Oxidative damage and alterations in antioxidant enzyme activities in the kidneys of rat exposed to trichloroacetic acid: protective role of date palm fruit

Arem, Amira El; Zekri, Mouna; Thouri, Amira; Saafi, Emna Behija; Ghrairi, Fatma; Ayed, Ahmad; Zakhama, Abdelfattah; Achour, Lotfi

doi:10.1007/s13105-013-0302-3

Cited by 10 publications

(11 citation statements)

References 52 publications

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“…GSH is a tripeptide low molecular weight protein that plays a fundamental role in detoxifying drugs and toxins, metabolism and regulation of various pathways to maintain homeostasis. We found that exposure to TCE led to decreased GSH in a dose-dependent manner that is in agreement with other studies ( 12 , 24 , 29 , 30 ). Our data showed that vitamin E enhanced GSH level in TCE treated rats and protected kidney against TCE-induced oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, the TCE-treated rats showed a significant increase in the MDA level in a dose-dependent manner. In agreement with this finding, TCE has been shown to increase the level of MDA ( 24 , 25 , 29 , 30 ) Our data showed vitamin E attenuated MDA level . Our finding suggested that vitamin E has potential to protect kidney against TCE induced lipid peroxidation.…”

Section: Discussionsupporting

confidence: 91%

“…Renal proximal tubule is the main site for the biotransformation of xenobiotics and cells of proximal tubule contain higher concentrations of enzymes involved in GSH conjugation. Previous studies have shown that TCE metabolites dichlorovinyl glutathione (DCVG) and dichlorovinil cysteine (DCVC) are toxic to kidney ( 25 - 30 ).…”

Section: Discussionmentioning

confidence: 99%

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Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats

Heydari¹,

Ahmadizadeh²,

Angali³

2016

J Nephropathol

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Background: 1,1,2-Trichloroethylene (TCE) is an important organic solvent which is widespread in the environment. Work place exposure to TCE has been associated adverse effects in many organs including kidney. Vitamin E is an antioxidant that can overcome oxidative stress. Objectives: The aim of the present study is to examine the role of vitamin E against destructive effects of TCE on rat kidney. Materials and Methods: A total of 35 male Wistar rats were randomly divided into seven groups of equal number in each. The rats in group I were the controls received vehicle only. Animals in groups III, V and VII received intraperitoneal injection (i.p) of corn oil. Rats in groups of II, IV, and VI were received vitamin E at a dose of 200 mg/kg; 30 minutes later, animals were received TCE (i.p) at doses of 1000 mg/kg (groups II and III), 1500 mg/kg (groups of IV and V), and 2000 mg/kg (groups of VI and VII) respectively. The experiment repeated for 7 consecutive days. Twenty-four hours after last administration, animals were killed with overdose of sodium pentobarbital. Blood samples were analyzed for blood urea nitrogen (BUN) and creatinine (Cr). One part of the kidney tissues were excised for measuring malondialdehyde (MDA) and glutathione (GSH) concentrations. Another part were excised for histopathological estimation. Results: TCE induced a dose-dependent elevation in BUN, Cr, MDA and markedly decreased GSH level when compared to those in control rats. TCE-induced dose-dependent injury in rat kidney tissue. Vitamin E significantly decreased BUN, Cr, MDA and increased GSH levels and protected kidney damage in TCE treated animals. Conclusions: The observations suggest that vitamin E may have a protective effect against TCE-induced oxidative stress in the rat kidney.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

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Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats

Heydari¹,

Ahmadizadeh²,

Angali³

2016

J Nephropathol

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“…A number of in vitro and in vivo studies have been performed to substantiate their use in folk medicine [1,2]. Date extracts were shown to possess a myriad of pharmacological properties such as antioxidant [3], anti-inflammatory [4], antiatherogenic [5], hepatoprotective [6], anticancer [6], nephroprotective [7], antimicrobial [8], antiallergic [9], immunostimulatory [10], neuroprotective [11], antifungal [12], antimutagenic [13] and gastrointestinal transition stimulatory activity [14]. Date supplementation was shown to be beneficial in Alzheimer's disease transgenic mice model [15].…”

