Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point

Bose, Tanima; Latawiec, Diane; Mondal, Partha Pratim; Mandal, Subhra

doi:10.1007/s11051-014-2527-7

Cited by 61 publications

(53 citation statements)

References 151 publications

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“…87 Several synthetic drugs are used to prepare solid lipid nanoparticles to prevent various conditions in PD. [88][89][90][91] Bromocriptine-loaded solid lipid nanoparticles have been developed and studied in patients with PD and are highly effective in reducing dyskenesia. 88 However, nanophytobioactive compounds developed using a solid lipid nanoparticle delivery system showed higher bioavailability.…”

Section: Ganesan Et Almentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

107

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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Section: Ganesan Et Almentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

107

View full text Add to dashboard Cite

show abstract

“…Other than size of NPs, surface charge and compatibility with the targeted cell type also influences their cellular uptake mechanism. 11,12 The ability to tag/label fluorescence molecules with NPs enables their real-time tracking at the cellular level using confocal fluorescence microscopy. Therefore, for the present work, we formulated Rhodamine 6G dye (Rho6G) PLGA NPs (Rho6G NPs) and/ Rilpivirine (RPV) (ARV drug) loaded PLGA NPs (RPV/Rho6G NPs), to visualize them under the confocal fluorescence microscope.…”

mentioning

confidence: 99%

Confocal fluorescence microscopy: An ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells

et al. 2015

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In the last decade, confocal fluorescence microscopy has emerged as an ultra-sensitive tool for real-time study of nanoparticles (NPs) fate at the cellular-level. According to WHO 2007 report, Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) is still one of the world's major health threats by claiming approximately 7,000 new infections daily worldwide. Although combination antiretroviral drugs (cARV) therapy has improved the life-expectancy of HIV-infected patients, routine use of high doses of cARV has serious health consequences and requires complete adherence to the regimen for success. Thus, our research goal is to fabricate long-acting novel cARV loaded poly(lactide-co-glycolic acid) (PLGA) nanoparticles (cARV-NPs) as drug delivery system. However, important aspects of cARV-NPs that require special emphasis are their cellular-uptake, potency, and sustained drug release efficiency over-time. In this article, ultra-sensitive confocal microscopy is been used to evaluate the uptake and sustained drug release kinetics of cARV-NPs in HeLa cells. To evaluate with the above goal, instead of cARV-drug, Rhodamine6G dye (fluorescent dye) loaded NPs (Rho6G NPs) have been formulated. To correlate the Rhodamin6G release kinetics with the ARV release from NPs, a parallel HPLC study was also performed. The results obtained indicate that Rho6G NPs were efficiently taken up at low concentration (<500 ng/ml)

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“…So, identifying new anticancer drugs and developing novel drug delivery systems is very important in this field . Despite several routes for delivering antitumor drug to the tumor site (Figure a), there are various barriers encountered by antitumor drug before they reach their respective targeted tumor site (Figure b) . Reticuloendothelial system (RES), by eliminating hydrophobic agents, is one of the most important biological barriers in the drug delivery to tumor tissue.…”

Section: Introductionmentioning

confidence: 99%

“…Routes of nano‐drug administration (a) and various barriers encountered (b) by nanoparticles before they reach their respective targeted tumor site. Source : Reproduced with permission from Bose et al License number: 4596930376566…”

Section: Introductionmentioning

confidence: 99%

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The role of high‐density lipoproteins in antitumor drug delivery

et al. 2019

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High‐density lipoproteins (HDLs) are the smallest lipoprotein with the highest level of protein in their surface. The main role of HDLs are reverse transport of cholesterol from peripheral tissues to the liver. More recently, HDLs have been considered as a new drug delivery system because of their small size, proper surface properties, long circulation time, biocompatibility, biodegradability, and low immune stimulation. Delivery of anticancer drug to the tumor tissue is a major obstacle against successful chemotherapy, which is because of the toxicity and poor aqueous solubility of these drugs. Loading chemotherapeutic drugs in the lipid core of HDLs can overcome the aforementioned problems and increase the efficiency of drug delivery. In this review, we discuss the use of HDLs particles in drug delivery to the tumor tissue and explain some barriers and limitations that exist in the use of HDLs as an ideal delivery vehicle.

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Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point

Cited by 61 publications

References 151 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Confocal fluorescence microscopy: An ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells

The role of high‐density lipoproteins in antitumor drug delivery

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Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point

Cited by 61 publications

References 151 publications

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Confocal fluorescence microscopy: An ultra-sensitive tool used to evaluate intracellular antiretroviral nano-drug delivery in HeLa cells

The role of high‐density lipoproteins in antitumor drug delivery

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Product

Resources

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Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models