Oxalate degradation by intestinal lactic acid bacteria in dogs and cats

Weese, J Scott

doi:10.1016/s0378-1135(04)00105-1

Cited by 5 publications

(9 citation statements)

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“…All the species or strains in a particular genera do not metabolize oxalate (Weese et al . ; Murphy et al . ).…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies have reported varying degrees of oxalate degradation in different faecal culture conditions that favour the growth of O. formigenes and lactic acid bacteria (Weese et al . ; Murphy et al . ; Ren et al .…”

Section: Discussionmentioning

confidence: 99%

“…Prior studies in this context were focused on a few specific bacteria, including Oxalobacter formigenes , Bifidobacterium spp and Lactobacillus spp, that are known to efficiently metabolize oxalate in dogs (Weese et al . ; Murphy et al . ; Weese and Palmer ; Ren et al .…”

Section: Introductionmentioning

confidence: 99%

“…Microbes with diverse metabolic capabilities colonize the intestine of dogs and many of them express oxalate‐metabolizing enzymes (Weese et al . ; Murphy et al . ; Ren et al .…”

Section: Introductionmentioning

confidence: 99%

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Comparative faecal microbiota of dogs with and without calcium oxalate stones

et al. 2012

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Aims The absence of enteric oxalate‐metabolizing bacterial species (OMBS) increases the likelihood of calcium oxalate (CaOx) urolithiasis in humans and dogs. The goal of this study was to compare the gut microbiota of healthy dogs and CaOx stone formed dogs (CaOx‐dogs), especially with respect to OMBS. Methods and Results Faecal samples from healthy and CaOx‐dogs were obtained to analyse the hindgut microbiota by sequencing the V3 region of bacterial 16S rDNA. In total, 1223 operational taxonomic units (OTUs) were identified at 97% identity. Only 38% of these OTUs were shared by both groups. Significant differences in the relative abundance of 152 OTUs and 36 genera were observed between the two groups of dogs. Conclusions The faecal microbiota of healthy dogs is distinct from that of CaOx‐dogs, indicating that the microbiota is altered in CaOx‐dogs. Significance and Impact of the Study This is the first study that has compared the gut microbial diversity in healthy and CaOx‐dogs. Results of this study indicate the future need for functional and comparative analyses of the total array of oxalate‐metabolizing genes between healthy and CaOx stone formers, rather than focusing on specific bacterial species, to understand the critical role of OMBS in CaOx urolithiasis.

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“…All the species or strains in a particular genera do not metabolize oxalate (Weese et al . ; Murphy et al . ).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Microbes with diverse metabolic capabilities colonize the intestine of dogs and many of them express oxalate‐metabolizing enzymes (Weese et al . ; Murphy et al . ; Ren et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative faecal microbiota of dogs with and without calcium oxalate stones

et al. 2012

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“…Little attention has been placed on the dietary consumption of prebiotics, diet-derived constituents that feed and promote the growth of oxalate-degrading bacteria. A study in dogs and cats examined the effect of different food-derived prebiotics (fructooligosaccharides, guar gum, inulin, lactitol, gum Arabic, and maltodextrin) on gastrointestinal bacterial profile [80]. Results indicated that manipulation of the diet for these prebiotics could enhance oxalate degradation, resulting in reduced oxalate excreted in urine.…”

Section: Oxalate Absorption: a Better Clinical Target Than Intake?mentioning

confidence: 99%