Oxidative stress after acute and sub-chronic malathion intoxication in Wistar rats

Possamai, Fabricio Pagani; Fortunato, Jucélia Jeremias; Feier, Gustavo; Agostinho, Fabiano R.; Quevedo, João; Filho, Danilo Wilhelm; Dal‐Pizzol, Felipe

doi:10.1016/j.etap.2006.09.003

Cited by 142 publications

(95 citation statements)

References 32 publications

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“…It is also possible that NAC improved the survival rate for another reason; it may have prevented lung-related pathological conditions such as shortness of breath or obstructive pulmonary conditions. Possami et al (19) showed that the most sensitive targets of oxidative damage after acute treatment with malathion (a mild toxic OP) were the kidneys, lungs and diaphragm, as well as the liver, quadriceps and serum after subchronic treatment. Moreover, mortality by OP intoxication is mainly caused by respiratory obstruction, This is an issue that has been completely ignored.…”

Section: Oxidative Stress and Use Of Antioxidants In Op Poisoningmentioning

confidence: 99%

“…The role of oxygen-free radicals has been established in many chronic disorders, but their significance in acute conditions has not been given much attention. During recent years, oxidative stress has been described as a co-lethal factor in OP-induced poisoning (17)(18)(19)(20)(21). Many reviews have stressed the role of oxidative stress in OP poisoning (15,(22)(23)(24)(25)(26).…”

Section: Oxidative Stress and Use Of Antioxidants In Op Poisoningmentioning

confidence: 99%

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Antioxidants in Organophosphorus Compounds Poisoning

Nurulain

Szegi

Tekes

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the role of antioxidants in reducing the mortality and morbidity induced by OP compounds has scarcely been verifi ed, as well as their role as adjunct treatment compounds for both structurally and functionally different OP compounds. The present review of the literature was undertaken to establish the role of antioxidants in survival studies following acute exposure to OP compounds. The review found no substantial evidence that antioxidants demonstrate any positive effect following extremely toxic poisoning. However, for a more comprehensive and rational conclusion, further research needs to be conducted. Nurulain SM et al. ANTIOXIDANTS AND ORGANOPHOSPHORUS POISONING Arh Hig Rada Toksikol 2013;64:169-177 KEY WORDS: acute poisoning, oxidative stress, survival study Intoxication by organophosphorus compoundsThe history of organophosphorus compounds (OP) and their poisonous effect stretches throughout more than a century. These compounds manifest their toxicity by irreversibly inhibiting the enzyme acetylcholinesterase at the nerve synapse. Despite decades-long research, mortality caused by acute OP poisoning continues to be high (1), while no new standard therapies are being introduced. There are over 150 different types of synthesized OPs, though their generalized structure is much the same. Each OP has a unique profile of toxicity and behaviour. For instance, death due to dichlorvos poisoning occurs very rapidly, while dimethoate toxicity takes several hours to develop (2), even though both belong to the same OP class. From the standpoint of chemistry, OP c o m p o u n d s c o m p r i s e o rg a n o p h o s p h a t e s , organophosphonates and organophosphinates, each of which is further divided into sub-groups. Other classifi cations of OPs are based on the lethality of a compound. According to the classifi cation of the World Health Organisation (WHO) (3), Class Ia belongs to extremely toxic OPs, Ib are highly toxic, Class II comprises moderately toxic, whereas Class III consists of mildly toxic OP compounds. Some examples are shown in Table 1. In addition, there are also the deadly organophosphorus chemical weapons (OPWs), called nerve agents.Acute organophosphate insecticide poisoning manifests itself through three different phases of toxicity; namely, acute cholinergic crisis, which occurs from within a few minutes to twenty-four hours;Brought to you by |

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Section: Oxidative Stress and Use Of Antioxidants In Op Poisoningmentioning

confidence: 99%

Section: Oxidative Stress and Use Of Antioxidants In Op Poisoningmentioning

confidence: 99%

Antioxidants in Organophosphorus Compounds Poisoning

Nurulain

Szegi

Tekes

et al. 2013

Archives of Industrial Hygiene and Toxicology

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“…AChE is an enzyme vital for normal nerve function and AChE inhibition leads to over stimulation of the central and peripheral nervous systems, resulting in neurotoxic effects in organisms. OPPs also produce oxidative stress in different tissues (Possamai et al, 2007) and shows genotoxic (Bolognesi, 2003;Cakir andSarikaya, 2005, Arredondo et al, 2008) and immunotoxic (Yeh, et al, 2005;Day et al, 1995) effects. The majority of OPPs give rise to only slight inhibition of AChE by themselves, unless they undergo oxidative activation.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Organophosphorus Pesticides and Their Degredation By-Products to Daphnia Magna, Lepidium Sativum and Vibrio Fischeri

