Oxidative status and DNA damage in operating room personnel

Baysal, Zeynep; Cengiz, Mustafa; Ozgonul, Abdullah; Cakir, Muslum; Çelik, Hakim; Koçyiğit, Abdürrahim

doi:10.1016/j.clinbiochem.2008.09.103

Cited by 35 publications

(31 citation statements)

References 24 publications

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“…Many studies have suggested that chronic exposure to trace levels of anesthetic gas is harmful to operating room personnel despite developed scavenging systems [2,[17][18][19][20]. To our knowledge, this is the first study to interpret the association between impaired oxidative balance and HDL-related PON1, ARE enzyme activity, and AP.…”

Section: Discussionmentioning

confidence: 87%

“…Many clinical observations using different methods have reached the conclusion that oxidative stress had increased in AP [2,[17][18][19][20]. Serum (or plasma) concentrations of different oxidants and antioxidants can be measured separately in laboratories, but these measurements are labor-intensive, time-consuming, costly, and require specialized personnel.…”

Section: Control_tos Ap_osi Control_osimentioning

confidence: 99%

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Arylestarase and Oxidative Stress in Operating Room Personnel

Cerit¹,

Onuk²,

Elli̇dağ³

et al. 2014

Adv Clin Exp Med

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Background. Long-term occupational exposure to trace concentrations of volatile anesthetics is known to have adverse effects on the health of exposed personnel. Objectives. We investigated paraoxonase-1 (PON1) and arylesterase (ARE), as well as antioxidant status (TAS) and total oxidant status (TOS) levels in anesthesia personnel (AP) who were chronically exposed to inhalation anesthetics, and compared them with levels in a control group. Material and Methods. We designed a comparative prospective study with 50 female subjects. The first cohort included 25 full-time female workers in operating rooms in two locations in the Antalya Education and Research Hospital in Antalya, Turkey. The control group was comprised of 25 female individuals working in the same hospitals without any work-related exposure to hazardous agents. Results. Serum ARE activity and TAS levels were significantly reduced (p = 0.04 and p < 0.0001, respectively), whereas TOS and OSI levels were found to be significantly higher (p = 0.01 and p < 0.0001, respectively) in AP. However, there were no significant differences in PON1 activity, PON1/HDL-C, ARE/HDL-C, and PON1/ /ARE (p = 0.30, p = 0.5, p = 0.1 and p = 0.7, respectively) when the two groups were contrasted. Conclusions. According to the results of this study, depending on the putative role of PON/ARE in oxidant stress--related diseases, particularly atherosclerosis and cancer, AP might be considered a risk group for the development of atherosclerosis and many other diseases (Adv Clin Exp Med 2014, 23, 1, 49-55).

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Section: Discussionmentioning

confidence: 87%

Section: Control_tos Ap_osi Control_osimentioning

confidence: 99%

Arylestarase and Oxidative Stress in Operating Room Personnel

Cerit¹,

Onuk²,

Elli̇dağ³

et al. 2014

Adv Clin Exp Med

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“…ROS are small, highly reactive, oxygen-containing molecules that are naturally generated in small amounts during the body's metabolic reactions and can react with and damage complex cellular molecules such as lipids, proteins, or DNA [7,34]. Increased DNA damage in silver jewelry workers may be due to interaction with DNA of silver particles or nanosilver [9], overproduction of ROS [7], or decreased excretion of oxidant substances [14].…”

Section: Discussionmentioning

confidence: 99%

Increased DNA Damage and Oxidative Stress Among Silver Jewelry Workers

Aktepe

Koçyiğit

Yükselten

et al. 2015

Biol Trace Elem Res

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Silver has long been valued as a precious metal, and it is used to make ornaments, jewelry, high-value tableware, utensils, and currency coins. Human exposures to silver and silver compounds can occur oral, dermal, or by inhalation. In this study, we investigated genotoxic and oxidative effects of silver exposure among silver jewelry workers. DNA damage in peripheral mononuclear leukocytes was measured by using the comet assay. Serum total antioxidative status (TAS), total oxidative status (TOS), total thiol contents, and ceruloplasmin levels were measured by using colorimetric methods among silver jewelry workers. Moreover, oxidative stress index (OSI) was calculated. Results were compared with non-exposed healthy subjects. The mean values of mononuclear leukocyte DNA damage were significantly higher than control subjects (p < 0.001). Serum TOS, OSI, and ceruloplasmin levels were also found to be higher in silver particles exposed group than those of non-exposed group (p < 0.001, p < 0.001, p < 0.01, respectively). However, serum TAS levels and total thiol contents of silver exposed group were found significantly lower (p < 0.05, p < 0.001, respectively). Exposure to silver particles among silver jewelry workers caused oxidative stress and accumulation of severe DNA damage.

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“…Antioxidant enzymes and trace elements in operating room personnel exposed to a mixture of volatile anesthetics have been reported to be lower than in a non-exposed group 20 . Moreover, anesthesiologists, nurses and surgeons exposed to halothane, isoflurane, sevoflurane, desflurane and N 2 O for a mean of seven years have shown increased DNA damage and oxidative status 21 .…”

Section: Introductionmentioning

confidence: 99%

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

et al. 2014

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PURPOSE:To investigate the effects of occupational exposure to waste anesthetic gases on genetic material and antioxidant status in professionals during their medical residency. METHODS:The study group consisted of 15 medical residents from Anesthesiology and Surgery areas, of both genders, mainly exposed to isoflurane and to a lesser degree to sevoflurane and nitrous oxide; the control group consisted of 15 young adults not exposed to anesthetics. Blood samples were drawn from professionals during medical residency (eight, 16 and 22 months of exposure to waste anesthetic gases). DNA damage was evaluated by comet assay, and antioxidant defense was assessed by total thiols and the enzymes glutathione peroxidase (GPX), superoxide dismutase (SOD) and catalase (CAT). RESULTS:When comparing the two groups, DNA damage was significantly increased at all time points evaluated in the exposed group; plasma thiols increased at 22 months of exposure and GPX was higher at 16 and 22 months of exposure.CONCLUSION: Young professionals exposed to waste anesthetic gases in operating rooms without adequate scavenging system have increased DNA damage and changes in redox status during medical residency. There is a need to minimize exposure to inhalation anesthetics and to provide better work conditions.

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Oxidative status and DNA damage in operating room personnel

Cited by 35 publications

References 24 publications

Arylestarase and Oxidative Stress in Operating Room Personnel

Arylestarase and Oxidative Stress in Operating Room Personnel

Increased DNA Damage and Oxidative Stress Among Silver Jewelry Workers

DNA damage and antioxidant status in medical residents occupationally exposed to waste anesthetic gases

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