Oxidative damage of plasma proteins and lipids in epidemic dropsy patients: Alterations in antioxidant status

Das, Mukul; Babu, K. Nagur; Reddy, Naveen P.; Srivastava, Lalit M.

doi:10.1016/j.bbagen.2004.12.014

Cited by 51 publications

(30 citation statements)

References 33 publications

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“…Conversely, a long-term elevation in ROS level in tissues is associated with damage to large molecules including DNA, proteins, and lipids. 20,21 In addition, ROS have been reported to be involved in signal transduction. 22,23 Hence, high ROS levels can damage cell structure and function, and can induce apoptosis or necrosis, which may ultimately result in pathological changes and lead to organ dysfunction or cancers.…”

Section: Discussionmentioning

confidence: 99%

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Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Ma¹,

Luo²,

Chen³

et al. 2012

IJN

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Because of its unique magnetic properties, the iron oxide (Fe 3 O 4 ) nanoparticle has been widely exploited and its application in various fields has promised immense benefits. However, doubts exist over the use of Fe 3 O 4 -nanoparticles in human beings. Thus, the aim of the current study was to find out the potential safety range of medical use. Twenty-five Kunming mice were exposed to Fe 3 O 4 -nanoparticles via intraperitoneal injection daily for 1 week at doses of 0, 5, 10, 20, and 40 mg/kg. Hepatic and renal tissues were sliced for physiological observation. Injuries were observed in the high-dose groups (20 and 40 mg/kg) compared with the control group (0 mg/kg). Biomarkers of reactive oxygen species, glutathione, malondialdehyde, DNAprotein crosslinks, and 8-hydroxy-2′-deoxyguanosine in the hepatic and renal tissues were detected. Injury to tissues and oxidative damage to cells at the molecular level was found. The safest dose recommended from the results of this study is 5 mg/kg, as we believe this to be an upper limit balancing the benefits and risks for sub-long-term exposure.

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Section: Discussionmentioning

confidence: 99%

“…The mice were given free access to mouse chow and water. The groups were separated by nanoparticle exposure dose (5,10,20, and 40 mg/kg, respectively) and a phosphatebuffered saline (PBS; control) group. The volume of nanoparticles administered to mice depended on their weights in the proportion of 1% mL/g.…”

Section: Animals and Groupingmentioning

confidence: 99%

Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Ma¹,

Luo²,

Chen³

et al. 2012

IJN

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“…2,7 Argemone oil (AO) is known to cause dilatation of the smaller arterioles and capillaries, leading to the leakage of serum proteins resulting in altered osmosis, edema formation and increased capillary damage. 8,9 Our experimental and clinical studies suggest that reactive oxygen species (ROS) are involved in the toxicity of AO, thereby leading to a decrease in the bio-antioxidant pool and antioxidant defense capacity. [9][10][11] The toxic effects of AO are due to the presence of interconvertible methylenedioxy phenyl alkaloids, sanguinarine/dihydro-sanguinarine 12 that have also been implicated to cause cellular macromolecular damage.…”

mentioning

confidence: 99%

“…8,9 Our experimental and clinical studies suggest that reactive oxygen species (ROS) are involved in the toxicity of AO, thereby leading to a decrease in the bio-antioxidant pool and antioxidant defense capacity. [9][10][11] The toxic effects of AO are due to the presence of interconvertible methylenedioxy phenyl alkaloids, sanguinarine/dihydro-sanguinarine 12 that have also been implicated to cause cellular macromolecular damage. 9 It has been observed that the incidence of hepatobiliary/gall bladder cancers is significantly more in the northern states belonging to Gangetic basin than in other states of India.…”

mentioning

confidence: 99%

“…[9][10][11] The toxic effects of AO are due to the presence of interconvertible methylenedioxy phenyl alkaloids, sanguinarine/dihydro-sanguinarine 12 that have also been implicated to cause cellular macromolecular damage. 9 It has been observed that the incidence of hepatobiliary/gall bladder cancers is significantly more in the northern states belonging to Gangetic basin than in other states of India. 13,14 It is feared that this may be due to the dietary habits of the population of Gangetic basin where usage of mustard oil is one of the major differences.…”

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confidence: 99%

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Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice

Das

Ansari

Dhawan

et al. 2005

Intl Journal of Cancer

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In recent times, a higher incidence of gall bladder carcinoma in the Indo‐Gangetic basin has been linked with the consumption of contaminated mustard oil. Consumption of mustard oil contaminated with argemone oil (AO) is well known to cause clinical manifestation referred to as “epidemic dropsy.” Because sanguinarine, an active alkaloid of AO, has been shown to intercalate DNA, a possible correlation of DNA damage in epidemic dropsy patients to tumorigenic potential of AO and isolated sanguinarine alkaloid in mice was investigated in the present study. Single topical application of AO (0.15–0.3 ml) or isolated sanguinarine (4.5–18 μmol) followed by twice‐weekly application of tetradecanoylphorbolmyristate acetate (TPA) for 25 weeks resulted in formation of tumors. Histopathologically these tumors were of squamous cell carcinoma type and similar to those found in the positive control group using dimethylbenzanthracene (DMBA)/TPA. The activities of cutaneous γ‐glutamyl transpeptidase (GGT) and glutathione‐S‐transferase P (GST‐P), marker enzymes of tumorigenesis, were found to exhibit higher expression in AO or isolated sanguinarine/TPA treated groups when compared to control. The higher expression of p53 and p21/WAF1 in skin after single topical application of AO or isolated sanguinarine further confirms the tumorigenic response. Single topical application of AO or isolated sanguinarine alkaloid to mice showed significant DNA damage in terms of Olive tail moment (89–129%), tail length (54%) and tail DNA (153–205%) using Comet assay in skin cells. Further, the extent of DNA damage in blood cells of epidemic dropsy patients in alkaline Comet assay was found to be significantly higher as compared to normal population, indicating the genotoxic response of AO exposure. Although the genotoxic lesions may be repaired to some extent on withdrawal of consumption of AO contaminated mustard oil and the residual genotoxic effects caused by AO may not be expressed as signs of carcinogenesis. Environmental factors or hormonal changes during aging process may lead to stimulate/promote the genetically altered latent cells to form neoplastic lesions and can act as one of the etiological factors responsible for higher incidence of gall bladder carcinoma in the population of Indo‐Gangetic basin. © 2005 Wiley‐Liss, Inc.

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Food Contamination

Barceloux

Faact²,

Facmt³

2008

Medical Toxicology of Natural Substances

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Oxidative damage of plasma proteins and lipids in epidemic dropsy patients: Alterations in antioxidant status

Cited by 51 publications

References 33 publications

Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Intraperitoneal injection of magnetic Fe3O4-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice

Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice

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