Aydın¹,

Özcan²,

Bedük³

2011

Pesticides - The Impacts of Pesticides Exposure

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“…No entanto, elas também podem estar envolvidas em outros processos patológicos, como alteração no sistema imune e estresse oxidativo (KUJBIDA et al, 2006;KUJBIDA, 2008) As estruturas químicas, mecanismo de ação e gêneros produtores descritos das principais cianotoxinas estão apresentados na tabela 1. (POURIA et al, 1998;JOCHIMSEN et al, 1998). Este foi o primeiro caso confirmado de morte de seres humanos por contato com cianotoxinas (AZEVEDO et al, 1994 …”

Section: Cianobactérias E Cianotoxinasunclassified

“…A intoxicação aguda por IOF pode causar um aumento na formação de ROS provocando um desequilíbrio na homeostase celular e EO, tanto em humanos quanto em animais (AKHGARI et al, 2003;POSSAMAI et al, 2007). Alguns trabalhos demonstraram que o EO também desempenharia um papel importante na toxicidade dos IOF.…”

Section: Inseticidas Organofosforados E Estresse Oxidativounclassified

Investigação de mecanismos bioquímicos e fisiológicos em organismos expostos a anatoxina-a(s)

Salazar¹

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Aos meus queridos amigos Sidnei e Fabyana, por terem me oferecido mais que amizade, carinho, paciência e suporte emocional nas horas mais difíceis. Os laços que fizemos perdurarão para sempre, sem importar onde estivermos.Aos amigos que fiz durante a minha estadia em Portugal e na Alemanha, Prof. Dr.Bernd Luckas, Prof. Dr. Pflugmacher, Bernd, Zélia, Amélia, Denise, Guilherme, Silvia, Smith, Gláucio, Thomas e Anja, por me acolherem e ajudarem nos experimentos realizados.A minha querida tia Charo, embora não esteja mais presente, por ter sido a minha primeira incentivadora à leitura e à reflexão.vii Aos meus amigos do "Solar dos Príncipes" Fabriciano, Daniel, Tiago Peixe, Thiago e Rodrigo pela amizade e momentos de descontração.Aos funcionários do biotério do Departamento de Patologia da FMVZ-USP, Claudia, Hercula, Idalina e Rosiris, pelos cuidados dispensados aos animais utilizados neste trabalho, pelo auxílio e ótima convivência.Aos funcionários da secretaria de pós-graduação da FCF-USP, Sueli, Edna, Ana, Jorge e Elaine por estarem sempre prestes a esclarecer dúvidas e pela ajuda inestimável.Aos meus tios Hector, Yolanda e família (Anjo, Cris, Ameriney e Mayarinha), por terem me acolhido em GO e sempre estarem presentes quando precisei.Ao meu primo Nelson e família pelo constante apoio.As minhas queridas amigas, Marita, Charito e Patty pelo carinho e irmandade apesar da distância.Aos amigos Terezinha, Vavá e Luciana, por serem anjos que apareceram no meu caminho na hora certa.A todos os que tal vez não mencionei, mas que foram muito importantes na luta diária para atingir esta meta..... Meus agradecimentos viii RESUMO Investigação de mecanismos bioquímicos e fisiológicos em organismos expostos a anatoxina-a(s)A anatoxina-a(s) (antx-a(s)) é uma neurotoxina produzida por cianobactérias, cujo mecanismo de ação conhecido consiste na inibição irreversível da atividade da enzima acetilcolinesterase (AChE). Em razão da instabilidade da molécula e da inexistência de um padrão analítico, as informações referentes a presença dessa toxina nos reservatórios de água doce e, a completa elucidação dos processos envolvidos na sua toxicidade, são escassas.Na última década, a pesquisa referente a capacidade dos inseticidas organofosforados de induzir estresse oxidativo em humanos e animais tem sido bastante importante. Pelo fato da antx-a(s) ser o único organofosforado produzido por cianobactérias conhecido, este trabalho teve como objetivo investigar os mecanismos bioquímicos envolvidos na ação pró-oxidante de extratos aquosos contendo antx-a(s). A atividade das enzimas colinesterásicas AChE e butirilcolinesterase (BuChE) e, das enzimas antioxidantes catalase (CAT), glutationa peroxidase (GPx), glutationa redutase (GR) e superóxido dismutase (SOD) foram avaliadas em dois modelos experimentais: (i) Camundongos Swiss tratados por via intraperitoneal (ip) com uma dose sub-letal (20 mg.kg -1 ) de extrato contendo antx-a(s) e sacrificados após 24 h, 48 h, 7 e 14 dias e, (ii) sementes de alfafa regadas com extrato contendo antx-a(s) p...

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Oxidative stress after acute and sub-chronic malathion intoxication in Wistar rats

Cited by 142 publications

References 32 publications

Antioxidants in Organophosphorus Compounds Poisoning

Antioxidants in Organophosphorus Compounds Poisoning

Acute Toxicity of Organophosphorus Pesticides and Their Degredation By-Products to Daphnia Magna, Lepidium Sativum and Vibrio Fischeri

Investigação de mecanismos bioquímicos e fisiológicos em organismos expostos a anatoxina-a(s)

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