Overview of Analytical Methods for the Determination of H2 Receptor Blockers: A Review

Abstract

Overview of various analytical methods for estimating anti-histaminic (H2 Receptor blockers) drugs, particularly for determining their concentration percentage (assay) by analytical methods developed on analytical instruments i.e., UV visible Spectrophotometer, High-Performance Liquid Chromatography, and Hyphenated techniques. The review includes a literature survey of H2 receptor blocker drugs namely cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid, Pepcid AC), and nizatidine (Axid). The examined literature survey addressed chromatographic (HPLC) and UV visible spectrophotometric methods with LC-MS/MS methods used in pure forms, pharmaceutical formulations, human plasma, and other biological fluids for their estimation. In the case of validation parameters, mostly Linearity, Recovery study, LOD, and LOQ were considered and mentioned. This review helps researchers to get detailed information regarding various analytical methods of development and validation for H2 receptor antagonists.
 Keywords: H2 Receptor blockers, HPLC, Analytical methods, ranitidine, famotidine, nizatidine.

Analytical Method: Determination of famotidine drug using chemiluminescence method

“…This technique is dependent on light intensity. This technique exhibits encouraging promise for precise and trustworthy screening of these medicinal substances [20]. Three newly created UV spectrophotometric techniques that make it easier, more affordable, sensitive, and accurate to determine the presence of famotidine in tablet and bulk drug formulations are described.…”