Oxidative DNA cleavage induced by an iron(III) flavonoid complex: Synthesis, crystal structure and characterization of chlorobis(flavonolato)(methanol) iron(III) complex

Amrani, Fátima Ben Allal El; Perelló, L.; Real, José Antonio; González‐Álvarez, Marta; Alzuet, Gloria; Borrás, Joaquı́n; García-Granda, Santiago; Montejo-Bernardo, José

doi:10.1016/j.jinorgbio.2006.01.036

Cited by 86 publications

(53 citation statements)

References 47 publications

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“…The ν (C O) peak for A 5 , A 7 and A 8 was observed at ∼1680 cm −1 (cyclic) and ∼1660 cm −1 (acetyl), shifted to 1574 cm −1 on formation of mixed-ligand complexes. [23] These data are further supported by the ν (M-O) band's appearance at ∼510 cm −1 . The band at about 3420 cm −1 for the ν OH frequency indicates the coordinated hydroxo anion to iron, and is further supported by the shoulder at about 29 400 cm −1 in UV-vis spectra.…”

Section: Ir Spectramentioning

confidence: 65%

Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes

Patel

Pansuriya

Chhasatia

2008

Applied Organom Chemis

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The mixed-ligand complexes of iron(III) with 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid and various neutral bidentate Schiff base ligands were prepared. The structure of mixed-ligand complexes was investigated using spectral, physicochemical and elemental analyses. Biocidal activity was determined using agar plate technique against Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Salmonella typhi, Escherichia coli and Serratia marcescens. The result showed a significant increase in a biocidal activity compared with parent ligands, metal salts and standard drugs (ofloxacin, levofloxacin). DNA binding and cleavage studies were carried out using absorption titration and gel electrophoresis techniques, respectively. The binding constant of Fe(III) complexes was obtained in the range 2.5-4.0 × 10 4 M −1 . The DNA binding and cleavage efficacy were raised in mixed-ligand complexes as compared with parental ligands and metal salts.

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Section: Ir Spectramentioning

confidence: 65%

Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes

Patel

Pansuriya

Chhasatia

2008

Applied Organom Chemis

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“…A representative of this group is pyrazole, which has found applications in pharmacotherapy (22). The chemical literature contains many data on the possible practical applications of the compounds with a pyrazole ring, which are used, for example, in agriculture as herbicides, fungicides and pesticides, in the industry as photo-stabilisers and in therapy as antibacterial agents, non-narcotic analgesics, anticancer agents and antipyretic agents (21,23). It should be noted that among pyrazole derivatives used in therapy, there is a correlation between their pharmacological activity and chemical structure.…”

Section: Resultsmentioning

confidence: 99%

“…It is contained in Detralex. Pyrazole derivatives also display a wide spectrum of biological activity and also have high ability to create coordination compounds with transient metal ions such as Cu(II), Ru(III), Pt(II), Co(II), Pd(II) (11,12,13,14). In the recent years, there has been much chemical research as a result of which complexes of metals with pyrazole derivatives were obtained.…”

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confidence: 99%

Effect of Cu(II) Coordination Compounds on the Activity of Antioxidant Enzymes Catalase and Superoxide Dismutase in Patients with Colorectal Cancer

Kubiak

Malinowska

Langer

et al. 2011

Polish Journal of Surgery

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2Kierownik: prof. dr hab. a. dzikiColorectal cancer (CRC) is a serious medical and economical problem of our times. It is the most common gastrointestinal cancer in the world. In Poland, the treatment and detection of CRC are poorly developed and the pathogenesis is still unclear. One hypothesis suggests a role of reactive oxygen species (ROS) in the pathogenesis of CRC. Experimental studies in recent years confirm the participation of ROS in the initiation and promotion of CRC. the aim of the study was to examine the effect of the following coordination compounds coordination compounds: dinitrate (V) tetra(3,4,5-trimethyl-n 1 -pyrazole-ĸn 2

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“…Chemical compounds such as chromones, pyrazoles or flavones readily form complexes with transient metal ions (16,17,18). One of the primary applications for such derivatives is in medicine where these are used e.g.…”

Section: Discussionmentioning

confidence: 99%

Biological Properties Of Benzopyran-Based Platinum (Ii) Complexes

Malinowska¹,

Modranka²,

Majsterek³

et al. 2014

Polish Journal of Surgery

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the aim of the study was to analyze the physicochemical synthesized complex 3 [(1,3-thiazol -2-ylimino) methyl)]-4H-chromene -4 -one with tetrachloroplatinate(II) dipotassium and determination peroxidase activity and glutathione (GPX) in red blood cells of cancer patients and healthy subjects. Results. The study was an increase of activity in the control without the compound and after the introduction of the complex relative to the treatment groups. In healthy subjects, without the use of glutathione peroxidase complex averaged 73.25 ± 23.88 U / g Hb after application of the compound corresponds to the reference group 81.01 ± 25.94 U / g Hb. In contrast, in patients without the use of the complex activity amounted to 42.85 ± 27.49 U / g Hb. In the study group, which uses synthesized complex GPX activity corresponds to 67.72 ± 13.44 U / g Hb. conclusions. The obtained results underline that the introduction of significant blood antioxidant complex research has a significant impact on the results of the determinations. Statistically significant (p < 0.05) difference occurred in both test and no relation to the administration of the complex in relation to the control of 1. 2.

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Oxidative DNA cleavage induced by an iron(III) flavonoid complex: Synthesis, crystal structure and characterization of chlorobis(flavonolato)(methanol) iron(III) complex

Cited by 86 publications

References 47 publications

Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes

Synthesis, spectroscopy, thermal and biological aspect of novel six‐coordinated dimeric iron(III) mixed‐ligand complexes

Effect of Cu(II) Coordination Compounds on the Activity of Antioxidant Enzymes Catalase and Superoxide Dismutase in Patients with Colorectal Cancer

Biological Properties Of Benzopyran-Based Platinum (Ii) Complexes

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