Oxidative Stress and Aging: Studies on an East-Sicilian, Ultraoctagenarian Population Living in Institutes or at Home

Maugeri, D.; Sant’Angelo, Antonino; Bonanno, Maria; Testai, M.; Abbate, Stefano; Giudice, Fabrizio Lo; Mamazza, C.; Puglisi, N; Panebianco, P.

doi:10.1016/j.archger.2004.04.037

Cited by 21 publications

(10 citation statements)

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“…Previous findings have shown an increased level of OxS among frail, institutionalized elderly individuals which may consequently result in an accelerated aging process, and elevated incidence of oxidative diseases including cancers, CVD, or dementia (18). Similar findings of increased oxidant parameters and a decrease in antioxidants in patients with MetS have been reported in previous studies (19)(20)(21).…”

Section: Discussionsupporting

confidence: 77%

“…An impaired antioxidant defense may result in elevation of ROS levels and impaired degradation, which eventually would directly and indirectly damage the organs. Therefore, OxS in aging, besides being directly linked to organ damage, would exacerbate the risk factors of vascular damage including MetS (3,18).…”

Section: Mda Tac ----------------------------------------------------mentioning

confidence: 99%

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Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

et al. 2017

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Abstract.The interconnection between aging and metabolic syndrome (MetS) and their effect on oxidative stress (OxS) status lacks adequate information. Additionally, the agerelated changes of antioxidant defenses and OxS in senior women with MetS in comparison to healthy senior women are not yet established. We analyzed the correlation between oxidative defense status and OxS with MetS components. Through further examination of MetS and aging, we aimed to determine their independent effects on OxS and oxidative defense status. This community-based cross-sectional study was conducted in the rural area of Babol, Iran. A total of 75 women of ≥60 years of age with MetS along with 89 women with similar conditions without the MetS, serving as the control group, were studied. Blood glucose, lipid profile, malondialdehyde (MDA) and total antioxidant capacity (TAC) were determined. Data were analyzed using multiple linear regression, ANOVA and independent t-tests. MDA and TAC levels independently showed a significant correlation with triglyceride (TG), waist circumference, fasting blood glucose and high-density lipoprotein cholesterol (HDL-C). As suggested by the standardized B (0.810, -0.783, P<0.001; -0.052, P<0.001, 0.047, P<0.01), TG followed by HDL-C were the most strongly correlated factors with MDA and TAC. Furthermore, MetS and age were independent risk factors for antioxidant activity reduction and OxS. However, MetS had a much higher predictive power than age (standardized B 0.573 for MetS and 0.376 for age, P<0.001). Aging and MetS, both lead to OxS, but the impact of MetS on this disorder was far greater than the effect of age. However, their cumulative effects can lead to a worsening of the situation.Therefore, early diagnosis and treatment of MetS, especially in the elderly can prevent any adverse impact of MetS.

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Section: Discussionsupporting

confidence: 77%

Section: Mda Tac ----------------------------------------------------mentioning

confidence: 99%

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

et al. 2017

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“…Numerous studies have demonstrated that oxidative stress is increased in frail, institutionalised elderly people, and may lead to an accelerated ageing and higher incidence of oxidative diseases such as cancers, CVD, or dementia (Maugeri et al, 2004). The current work addressed the relationships between oxidative stress and age in a freeliving healthy elderly population that represents an increasing segment of the general population in developed countries.…”

Section: Discussionmentioning

confidence: 99%

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

et al. 2005

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Objective: Oxidative stress has been reported to increase with ageing. However, the data in healthy humans remain controversial and studies in free-living elderly people are scarce. The objective of the present study was to compare age-related oxidative stress in late middle-aged and older free-living subjects. Design: The effect of ageing on oxidative stress and antioxidant parameters was investigated in 188 middle-aged subjects from Clermont-Ferrand (France) and Coleraine (UK), and in 199 older subjects from Grenoble (France) and Roma (Italy). Plasma thiol (SH) groups, define definition (TBAR's) and total glutathione (GSH), define definition (FRAP), and superoxide dismutase (SOD) activity were measured at baseline of the ZENITH study. Results: Plasma SH groups and FRAP and, surprisingly, TBAR's were significantly lower in free-living older subjects compared to younger subjects (Po0.001, Po0.001, Po0.01, respectively), but there was no significant differences in GSH levels. Conclusion: European free-living healthy older do not appear to be exposed to an acute oxidative stress. However, the highly significant positive correlation between plasma SH group oxidation or decreased FRAP and ageing is predictive of an increased risk of oxidative stress in older subjects. Moreover, the comparison between middle-aged and older subjects regarding oxidative stress parameters suggests also a progressive and slow decline of antioxidant status in healthy free-living older elderly and underline the impact on life-style factors on successful ageing.

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“…Ultraoctagenarian population was analysed by Maugeri et al [4] in order to reveal a possible correlation between the free radical levels and the psycho-physical health status. The statistically significant negative correlation between D-ROMS and the cognitive performance was demonstrated in this study.…”

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confidence: 99%

Airways oxidative stress, lung function and cognitive impairment in aging

Gramiccioni

Carpagnano

Spanevello

et al. 2016

Monaldi Arch Chest Dis

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Background. An altered balance of oxidants/anti-oxidants is one of the pathological mechanisms of many agedependent disorders. We aimed to investigate the age-related airways oxidative stress, using non invasive, safe and repeatable techniques; to evaluate the correspondence between systemic and local oxidative stress in healthy subjects of different age ranges; to analyse the correlation between systemic and local oxidative stress with lung function and with cognitive impairment. Methods. Thirty consecutive healthy high school graduated subjects (8 M, 22 F), divided in three ranges of age (60 years) were enrolled. All subjects underwent oxygen free radicals and exhaled nitric oxide measurement (by the diacron reactive oxygen metabolites test and by a rapid-response chemiluminescence nitric oxide analyzer), lung function tests, and cognitive impairment scales (Mini Mental State Examination and Geriatric Depression Scale). Results. A significant increase of oxygen free radicals, exhaled nitric oxide, and Geriatric Depression Scale score and a significant decrease of forced expiratory volume in 1 second and forced expiratory vital capacity from younger to older subjects were identified. Moreover, the significant positive correlation between oxygen free radicals and exhaled nitric oxide, and between oxygen free radicals and exhaled nitric oxide with Geriatric Depression Scale score were found. The significant negative correlation between forced expiratory volume in 1 second and oxygen free radicals or exhaled nitric oxide was also demonstrated. Conclusions. Our data supports the role of progressive local oxidative stress in damaging the lung function and in inducing depression symptoms.

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Oxidative Stress and Aging: Studies on an East-Sicilian, Ultraoctagenarian Population Living in Institutes or at Home

Cited by 21 publications

References 0 publications

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

Association of lipid peroxidation and antioxidant status with metabolic syndrome in Iranian healthy elderly women

Age-related oxidative stress and antioxidant parameters in middle-aged and older European subjects: the ZENITH study

Airways oxidative stress, lung function and cognitive impairment in aging

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