Oxidative and antioxidant changes during formation of unstable atherosclerotic plaque

Ragino, Yu. I.; Chernyavski, A. M.; Polonskaya, Yа. V.; Волков, А. М.; Semaeva, Elvira; Воевода, М. И.

doi:10.1007/s10517-007-0398-y

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Although there are no studies on the relationship between retinol levels with FI, low plasma retinol was found in individuals with atherosclerosis. In addition, the unstable atherosclerotic plaque is also characterized by low retinol content [7, 15, 43]. Our results corroborate these findings; however, we do not find statistically significant difference in the mean serum retinol levels among FI groups.…”

Section: Discussionsupporting

confidence: 87%

“…Retinol is one of the circulating forms of plasma vitamin A. Low retinol levels are reportedly a characteristic of unstable atherosclerotic plaques [15]. Patients with CAD or atherosclerosis may have significantly lower circulating levels of retinol [16].…”

Section: Introductionmentioning

confidence: 99%

“…Patients with CAD or atherosclerosis may have significantly lower circulating levels of retinol [16]. Reduced retinol has been suggested to be a risk factor for CVD and mortality [7, 15, 17].…”

Section: Introductionmentioning

confidence: 99%

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Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease

Miranda

Duarte

Cruz

et al. 2018

Journal of Nutrition and Metabolism

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Background and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression of atherosclerosis. This study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with the extent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n=177) aged 30–74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using the Friesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n=90), FI = 5–9 (n=50), and FI = 10–15 (n=37). Serum levels of vitamins were ‬determined via high-performance liquid chromatography and serum biochemical analysis. Results. Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals in this group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p < 0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p=0.03). No difference was observed between the mean serum retinol levels among the FI-based groups (n=0.492), and the low frequency of retinol was consistent among the FI groups (n=0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia is probably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensive coronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease

Miranda

Duarte

Cruz

et al. 2018

Journal of Nutrition and Metabolism

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Plasma retinol: A novel marker for cardiovascular disease mortality in Australian adults

Brazionis

Itsiopoulos

O’Dea

2012

Nutrition, Metabolism and Cardiovascular Diseases

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Insulin resistance associated with metabolic syndrome as an indicator of cardiovascular risk

Донцов

Васильева

2016

Klin. med.

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Aim. To study blood insulin level in patients with coronary heart disease (CHD) with and without metabolic syndrome (MS) and its relation to cardiovascular risk factors. Materials and methods. We examined 127 patients with stable coronary heart disease (mean age 59.4±5.7 yr) including 63 with MS and 64 without it. The control group consisted of 80 practically healthy subjects. Bloods insulin was determined by immunochemoluminescence, glycated hemoglobin (HbA) by immunoturbidimetry, total cholesterol, HDLP cholesterol, and triglycerides by enzymatic colorimetric method, oxidized LDLP, IL-1β, IL-6, and tumour necrosis factor-a by enzyme immunoassay. The degree of depression was estimated using the Zung scale. Results. Blood insulin level in healthy subjects, CHD patients with and without MS was 6.3 (6.20;6.62), 15.5 (13.96, 16.3) and 9.5 (9.2, 10.1) mcIE/ml respectively (p<0.001). HOMA-IR directly correlated with MBI, waist circumference, HbA total cholesterol, triglyceride, oxidized LDLP, IL-1β, IL-6, and tumour necrosis factor-a levels and negatively with the HDLP cholesterol level. Conclusion. In patients with CHD, metabolic syndrome is associated with a set of additional cardiovascular risk factors, viz. hyperinsulinemia, insulin resistance, increased HbA level, dyslipidemia, oxidative modification of LDLP, activation of proinflammatory cytokines, and depressive disorders. Close correlation of HOMA-IR with certain pathogenetic factors of CHD allow to use it as an indicator of cardiovascular risk in patients with CHD and MS.

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Oxidative and antioxidant changes during formation of unstable atherosclerotic plaque

Cited by 3 publications

References 10 publications

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease

Association of Serum Alpha-Tocopherol and Retinol with the Extent of Coronary Lesions in Coronary Artery Disease

Plasma retinol: A novel marker for cardiovascular disease mortality in Australian adults

Insulin resistance associated with metabolic syndrome as an indicator of cardiovascular risk

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