Section: Introductionmentioning

confidence: 99%

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

et al. 2020

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Background: Consumption of plant-derived nutraceuticals and crude drugs in Arab traditional medicine is widely believed to confer beneficial effects in liver and kidney diseases. Fruits from the date palm Phoenix dactylifera L. are a rich source of nutrients and bioactive phytochemicals which possess a myriad of pharmacological effects. Herein, we examined the impact of Date Palm Pollen (DPP) aqueous suspension treatment on paracetamol (APAP) [Acetaminophen (APAP)] triggered hepatorenal damage in rats and further explored the underlying putative mechanism. Methods: Thirty Wistar rats were assigned to five groups (n = 6/group). Group I was control group; animals in group II were administered APAP 1000 mg/kg body weight (b.w.) intraperitonealy (i.p.); Group III and IV administered APAP plus date palm pollen with doses of 50, 100 mg/kg b.w and group V were administered APAP plus Silymarin (SIL) 10 mg/kg b.w. (i.p) respectively. Various biochemical parameters and histological assessment were evaluated in serum and tissue homogenate. Results: Pretreatment with DPP aqueous suspensions (50 and 100 mg/kg b.w.) significantly (p < 0.05) thwarted APAP triggered alterations in serum biomarkers of liver damage [aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP)], serum albumin as well as bilirubin. DPP treatment further mitigated APAP triggered dyslipidemia associated with hepatic damage by influencing APAP elicited changes in serum levels of cholesterol, triglycerides, HDL, LDL and VLDL. DPP treatment significantly (p < 0.05) ameliorated extrahepatic manifestations of APAP toxicity by influencing alterations in parameters of renal function (creatinine, urea and uric acid) as well serum electrolytes (Sodium, Potassium and Calcium). DPP treatment further influenced APAP-induced histological lesions by curtailing necrosis and inflammatory changes in the hepatic and renal architecture, respectively. Furthermore, DPP treatment modulated APAP-induced redox imbalance in the hepatic and renal tissue by blunting the increase of malondialdehyde (MDA) as well as decrease of nonprotein sulfhydryls (NP-SH) significantly (p < 0.05) when compared with control. The protective effect of DPP was further confirmed histologically. Conclusions: The present observations point to an hepatorenal protective effects of acute DPP treatment in APAP-intoxicated rats which is underpinned by its robust antioxidant properties.

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“…The overall findings of this study suggest that INH presents a circadian variation in renal toxicity dependent on dosing-time. This must be considered when this medication is administered to patients to manage INH toxic effects [50,51].…”

mentioning

confidence: 99%

Temporal Variation in Murine Kidney Toxicity to the Antituberculosis Agent (Isoniazid)

Souayed¹,

Haouas²,

Souid³

et al. 2018

Eur J Exp Bio

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Background: Isoniazid is a drug largely used for both the treatment and prophylaxis of Tuberculosis. In this study, we investigated whether INH-induced nephrotoxicity is influenced by dosing-time. Materials and Methods:A potentially toxic INH dose (120 mg/kg) was injected by i.p. route to different groups of animals at three different circadian times: 1, 9 and 17 hours after light onset (HALO). INH administration at 1 and 9 HALO resulted in maximum and minimum nephrotoxicity respectively. Toxicity was assessed by the significant increase in both biochemical parameters of kidney function (Urea: URE, Uric Acid: URI and Creatinine: CERT) and stress oxidative (Malondialdehyde: MDA). These results were correlated with the severe and minor renal histopathological observed at 1 and at 9 HALO respectively. Conclusion:The optimal tolerance or least side effects were detected when INH was injected in the second part of the light-rest span (9 HALO) of mice.

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Oxidative damage and alterations in antioxidant enzyme activities in the kidneys of rat exposed to trichloroacetic acid: protective role of date palm fruit

Cited by 10 publications

References 52 publications

Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats

Ameliorative effect of vitamin E on trichloroethylene-induced nephrotoxicity in rats

Impact of date palm pollen (Phoenix dactylifera) treatment on paracetamol-induced hepatorenal toxicity in rats

Temporal Variation in Murine Kidney Toxicity to the Antituberculosis Agent (Isoniazid)

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