Oxidant Status in Maternal and Cord Plasma and Placental Tissue in Gestational Diabetes

Bırı, Aydan; Onan, A.; Devrım, Erdinç; Babacan, Figen; Kavutçu, Mustafa; Durak, İlker

doi:10.1016/j.placenta.2005.01.002

Cited by 144 publications

(121 citation statements)

References 28 publications

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“…26 Maternal hyperglycemia is also associated with an increased production of free radicals and oxidative stress. 27 In our study, maternal obesity and diabetes were associated with elevated risk of ID similar to that of ASD, whereas they were not clearly associated with risks of other DD and ADHD. The similarity between ASD and ID was mainly driven by cases with co-occurring ASD and ID.…”

Section: Figurecontrasting

confidence: 43%

The Association of Maternal Obesity and Diabetes With Autism and Other Developmental Disabilities

Li¹,

Fallin²,

Riley³

et al. 2016

Pediatrics

247

200

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Section: Figurecontrasting

confidence: 43%

The Association of Maternal Obesity and Diabetes With Autism and Other Developmental Disabilities

Li¹,

Fallin²,

Riley³

et al. 2016

Pediatrics

247

200

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“…Several placenta-related disorders such as pre-eclampsia (PE), intrauterine growth restriction (IUGR), miscarriage, and gestational diabetes mellitus are characterized by increased placental oxidative stress (Coughlan et al 2004, Biri et al 2006, Jauniaux et al 2006, Myatt 2010). In the case of PE, shallow implantation leads to intermittent placental blood flow through retention of vascular reactivity (Burton & Jauniaux 2011).…”

Section: Introductionmentioning

confidence: 99%

Maternal omega-3 fatty acid intake increases placental labyrinthine antioxidant capacity but does not protect against fetal growth restriction induced by placental ischaemia–reperfusion injury

Jones¹,

Mark²,

Waddell³

2013

Reproduction

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Placental oxidative stress plays a key role in the pathophysiology of several placenta-related disorders. Oxidative stress occurs when excess reactive oxygen species (ROS) damages cellular components, an outcome limited by antioxidant enzymes; mitochondrial uncoupling protein 2 (UCP2) also limits ROS production. We recently reported that maternal dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation reduced placental oxidative damage and enhanced fetal and placental growth in the rats. Here, we examined the effect of n-3 PUFAs on placental antioxidant defences and whether n-3 PUFA supplementation could prevent growth restriction induced by placental ischaemia-reperfusion (IR), a known inducer of oxidative stress. Rats were fed either standard or high-n-3 PUFA diets from day 1 of pregnancy. Placentas were collected on days 17 and 22 in untreated pregnancies (termZday 23) and at day 22 following IR treatment on day 17. Expression of several antioxidant enzyme genes (Sod1, Sod2, Sod3, Cat, Txn1 and Gpx3) and Ucp2 was measured by quantitative RT-PCR in the placental labyrinth zone (LZ) and junctional zone (JZ). Cytosolic superoxide dismutase (SOD), mitochondrial SOD and catalase (CAT) activities were also analyzed. Maternal n-3 PUFA supplementation increased LZ mRNA expression of Cat at both gestational days (2-and 1.5-fold respectively; P!0.01) and female Sod2 at day 22 (1.4-fold, P!0.01). Cytosolic SOD activity increased with n-3 PUFA supplementation at day 22 (1.3-fold, P!0.05). Sod1 and Txn1 expression decreased marginally (30 and 22%, P!0.05). JZ antioxidant defences were largely unaffected by diet. Despite increased LZ antioxidant defences, maternal n-3 PUFA supplementation did not protect against placental IR-induced growth restriction of the fetus and placental LZ.

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“…The increase in TOS levels also indicated an imbalance between oxidant/antioxidant parameters. Increased MDA generation has previously been shown in the maternal and cord plasma [36,37]. In experimental studies, aberrant ROS generation in type 1 and 2 diabetes mellitus have been observed [38,39].…”

Section: Discussionmentioning

confidence: 84%

The Relation Of Oxidative Stress Biomarkers With Proinflammatory Cytokines In Gestational Diabetes

Genç¹,

Kusku-Kiraz²,

Dervisoglu³

et al. 2017

Clinical-Investigation

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Background: It has been shown that the synthesis and secretion of cytokines is influenced by the imbalance in oxidant/antioxidant status. In this study, the relation between the circulating levels of oxidative stress biomarkers and proinflammatory cytokines was searched in gestational diabetes mellitus (GDM) patients in order to evaluate the possible role of oxidative stress in ongoing proinflammatory condition and impaired glucose homeostasis.

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Oxidant Status in Maternal and Cord Plasma and Placental Tissue in Gestational Diabetes

Cited by 144 publications

References 28 publications

The Association of Maternal Obesity and Diabetes With Autism and Other Developmental Disabilities

The Association of Maternal Obesity and Diabetes With Autism and Other Developmental Disabilities

Maternal omega-3 fatty acid intake increases placental labyrinthine antioxidant capacity but does not protect against fetal growth restriction induced by placental ischaemia–reperfusion injury

The Relation Of Oxidative Stress Biomarkers With Proinflammatory Cytokines In Gestational Diabetes

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