Oxidative effects on lung inflammatory response in rats exposed to different concentrations of formaldehyde

Murta, Giselle Luciane; Campos, Keila Karine Duarte; Bandeira, Ana Carla Balthar; Diniz, Mirla Fiuza; Costa, Guilherme de Paula; Costa, Daniela Caldeira; Talvani, André; Lima, Wanderson Geraldo de; Bezerra, Frank Silva

doi:10.1016/j.envpol.2015.12.054

Cited by 45 publications

(24 citation statements)

References 55 publications

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“…Chemicals may also exert their genotoxic effects in lymphocytes indirectly via induction of inflammation-generated reactive oxygen species or activation of procarcinogens. [21][22][23][24][25].…”

Section: Routes By Which Lymphocytes In the Body Can Be Exposed To Exmentioning

confidence: 98%

Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans

Fenech

Knasmueller

Bolognesi

et al. 2016

Mutation Research/Reviews in Mutation Research

118

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Section: Routes By Which Lymphocytes In the Body Can Be Exposed To Exmentioning

confidence: 98%

Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans

Fenech

Knasmueller

Bolognesi

et al. 2016

Mutation Research/Reviews in Mutation Research

118

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“…Thus, the stereological analyses of our study corroborate the results obtained by cell counts in BALF. We observed an increase in alveolar volume density and a decrease in alveolar septa volume density, which are characteristics that indicate the presence of acute pulmonary inflammation and are related to the production of matrix metalloproteinases by inflammatory cells 57. Therefore, the administration of a high-refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to CS.…”

Section: Discussionmentioning

confidence: 63%

The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke

Peña¹,

Ramos²,

Soares³

et al. 2016

COPD

Self Cite

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This study aimed to evaluate the effects of a high refined carbohydrate diet and pulmonary inflammatory response in C57BL/6 mice exposed to cigarette smoke (CS). Twenty-four male mice were divided into four groups: control group (CG), which received a standard diet; cigarette smoke group (CSG), which was exposed to CS; a high refined carbohydrate diet group (RG), which received a high refined carbohydrate diet; and a high refined carbohydrates diet and cigarette smoke group (RCSG), which received a high refined carbohydrate diet and was exposed to CS. The animals were monitored for food intake and body weight gain for 12 weeks. After this period, the CSG and RCSG were exposed to CS for five consecutive days. At the end of the experimental protocol, all animals were euthanized for subsequent analyses. There was an increase of inflammatory cells in the bronchoalveolar lavage fluid (BALF) of CSG compared to CG and RCSG compared to CG, CSG, and RG. In addition, in the BALF, there was an increase of tumor necrosis factor alpha in RCSG compared to CG, CSG, and RG; interferon gamma increase in RCSG compared to the CSG; and increase in interleukin-10 in RCSG compared to CG and RG. Lipid peroxidation increased in RCSG compared to CG, CSG, and RG. Furthermore, the oxidation of proteins increased in CSG compared to CG. The analysis of oxidative stress showed an increase in superoxide dismutase in RCSG compared to CG, CSG, and RG and an increase in the catalase activity in RCSG compared with CG. In addition, there was a decrease in the glutathione reduced/glutathione total ratio of CSG, RG, and RCSG compared to CG. Therefore, the administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to CS.

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“…Results of Murta et al (2016) point out to the potential of formaldehyde in promoting airway injury by increasing the inflammatory process as well as by the redox imbalance [an increase of macrophages and lymphocytes, NADPH oxidase in the blood, activity of superoxide dismutase (SOD) and catalase, total glutathione (tGSH), reduced glutathione (GSH) and oxidized glutathione (GSSG), an increase in lipid peroxidation and CCl 2 , CCl 3 and CCl 5 chemokines, as well as decrease of the reduced/oxidized glutathione ratio (GSH/GSSG)]. Yu et al (2014) have suggested that a certain concentration of formaldehyde (20, 40, 80 mg/m 3 ) for 15 days in the respective inhalation chambers could have toxic effects on the hematopoietic system, with oxidative stress as a critical effect.…”

Section: Discussionmentioning

confidence: 91%

Evaluation of oxidative stress markers in the heart and liver of rainbow trout (Oncorhynchus mykiss walbaum) exposed to the formalin

Tkachenko

Grudniewska

2016

Fish Physiol Biochem

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The aim of this study was to examine change in lipid and protein oxidation biomarkers, transamination enzymes and lactate dehydrogenase activities, lactate and pyruvate levels in liver and heart tissue of rainbow trout (Oncorhynchus mykiss Walbaum) that was exposed to formalin baths. Increase of 2-thiobarbituric acid reactive substances and carbonyl derivatives of protein oxidative destruction was noticed only in cardiac tissue of formalin-exposed fish. Activity of lactate dehydrogenase and lactate level in the cardiac tissue were elevated, indicating active glycolysis. Effects of formalin disinfection were different in both tissues. Aldehydic and ketonic derivatives of oxidatively modified proteins in liver were consistently reduced upon exposure to the formalin. In support of this, decrease in alanine and aspartate aminotransferases was noticed. Formalin disinfection of rainbow trout results in metabolic plasticity, predominantly in liver with decreased levels of oxidative stress biomarkers and aminotransferases activity. Formalin-induced oxidative stress in the cardiac tissue was more considerable.

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Oxidative effects on lung inflammatory response in rats exposed to different concentrations of formaldehyde

Cited by 45 publications

References 55 publications

Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans

Molecular mechanisms by which in vivo exposure to exogenous chemical genotoxic agents can lead to micronucleus formation in lymphocytes in vivo and ex vivo in humans

The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke

Evaluation of oxidative stress markers in the heart and liver of rainbow trout (Oncorhynchus mykiss walbaum) exposed to the formalin

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