Oxidant stress and essential fatty acids in patients with risk and established ARDS

Effects of Inhaled Nitric Oxide on Oxidative Stress and Histopathological and Inflammatory Lung Injury in a Saline-Lavaged Rabbit Model of Acute Lung Injury

“…These lymphokines augment free radical generation by PMN leukocytes, macrophages, and other cells, which may ultimately produce ARDS. 34 Rotta et al, 17 in a similar ALI rabbit model, studied oxidative stress by measuring malondialdehyde, a nonspecific biomarker of lipid peroxidation. 35 This assay has been criticized due to its low specificity and sensitivity.…”

The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease

“…Although such studies can only provide indirect evidence for a detrimental consequence of increase linoleic acid metabolism, there have been clear demonstrations of the toxicity of derivatives of linoleic acid. The most impressive link was made by studying patients with acute respiratory distress syndrome who generated high levels of 9,10-DiHOME (Quinlan et al, 1996;Moghaddam et al, 1997;Kumar et al, 2000). Given that 9,10-DiHOME production is catalyzed by the sEH, it is not surprising that sEH inhibitors were able to provide protection in such a situation.…”

The Activity of Oxidative Stress Markers in Acute Respiratory Distress Syndrome / Oksidativa Stresa Marķieru Aktivitate Akuta Respiratora Distresa Sindroma Gadījuma

“…The reactive oxygen molecules can be produced by all cells in the organism due to enzymatic and non-enzymatic processes. Lists of oxidative stress markers associated with development of many disorders are already known (Kumar et al, 2000;Bowler et al, 2003;Crimi et al, 2006), but their predictive role in ARDS is still underestimated. Reactive oxygen species initiate cellular tissue death by lipid peroxidation, and as a result also modulation of proteins and DNA.…”