Oxidation states in metallocenes: A key mechanistic component in cancer alleviation

Das, Rudradip; Chatterjee, Deep Rohan; Shard, Amit

doi:10.1016/j.ccr.2024.215666

Cited by 4 publications

(1 citation statement)

References 181 publications

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“…The antitumor activity of the metallocenes of MCp 2 X 2 probably depends on the hydrolysis of the metal, which for Ti, V, Zr, and Mo proceeds much faster than for cisplatin. Some studies have suggested a correlation between DNA binding and anticancer activity in that immediate complexation of the DNA nucleotides occurred with the active Ti and Mo metallocenes, whereas the biologically inactive Hf and Zr metallocenes did not bind significantly to DNA [ 64 ].…”

Section: D-elements Of Groupmentioning

confidence: 99%

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7

Kostova

2024

Molecules

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With the progression in the field of bioinorganic chemistry, the role of transition metal complexes as the most widely used therapeutics is becoming a more and more attractive research area. The complexes of transition metals possess a great variety of attractive pharmacological properties, including anticancer, anti-inflammatory, antioxidant, anti-infective, etc., activities. Transition metal complexes have proven to be potential alternatives to biologically active organic compounds, especially as antitumor agents. The performance of metal coordination compounds in living systems is anticipated to differ generally from the action of non-metal-containing drugs and may offer unique diagnostic and/or therapeutic opportunities. In this review, the rapid development and application of metallocenes and metal complexes of elements from Groups 4 to 7 in cancer diagnostics and therapy have been summarized. Most of the heavy metals discussed in the current review are newly discovered metals. That is why the use of their metal-based compounds has attracted a lot of attention concerning their organometallic and coordination chemistry. All of this imposes more systematic studies on their biological activity, biocompatibility, and toxicity and presupposes further investigations.

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Section: D-elements Of Groupmentioning

confidence: 99%

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7

Kostova

2024

Molecules

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Red Fluorescent Aminoferrocene (Pro)Drugs for in Cellulo and in Vivo Imaging

Chernii,

Selin,

Bila

et al. 2024

Chemistry A European J

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Red fluorescent dyes are usually charged, lypophilic molecules with the relatively high molecular weight, which tend to localize in specific intracellular locations, e.g., a cyanine dye Cy5 is biased towards mitochondria. They are often used as markers of biomolecules including nucleic acids and proteins. Since molecular weight of the dyes is much smaller than that of the biomolecules, the labelling has a negligible effect on the properties of the biomolecules. In contrast, conjugation of the dyes to low molecular weight (pro)drugs can dramatically alter their properties. For example, conjugates of Cy5 with lysosome‐targeting aminoferrocenes accumulate in mitochondria and exhibit no intracellular effects characteristic for the parent (pro)drugs. Herein we tested several neutral and negatively charged dyes for labelling lysosome‐targeting aminoferrocenes 7 and 8 as well as a non‐targeted control 3. We found that a BODIPY derivative BDP‐TR exhibits the desired unbiased properties: the conjugation does not disturb the intracellular localization of the (pro)drugs, their mode of action and cancer cell specificity. We used the conjugates to clarify the mechanism of action of the aminoferrocenes. In particular, we identified new intermediates, explained why lysosome targeting aminoferrocenes are more potent than their non‐targeted counterparts and evaluated their distribution in vivo.

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Two New Inner-sphere Pt(II) Thiosemicarbazone Schiff Base Complexes Immobilized into Magnetic Nanoparticles: Synthesis, Characterization, and Biological Investigations

Abo El-Ata,

El-Gamil,

Abou El-Reash

et al. 2024

Inorganic Chemistry Communications

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Oxidation states in metallocenes: A key mechanistic component in cancer alleviation

Cited by 4 publications

References 181 publications

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7

Red Fluorescent Aminoferrocene (Pro)Drugs for in Cellulo and in Vivo Imaging

Two New Inner-sphere Pt(II) Thiosemicarbazone Schiff Base Complexes Immobilized into Magnetic Nanoparticles: Synthesis, Characterization, and Biological Investigations

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