Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication

Abraham, Premila; Wilfred, G.; Cathrine, S.P.

doi:10.1016/s0009-8981(99)00140-0

Cited by 145 publications

(141 citation statements)

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“…CCl 4 is a common industrial solvent which is well-known for its hepatotoxicity [7-9]. CCl 4 is commonly used for free radical induced liver injury.…”

Section: Introductionmentioning

confidence: 99%

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

et al. 2010

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BackgroundCarbon tetra chloride (CCl4), an industrial solvent, is a hepatotoxic agent and it is the well established animal model for free radical-induced liver injury. The present investigation was carried out to establish the protective effect of natansnin, a novel dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver.ResultsCCl4 significantly increased the levels of lipid peroxides, oxidized glutathione and decreased the levels of reduced glutathione, SOD and CAT. CCl4 induce marked histopathological changes and increase in the levels of apoptotic proteins. CCl4 treatment significantly increased the levels of apoptotic proteins such as caspases-3, PARP, Bax, Bid and cytochrome C and also increased the levels of inflammatory mediators iNos and Cox-2. Natansnin treatment significantly decreased the levels of CCl4 induced apoptotic proteins and inflammatory mediators. Further natansinin treatment significantly inhibited the CCl4 induced apoptosis which was evident form the reduced TUNEL positive cells.ConclusionsIn conclusion, our study demonstrated the protective effect of natansnin against CCl4 induced oxidative stress and cellular degeneration in rat liver tissue. This protective effect of natansnin can be correlated to its direct antioxidant effect.

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“…CCl 4 is a common industrial solvent which is well-known for its hepatotoxicity [7-9]. CCl 4 is commonly used for free radical induced liver injury.…”

Section: Introductionmentioning

confidence: 99%

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

et al. 2010

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“…CCl 4 metabolism occurs primarily in the liver (and to a smaller extent in other organs that contain a high amount of cytochrome P450, such as the kidney). The trichloromethyl radical, which is formed from the metabolism of CCl 4 by the cytochrome P450 enzyme, reacts rapidly with molecular oxygen to produce the trichloromethyl peroxyl radical which triggers oxidative damage to macromolecular structures in cells [1]. The trichloromethyl radical itself can also cause adduct formation and subsequent molecular damage.…”

Section: Introductionmentioning

confidence: 99%

“…The trichloromethyl radical itself can also cause adduct formation and subsequent molecular damage. In the liver, molecular damage induced by CCl 4 can take the form of lipid peroxidation, steatosis, fibrosis, cirrhosis, hepatocellular carcinoma and liver failure in extreme cases [1,2]. CCl 4 damages the kidney in a similar fashion as the liver, causing oxidative damage as well as histological alterations [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…However, there is limited knowledge on the ability of Dennettia tripetala to prevent liver and kidney damage. In view of the phytochemical constituents of Dennettia tripetala, and the proven in vitro antioxidant activity of this plant, we carried out this study to investigate the potential of the ethanolic extract of this plant in preventing the liver and kidney of rats from undergoing free-radical damage caused by a single administration of CCl 4 .…”

Section: Introductionmentioning

confidence: 99%

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Pre-Exposure to <i>Dennettia tripetala</i> Ethanolic Fruit Extract Prevents Biochemical Alterations in Rats Subsequently Exposed to a Single Dose of Carbon Tetrachloride

Iseghohi

Orhue

Omage

2017

IJPPE

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Abstract. Dennettia tripetala (DT) is consumed in West Africa as a spice. It is also used in traditional medicine for treating cough, fever and other ailments. Its fruits have been shown to possess phytochemicals with proven antioxidant capabilities. DT roots elicit in vitro antioxidant capabilities similar to that of ascorbic acid. In this study, we evaluated the potency of the ethanol extract of DT fruits in preventing liver damage induced by a single oral administration of Carbon tetrachloride (CCl 4 ). Thirty female Wistar albino rats were randomized into six groups of five animals each: Group A served as control, Groups B-D were given increasing doses (250, 500 and 1000mg/kg b.w respectively) of DT extract for 14 days by gavage; on day 15, they were given CCl 4

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“…CCl 4 intoxication is also associated with chronic modifications in hemodynamics and changes in vascular function (Castro et al 1994;Mathie et al 1996a,b;Atucha et al 2000;Babál et al 2006). The process of intoxication with this toxic substance includes free radical formation that results in lipoperoxidation and oxidative stress (Abraham et al 1999). Several natural products having the antioxidant properties, including ginkgo biloba, propolis component and black tea extracts have been reported to reduce CCl 4 -induced nephrotoxicity and hepatotoxicity (Bahcecioglu et al 1999;Fadhel and Amran 2002;Ogeturk et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication

Čačányiová¹,

Pecháňová²,

Babál³

et al. 2011

gpb

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Abstract. The aim of the study was to evaluate the effect of red wine polyphenols extract Provinols TM on the development of cardiovascular injury in the model of carbon tetrachloride (CCl 4 ) intoxication. We followed the thoracic aorta vasoactivity and left ventricle nitric oxide (NO) synthase activity in male Wistar rats. In the preventive experiment lasting for 12 weeks the control group, the group receiving CCl 4 (0.5 ml/kg) two times a week subcutaneously, the group receiving Provinols TM (30 mg/kg/day) in drinking water and the group receiving CCl 4 +Provinols TM was used. In the recovery experiment, the initial 12 weeks of CCl 4 treatment were followed by 3 weeks of spontaneous recovery or recovery with Provinols TM . CCl 4 -intoxication resulted in the injury of vasoactivity which was demonstrated by the inhibition of acetylcholine-induced relaxation as well as noradrenaline-induced contraction. In the preventive as well as recovery experiment administration of polyphenols refreshed endotheliumdependent relaxant response and normalized inhibited contraction to adrenergic stimuli. Provinols TM treatment significantly increased NO-synthase activity in all groups. The results revealed beneficial effects of red wine polyphenols on vascular function injured by chronic CCl 4 intoxication. The correction of endothelial function seems to be attributed to the activation of NO pathway by polyphenols.

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Oxidative damage to the lipids and proteins of the lungs, testis and kidney of rats during carbon tetrachloride intoxication

Cited by 145 publications

References 9 publications

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver

Pre-Exposure to <i>Dennettia tripetala</i> Ethanolic Fruit Extract Prevents Biochemical Alterations in Rats Subsequently Exposed to a Single Dose of Carbon Tetrachloride

Red wine polyphenols correct vascular function injured by chronic carbon tetrachloride intoxication

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