Oxidative Cell Injury as a Predictor of Endometriosis Progression

Carvalho, L.; Abrão, Maurício Simões; Biscotti, Charles V.; Sharma, Rakesh K.; Nutter, Benjamin; Falcone, Tommaso

doi:10.1177/1933719112466301

Cited by 35 publications

(22 citation statements)

References 45 publications

(83 reference statements)

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“…LOH at MLH1 and MSH2 in adenomyosis also has been reported . Transcriptional inactivation of the MLH1 gene through promoter hypermethylation is often associated with MSI, which is reported to be associated with the malignant transformation of endometriosis …”

Section: Changing Pressure For Genomic Alteration Due To Oxidative Stmentioning

confidence: 94%

“…Higher DNA repair capability in women with endometriosis has been reported. 381 Higher DNA damage and lower DNA repair activity have been reported to be related to endometriosis progression, ie, rASRM stage, 382 although the use of rASRM stage as a measurement for disease progression is debatable.…”

Section: Mismatch Repair Genes In Endometriosismentioning

confidence: 99%

“…385 Transcriptional inactivation of the MLH1 gene through promoter hypermethylation is often associated with MSI, 383 which is reported to be associated with the malignant transformation of endometriosis. [382][383][384][385][386] Promoter hypermethylation of MLH1 has been found in ~4%…”

Section: Mismatch Repair Genes In Endometriosismentioning

confidence: 99%

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Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Guo

2018

Reprod Medicine & Biology

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BackgroundOne recent study reports cancer driver mutations in deep endometriosis, but its biological/clinical significance remains unclear. Since the natural history of endometriosis is essentially gradual progression toward fibrosis, it is thus hypothesized that the six driver genes reported to be mutated in endometriosis (the RP set) may play important roles in fibrogenesis but not necessarily malignant transformation.MethodsExtensive PubMed search to see whether RP and another set of driver genes not yet reported (NR) to be mutated in endometriosis have any roles in fibrogenesis. All studies reporting on the role of fibrogenesis of the genes in both RP and NR sets were retrieved and evaluated in this review.ResultsAll six RP genes were involved in various aspects of fibrogenesis as compared with only three NR genes. These nine genes can be anchored in networks linking with their upstream and downstream genes that are known to be aberrantly expressed in endometriosis, piecing together seemingly unrelated findings.ConclusionsGiven that somatic driver mutations can and do occur frequently in physiologically normal tissues, it is argued that these mutations in endometriosis are not necessarily synonymous with malignancy or premalignancy, but the result of enormous pressure for fibrogenesis.

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Section: Changing Pressure For Genomic Alteration Due To Oxidative Stmentioning

confidence: 94%

Section: Mismatch Repair Genes In Endometriosismentioning

confidence: 99%

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Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Guo

2018

Reprod Medicine & Biology

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“…The accumulating data thus correlate oxidative stress in the peritoneal cavity and the pathogenesis of endometriosis (Polak and Kotarski 2010) and conclude that oxidative stress as a biomarker of cell injury seems to be a reliable quantitative test of endometriosis severity (Carvalho et al 2013).…”

Section: Ros and Fertility-related Diseases Endometriosismentioning

confidence: 99%

“…In several independent studies regarding this pathology and oxidative stress biomarkers, peritoneal fluid from women suffering from endometriosis was found to have increased levels of MDA, 8-OHdG, 8-oxoguanine DNA glycosylase, protein carbonyls, interleukin-6, TNFα, interleukin-1β, interleukin-8, VEGF, and 8-iso-prostangladin F2-alpha (8-iso-PGF2α) (Andrade et al2010;Carvalho et al 2013;Matsuzaki and Schubert2010;Mier-Cabrera et al 2011;Montuschi et al 2004;Morrow et al 1992;Rong et al 2002;Sharma et al2010). Furthermore, 8-iso-PGF2α levels were concluded to be useful in predicting oxidative status in diseases such as endometriosis (Montuschi et al 2004;Morrow et al 1992;Sharma et al 2010).…”

Section: Ros and Fertility-related Diseases Endometriosismentioning

confidence: 99%

Oxidative stress in pregnancy and fertility pathologies

Pereira

Martel

2014

Cell Biol Toxicol

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Oxidative stress designates the state of imbalance between reactive oxygen species (ROS) production and antioxidant levels. In a healthy placenta, there is an increase in ROS production, due to formation of new tissues and inherent metabolism, but this is balanced by higher levels of antioxidants. However, this balance is lost in some situations, with a consequent increase in oxidative stress levels. Oxidative stress has been implicated in several placental disorders and pregnancy pathologies. The present review intends to summarize what is known about the relationship between oxidative stress and well-known pregnancy disorders.

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Endometrial biomarkers for the non-invasive diagnosis of endometriosis

Gupta

Hull

Fraser

et al. 2016

Cochrane Database of Systematic Reviews

100

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We could not statistically evaluate most of the biomarkers assessed in this review in a meaningful way. In view of the low quality of most of the included studies, the findings of this review should be interpreted with caution. Although PGP 9.5 met the criteria for a replacement test, it demonstrated considerable inter study heterogeneity in diagnostic estimates, the source of which could not be determined. Several endometrial biomarkers, such as endometrial proteome, 17βHSD2, IL-1R2, caldesmon and other neural markers (VIP, CGRP, SP, NPY and combination of VIP, PGP 9.5 and SP) showed promising evidence of diagnostic accuracy, but there was insufficient or poor quality evidence for any clinical recommendations. Laparoscopy remains the gold standard for the diagnosis of endometriosis, and using any non-invasive tests should only be undertaken in a research setting. We have also identified a number of biomarkers that demonstrated no diagnostic value for endometriosis. We recommend that researchers direct future studies towards biomarkers with high diagnostic potential in good quality diagnostic studies.

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Oxidative Cell Injury as a Predictor of Endometriosis Progression

Abstract: In this cohort, higher DNA damage and lower DNA repair activity was related to endometriosis progression. Our results indicate that oxidative stress as a biomarker of cell injury can be used as a reliable quantitative test of endometriosis severity.

Cited by 35 publications

References 45 publications

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Oxidative stress in pregnancy and fertility pathologies

Endometrial biomarkers for the non-invasive diagnosis of endometriosis

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