Oxidative stress and damage to erythrocytes in patients with chronic obstructive pulmonary disease — changes in ATPase and acetylcholinesterase activity

Bukowska, Bożena; Sicińska, Paulina; Pająk, Aneta; Koceva‐Chyła, Aneta; Pietras, Tadeusz; Pszczółkowska, Anna; Górski, Paweł; Koter−Michalak, Maria

doi:10.1139/bcb-2015-0066

Cited by 21 publications

(18 citation statements)

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“…On the other hand, high oxidative stress and free radicals can increase AChE activity [ 53 , 54 ]. Dal Forno et al [ 55 ] suggested that an increment in ROS formation and a significant increase in lipid peroxidation could lead to the exposure of the more active sites of the AChE.…”

Section: Discussionmentioning

confidence: 99%

Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic Syndrome after Supplementation with Extract fromAronia melanocarpa

Duchnowicz

Ziobro

Rapacka

et al. 2018

BioMed Research International

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Obesity and metabolic syndrome (MetS) are growing problems among children and adolescents. There are no reports of changes in the activity of butyrylcholinesterase (BChE) in children and adolescents with metabolic syndrome especially after supplementation with extract from Aronia melanocarpa. Materials studied included plasma and erythrocytes isolated from peripheral blood of patients with MetS and healthy subjects. We have estimated the following parameters: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, lipid peroxidation and lipids levels in plasma, and erythrocytes membrane. In patients with MetS, a significant increase in AChE and BChE activity, higher LDL-cholesterol and triacylglycerol levels, and lower HDL-cholesterol level were observed. Supplementation with A. melanocarpa extract resulted in mild but statistically significant reduction of total cholesterol, LDL-cholesterol, and triacylglycerol levels and caused an increase in HDL-cholesterol level and a decrease in lipid peroxidation in plasma patients with MetS. Additionally, a decrease in lipid peroxidation and cholesterol level and a decrease in AChE activity in the erythrocyte membranes after supplementation with A. melanocarpa were noted. Summarizing, an increase in AChE and BChE activity and disruption of lipid metabolism in patients with MetS were observed. After supplementation of MetS patients with A. melanocarpa extract, a decrease in AChE activity and oxidative stress was noted.

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Section: Discussionmentioning

confidence: 99%

Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic Syndrome after Supplementation with Extract fromAronia melanocarpa

Duchnowicz

Ziobro

Rapacka

et al. 2018

BioMed Research International

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“…Indeed, ROS (O°⋅, H 2 O 2 , and OH - ⋅) can inhibit EPO synthesis, by mimicking a false O 2 signal in the renal peritubular interstitial cells. Oxidative stress can also increase the fragility of erythrocytes, decrease the amount of erythroid maturation, and reduce red cell survival ( Sailaja et al, 2003 ; Olszewska et al, 2012 ; Lang et al, 2014 ; Bukowska et al, 2015 ). ROS also mediate the inhibitory effect of proinflammatory cytokines on erythroid precursor proliferation ( Prince et al, 2012 ).…”

Section: Pathogenesis Of Cancer Related Anemiamentioning

confidence: 99%

Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach

Gramignano²,

et al. 2018

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Cancer-related anemia (CRA) is a common sign occurring in more than 30% of cancer patients at diagnosis before the initiation of antineoplastic therapy. CRA has a relevant influence on survival, disease progression, treatment efficacy, and the patients’ quality of life. It is more often detected in patients with advanced stage disease, where it represents a specific symptom of the neoplastic disease, as a consequence of chronic inflammation. In fact, CRA is characterized by biological and hematologic features that resemble those described in anemia associated to chronic inflammatory disease. Proinflammatory cytokine, mainly IL-6, which are released by both tumor and immune cells, play a pivotal action in CRA etiopathogenesis: they promote alterations in erythroid progenitor proliferation, erythropoietin (EPO) production, survival of circulating erythrocytes, iron balance, redox status, and energy metabolism, all of which can lead to anemia. The discovery of hepcidin allowed a greater knowledge of the relationships between immune cells, iron metabolism, and anemia in chronic inflammatory diseases. Additionally, chronic inflammation influences a compromised nutritional status, which in turn might induce or contribute to CRA. In the present review we examine the multifactorial pathogenesis of CRA discussing the main and novel mechanisms by which immune, nutritional, and metabolic components affect its onset and severity. Moreover, we analyze the status of the art and the perspective for the treatment of CRA. Notably, despite the high incidence and clinical relevance of CRA, controlled clinical studies testing the most appropriate treatment for CRA are scarce, and its management in clinical practice remains challenging. The present review may be useful to indicate the development of an effective approach based on a detailed assessment of all factors potentially involved in the pathogenesis of CRA. This mechanism-based approach is essential for clinicians to plan a safe, targeted, and successful therapy, thereby promoting a relevant amelioration of patients’ quality of life.

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“…Our recent study indicated changes in the activity of antioxidant enzymes in COPD patients. We observed an increase in the activity of glutathione peroxidase and a decrease in the activity of superoxide dismutase, but not in the activity of catalase activity [49]. However, Nadeem et al , Gumral et al and Woźniak et al observed changes in activity of all three enzymes – CAT, GSH-PX and SOD [50–52].…”

Section: Discussionmentioning

confidence: 94%

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

Sicińska

Bukowska

Pająk

et al. 2017

aoms

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IntroductionButyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids. Butyrylcholinesterase activity is associated with both inflammation and oxidative stress. Changes in the activity of this enzyme have been observed in various diseases such as liver cirrhosis, diabetes, neurodegenerative disease and others.Material and methodsThe study involved 30 patients with chronic obstructive pulmonary disease (COPD) and 18 healthy subjects. The COPD patients were divided according to the severity of the disease by applying the classification of COPD based on GOLD standards for forced expiratory volume in 1 s (FEV1) and the FEV1/forced expiratory volume (FVC) ratio. The control group comprised blood samples collected from healthy subjects without concomitant diseases related to the respiratory system. Butyrylcholinesterase activity, lipid peroxidation and total antioxidant capacity (TAC) were determined in the blood plasma.ResultsA significant (p < 0.05) decrease in the activity of BChE, associated with an increase in lipid peroxidation and a decrease in the total antioxidant capacity, was observed in blood plasma of patients with chronic obstructive pulmonary disease.ConclusionsThe study shows for the first time that activity of BChE in the blood plasma of patients diagnosed with chronic obstructive pulmonary disease is considerably reduced compared with healthy subjects. These changes were accompanied by a decrease of TAC and an increase of lipid peroxidation, which suggests that they may be related to the oxidative stress induced by COPD disease.

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Oxidative stress and damage to erythrocytes in patients with chronic obstructive pulmonary disease — changes in ATPase and acetylcholinesterase activity

Cited by 21 publications

References 54 publications

Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic Syndrome after Supplementation with Extract fromAronia melanocarpa

Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic Syndrome after Supplementation with Extract fromAronia melanocarpa

Pathogenesis and Treatment Options of Cancer Related Anemia: Perspective for a Targeted Mechanism-Based Approach

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease

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