Oxidative Stress and Changes in α‐ and γ‐Tocopherol Levels during Coronary Artery Bypass Grafting

Abstract

We studied whether cardiopulmonary bypass (CPB) has any immediate impact on the initiation of antioxidative defenses in the body by measuring F(2)-isoprostanes and alpha- and gamma-tocopherol, respectively. 8-iso-PGF(2alpha) levels increased significantly within 3 minutes and until the end of CPB. alpha-Tocopherol levels increased gradually at 20 min during CPB and continued until 6 hours after CPB. gamma-Tocopherol levels followed a similar fashion at the end of CPB. 8-iso-PGF(2alpha) and tocopherol levels kept at basal level 12 and 24 hours post CPB. These findings suggest that an increased free radical-induced oxidative stress together with a gradual appearance of antioxidative defense system during and after CPB.

Cerebral Metabolic Profiling of Hypothermic Circulatory Arrest with and Without Antegrade Selective Cerebral Perfusion

“…Oxidative stress has been demonstrated to be increased during CPB. [ 26 ] The brain is especially susceptible to oxidative stress due to abundant lipid content in myelin sheaths, and antioxidant level has been demonstrated to be related to postoperative delirium in patients undergoing CPB surgery. [ 27 ] Cerebral damage induced by oxidative stress during DHCA attracts lots of attention, and excitatory amino acids were observed to increase significantly after DHCA.…”

Oxidative Stress Response and Delirium after Cardiac Surgery

“…5 The intraoperative increase in plasma F2-isoprostanes reported by Lopez et al is consistent with previous findings. 6 Importantly, these previous studies also reported a concomitant gradual intraoperative increase in circulating antioxidants αand γ-tocopherol. This suggests that an adaptive upregulation of antioxidant counterregulatory response to the oxidative injury associated with CPB is at play.…”