Oxidation Reduction is a Key Process for Successful Treatment of Psoriasis by Narrow-band UVB Phototherapy

Gu, Xiaolian; Nylander, Elisabet; Coates, Philip J.; Nylander, Karin

doi:10.2340/00015555-1905

Cited by 18 publications

(19 citation statements)

References 31 publications

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“…UVB radiation is a well-established and highly efficacious treatment for the management of psoriasis (21)(22)(23)(24)(25). Increased T-cell apoptosis, induction of vitamin D and reduced epidermal and endothelial proliferation are known key factors in the anti-inflammatory effect of UVB radiation (26,27,(44)(45)(46)(47)(48). In the present study, NB-UVB treatment regimen was moderately effective for our patients, with 47% reaching PASI75.…”

Section: Discussionmentioning

confidence: 51%

Psoriasis and Pro-angiogenetic Factor CD93: Gene Expression and Association with Gene Polymorphism Suggests a Role in Disease Pathogenesis

Duvetorp¹,

Olsen²,

Skarstedt³

et al. 2017

Acta Derm Venerol

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CD93 is involved in angiogenesis and inflammation, both of which are key processes in the pathogenesis of psoriasis. CD93 was studied in serum, peripheral blood mononuclear cells and skin of patients with psoriasis and controls. Furthermore, allele frequencies for CD93 single-nucleotide polymorphisms rs2749812 and rs2749817 were assessed in patients with psoriasis compared with controls and the effect of narrowband ultraviolet B (NB-UVB) treatment on CD93 gene expression was evaluated in the skin of patients with psoriasis. CD93 gene expression was significantly increased in lesional and non-lesional skin from patients with psoriasis compared with controls. Immunohistochemistry revealed CD93 staining in dermal endothelial cells in lesional skin, and psoriasis was significantly associated with rs2749817 CD93 gene polymorphism. NB-UVB treatment of patients with psoriasis did not alter skin CD93 gene expression. Increased protein expression of CD93 psoriatic skin and association with the rs2749817 polymorphism suggests that CD93 plays a role in psoriasis disease pathogenesis.

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Section: Discussionmentioning

confidence: 51%

Psoriasis and Pro-angiogenetic Factor CD93: Gene Expression and Association with Gene Polymorphism Suggests a Role in Disease Pathogenesis

Duvetorp¹,

Olsen²,

Skarstedt³

et al. 2017

Acta Derm Venerol

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“…The cycling conditions were set as follows: enzyme activation at 95 °C for 3 min, 40 cycles of denaturation at 95 °C for 15 sec and annealing/extension at 60 °C for 60 sec. For OAS2 mRNA levels in psoriasis, we used our previous published gene expression array data of the same material25.…”

Section: Methodsmentioning

confidence: 99%

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

Boldrup

Coates

et al. 2016

Sci Rep

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Epigenetic modifications are essential regulators of biological processes. Decreased DNA methylation of OAS2 (2′-5′-Oligoadenylate Synthetase 2), encoding an antiviral protein, has been seen in psoriasis. To provide further insight into the epigenetic regulation of OAS2, we performed pyrosequencing to detect OAS2 DNA methylation status at 11 promoter and first exon located CpG sites in psoriasis (n = 12) and two common subtypes of squamous cell carcinoma (SCC) of the head and neck: tongue (n = 12) and tonsillar (n = 11). Compared to corresponding controls, a general hypomethylation was seen in psoriasis. In tongue and tonsillar SCC, hypomethylation was found at only two CpG sites, the same two sites that were least demethylated in psoriasis. Despite differences in the specific residues targeted for methylation/demethylation, OAS2 expression was upregulated in all conditions and correlations between methylation and expression were seen in psoriasis and tongue SCC. Distinctive methylation status at four successively located CpG sites within a genomic area of 63 bp reveals a delicately integrated epigenetic program and indicates that detailed analysis of individual CpGs provides additional information into the mechanisms of epigenetic regulation in specific disease states. Methylation analyses as clinical biomarkers need to be tailored according to disease-specific sites.

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“…Çünkü metotreksat, dar bant UVB fototerapi, antitümör nekrozis faktör-α PAŞİ skorlarında düzelme, oksidasyon ve lipit peroksidasyon ürünlerinde azalma ile birliktedir (39)(40)(41) . Oksidatif stresin daha yüksek saptandığı uzun hastalık süresi ve PAŞİ skorlarının karşılaştırılması ile bu kısıtlılığı azaltmaya çalıştık.…”

Section: Discussionunclassified

Clinical Value of Antioxidant Enzymes and Oxidative Biomarkers in Psoriasis

Ataş¹,

Hacınecipoğlu²,

Gönül³

et al. 2017

Okmeydani Medical Journal

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Oxidation Reduction is a Key Process for Successful Treatment of Psoriasis by Narrow-band UVB Phototherapy

Cited by 18 publications

References 31 publications

Psoriasis and Pro-angiogenetic Factor CD93: Gene Expression and Association with Gene Polymorphism Suggests a Role in Disease Pathogenesis

Psoriasis and Pro-angiogenetic Factor CD93: Gene Expression and Association with Gene Polymorphism Suggests a Role in Disease Pathogenesis

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

Clinical Value of Antioxidant Enzymes and Oxidative Biomarkers in Psoriasis

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