Oxidation-Triggerable Liposome Incorporating Poly(Hydroxyethyl Acrylate-co-Allyl methyl sulfide) as an Anticancer Carrier of Doxorubicin

Abstract

Since cancer cells are oxidative in nature, anti-cancer agents can be delivered to cancer cells specifically without causing severe normal cell toxicity if the drug carriers are designed to be sensitive to the intrinsic characteristic. Oxidation-sensitive liposomes were developed by stabilizing dioleoylphosphatidyl ethanolamine (DOPE) bilayers with folate-conjugated poly(hydroxyethyl acrylate-co-allyl methyl sulfide) (F-P(HEA-AMS)). The copolymer, synthesized by a free radical polymerization, was surface-active but lost its surface activity after AMS unit was oxidized by H2O2 treatment. The liposomes with F-P(HEA-AMS) were sensitive to H2O2 concentration (0%, 0.5%, 1.0%, and 2.0%) in terms of release, possibly because the copolymer lost its surface activity and its bilayer-stabilizing ability upon oxidation. Fluorescence-activated cell sorting (FACS) and confocal laser scanning microscopy (CLSM) revealed that doxorubicin (DOX)-loaded liposomes stabilized with folate-conjugated copolymers markedly promoted the transport of the anti-cancer drug to cancer cells. This was possible because the liposomes were readily translocated into the cancer cells via receptor-mediated endocytosis. This liposome would be applicable to the delivery carrier of anticancer drugs.

ThermOxshield ion pair self assembly unleashing suppressed release

“…Therefore amphiphiles can selfassemble to form nanostructures which play a major role in drug delivery systems. [16][17][18][19][20] Hydrophilic drugs and/or lipophilic drugs can be loaded in the self-assembled structure due to their versatility and they can perforate the tissue due to their nano size and deliver in the target imbuing drug carriers with the aid of various stimuli. [21][22][23][24][25] Ion pair self-assembly can react to multiple environmental changes among numerous stimuli-responsive systems for two primary reasons.…”

In Vivo and In Vitro Anticancer Activity of Doxorubicin-loaded DNA-AuNP Nanocarrier for the Ovarian Cancer Treatment

“…Conventional chemotherapy has limitations with a lack of solubility in an aqueous solution, side effects at high-doses, and a short bloodstream circulation half-life [4][5][6]. To overcome these limitations, many approaches using nanoparticles for the drug delivery carrier, such as liposomes [7][8][9], dendrimers [10,11], silicon nanoparticles (SiNPs) [12,13], and gold nanoparticles (AuNPs) [14][15][16][17] have been proposed. Among those nanoparticles, the AuNPs have some advantages as the drug delivery carrier, such as that it is easy to synthesize with controlled size and shape, simple surface chemistry, and high biocompatibility [18,19].…”

Cancer Nanomedicine

“…Within this Special Issue, a diverse range of cancer nanomedicines have been discussed, including the more traditional organic-based systems, such as lipid [ 1 , 2 , 3 , 4 , 5 , 6 ], polymer [ 7 , 8 , 9 , 10 , 11 ] and cyclodextrin-based [ 12 ] particulates. Additionally, there are multiple studies from the growing area of inorganic systems, such as carbon nanomaterials (such as graphene oxide [ 13 , 14 ] and carbon nanotubes [ 15 ]) as well as other more established metallic nanomaterials, such as gold [ 16 , 17 ], iron oxide [ 18 , 19 ] and silica-based [ 20 , 21 ] systems.…”

“…As the science develops and leads us down new avenues, the findings and their meaning are closely scrutinised and debated within the community. This issue includes 32 scientific manuscripts, 13 review articles and 1 case report reflecting the hot topics within this area [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”