“…Social deficits and impairments in social processing are among the defining characteristics of ASD 22 . For adolescents and young adults on the high functioning end of the spectrum however, these manifest most consistently as deficits in complex mentalizing or theory of mind tasks, although these deficits can be subtle and difficult to probe experimentally [23][24][25][26] . These difficulties also extend to social orienting.…”

mentioning

confidence: 99%

Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

et al. 2020

Self Cite

View full text Add to dashboard Cite

Extensive study of typically developing individuals and those on the autism spectrum has identified a large number of brain regions associated with our ability to navigate the social world. Although it is widely appreciated that this so-called "social brain" is composed of distinct, interacting systems, these component parts have yet to be clearly elucidated. Here we used measures of eye movement and neural typicality-based on the degree to which subjects deviated from the norm-while typically developing (N = 62) and individuals with autism (N = 36) watched a large battery of movies depicting social interactions. Our findings provide clear evidence for distinct, but overlapping, neural systems underpinning two major components of the "social brain," social orienting, and inferring the mental state of others.

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Atypical co‐development of the thalamus and cortex in autism: Evidence from age‐related white–gray contrast change

Bezgin,

Lewis,

Fonov

et al. 2024

Human Brain Mapping

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Recent studies have shown that white–gray contrast (WGC) of either cortical or subcortical gray matter provides for accurate predictions of age in typically developing (TD) children, and that, at least for the cortex, it changes differently with age in subjects with autism spectrum disorder (ASD) compared to their TD peers. Our previous study showed different patterns of contrast change between ASD and TD in sensorimotor and association cortices. While that study was confined to the cortex, we hypothesized that subcortical structures, particularly the thalamus, were involved in the observed cortical dichotomy between lower and higher processing. The current paper investigates that hypothesis using the WGC measures from the thalamus in addition to those from the cortex. We compared age‐related WGC changes in the thalamus to those in the cortex. To capture the simultaneity of this change across the two structures, we devised a metric capturing the co‐development of the thalamus and cortex (CoDevTC), proportional to the magnitude of cortical and thalamic age‐related WGC change. We calculated this metric for each of the subjects in a large homogeneous sample taken from the Autism Brain Imaging Data Exchange (ABIDE) (N = 434). We used structural MRI data from the largest high‐quality cross‐sectional sample (NYU) as well as two other large high‐quality sites, GU and OHSU, all three using Siemens 3T scanners. We observed that the co‐development features in ASD and TD exhibit contrasting patterns; specifically, some higher‐order thalamic nuclei, such as the lateral dorsal nucleus, exhibited reduction in codevelopment with most of the cortex in ASD compared to TD. Moreover, this difference in the CoDevTC pattern correlates with a number of behavioral measures across multiple cognitive and physiological domains. The results support previous notions of altered connectivity in autism, but add more specific evidence about the heterogeneity in thalamocortical development that elucidates the mechanisms underlying the clinical features of ASD.

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Overt social interaction and resting state in young adult males with autism: core and contextual neural features

Cited by 42 publications

References 104 publications

Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Distinct neural mechanisms of social orienting and mentalizing revealed by independent measures of neural and eye movement typicality

Atypical co‐development of the thalamus and cortex in autism: Evidence from age‐related white–gray contrast change

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