Overview on Developed Synthesis Methods of Triazepane Heterocycles

Abstract

Triazepanes are important seven‐membered heterocyclic compounds with nitrogen at different positions in the ring, and have many pharmaceutical activities. Compounds with the triazepane core have attracted much attention as a result of their interesting biological properties. A study of the literature shows that there are various methods for the preparation of triazepanes. In this review, we have classified the methods based on the nitrogen position in the final triazepine products into four triazepine classes, namely TAP‐1,2,3, TAP‐1,2,4, TAP‐1,2,5, and TAP‐1,3,5.

Recent Advances in the Synthesis of Biscoumarin Derivatives

“…Nano‐TiO 2 @KSF was prepared from the reaction of montmorillonite KSF and titanium (IV) isopropoxide in AcOH at room temperature, and 20 mg of this catalyst was used in the synthesis of bis(4‐hydroxycoumarin) derivatives under optimized condition of the reaction, including solvent‐free, at 100 °C. Also, the efficiency of nanoTiO 2 @KSF changed only slightly (from 95% to 88%) even after three cycles (Table , entry 21)…”

Green synthesis of bis‐coumarin derivatives using Fe(SD)3as a catalyst and investigation of their biological activities

“…Cream powder, yield: 86%, m.p 243–248°C [m.p 235–236°C] . IR (KBr, ν cm −1 ): 3,448 (OH), 1,662 (stretch, C=O), 1,613 (C=C, olefin), 1,567 (C=C‐stretch, Ar), 1,349 (C–O–C lacton), 1,097 (C–O ether), and 763 (OOP, C–H).…”

“…Other procedures that used microwaves and ultrasound irradiation have been carried out using catalysts such as molecular I 2 , [bmim][BF4], (Bu) 4 NBr (TBAB), sodium dodecyl sulfate (NaOSO 2 OC 12 H 25 ) (SDS), P 4 VPy–CuO‐NPs, RuCl 3 . n H 2 O, sulfated titania [TiO 2 /SO 4 2− ], Melamine trisulfonic acid (MTSA), tetrabutylammonium hexatungstate [TBA] 2 [W 6 O 19 ], Ni‐NPs, POCl 3 in dry dimethylformamide (DMF), TiO 2 @KSF, ZnO nanocomposite, diethyl aluminum chloride (Et 2 AlCl), LiClO 4 , Piperidine, nano‐Fe 3 O 4 , kit‐6‐mesoporous silica‐coated magnetic nanoparticles, amino glucose‐functionalized silica‐coated NiFe 2 O 4 nanoparticles, Fe 3 O 4 @SiO 2 @KIT‐6, [BDBDMIm]Br‐CAN, citric acid, and SBPDSA . More catalysts and different conditions for the synthesis of biscoumarins are gathered in our recent review …”

Synthesis of Benzotriazepin-1-ones via Decarboxylative [4 + 3]-Annulation of Isatoic Anhydrides with Nitrile Imines

“…To date, there are limited and underexplored methods for the convenient synthesis of benzotriazepinones . Among the strategies for synthesizing nitrogen-rich seven-membered heterocycles, [4 + 3]-cycloaddition stands out as the most streamlined, straightforward, and cost-effective solution, thanks to the readily accessible precursors .…”