Oxidative stress and DNA damage in newborns born to mothers with hyperglycemia – a prospective cohort study

Kharidehal, Durga; Adhisivam, B; Ganapathy, Vidya; Bhat, B. Vishnu; Bobby, Zachariah; Chand, Parkash

doi:10.1080/14767058.2017.1344630

Cited by 14 publications

(9 citation statements)

References 10 publications

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“…Alternatively, other negative sensory inputs of reflux or esophagitis may counteract positive sensorimotor circuit stimulation (Wingenfeld and Otte, 2019). Half of the non-responders (3/6) and only one of eight responders were infants of diabetic mothers with poor glucose control during pregnancy, which induces a pro-oxidative state for the mother and fetus known to be associated with immune activation, endothelial cell injury, and worse fetal and neonatal outcomes (Teodoro et al, 2013;Durga et al, 2018). A larger sample size may identify specific predictors for responder status leading to a decrease in variance in treatment response.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study

Badran

Jenkins

Cook

et al. 2020

Front. Hum. Neurosci.

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Neonates born premature or who suffer brain injury at birth often have oral feeding dysfunction and do not meet oral intake requirements needed for discharge. Low oral intake volumes result in extended stays in the hospital (>2 months) and can lead to surgical implant and explant of a gastrostomy tube (G-tube). Prior work suggests pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke, and transcutaneous auricular VNS (taVNS) has emerged as promising noninvasive form of VNS. Pairing taVNS with bottle-feeding rehabilitation may improve oromotor coordination and lead to improved oral intake volumes, ultimately avoiding the need for G-tube placement. We investigated whether taVNS paired with oromotor rehabilitation is tolerable and safe and facilitates motor learning in infants who have failed oral feeding. We enrolled 14 infants [11 premature and 3 hypoxic-ischemic encephalopathy (HIE)] who were slated for G-tube placement in a prospective, open-label study of taVNS-paired rehabilitation to increase feeding volumes. Once-daily taVNS was delivered to the left tragus during bottle feeding for 2 weeks, with optional extension. The primary outcome was attainment of oral feeding volumes and weight gain adequate for discharge without G-tube while also monitoring discomfort and heart rate (HR) as safety outcomes. We observed no adverse events related to stimulation, and stimulation-induced HR reductions were transient and safe and likely confirmed vagal engagement. Eight of 14 participants (57%) achieved adequate feeding volumes for discharge without G-tube (mean treatment length: 16 ± 6 days). We observed significant increases in feeding volume trajectories in responders compared with pre-stimulation (p < 0.05). taVNS-paired feeding rehabilitation appears safe and may improve oral feeding in infants with oromotor dyscoordination, increasing the rate of discharge without G-tube, warranting larger controlled trials.

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Section: Discussionmentioning

confidence: 99%

Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study

Badran

Jenkins

Cook

et al. 2020

Front. Hum. Neurosci.

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“…Oxidative stress due to alloxan induction causes increased ROS levels. Oxidative damage caused by free radicals has implications in various pathological conditions, namely damage to cells, tissues, and organs such as liver, kidneys, pancreas, and heart in both humans and animals [11,12,18]. This damage may cause death or acceleration of the onset of various degenerative diseases.…”

Section: Pancreatic P53 Expressionmentioning

confidence: 99%

“…Intraperitoneal alloxan induction has been shown to cause damage to pancreatic islet cells and the incidence of hyperglycemia preceded by elevated levels of ROS and MDA and followed by an inflammatory reaction [10,11]. ROS and NOS due to exposure to alloxan spur lipid membrane peroxidation and oxidation reactions in proteins and DNA [4,11,12]. Pancreatic islet cell destruction due to exposure to alloxan is characterized by genetic damage (DNA) and elevated MDA levels [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…P53 gene plays an important role in modulating the effect of elevated intracellular ROS or NOS levels, repairing genetic damage and regulating the balance of inflammatory responses [12,16,17]. P53 protein plays a role in stimulating apoptosis in cells undergoing genetic stress due to oxidative stress and inhibiting the inflammatory reaction through suppression of pro-inflammatory transcription factor NF-kappaB.…”

Section: Introductionmentioning

confidence: 99%

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Black Cumin Seed Oil Antidiabetogenic by Increasing Pancreatic P53 Expression

Akrom¹,

Nurfadjrin²,

Darmawan³

et al. 2018

IJPHS

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Black cumin seed oil (BCSO) contains many thymoquinone and unsaturated fatty acids that act as antioxidants. Thymoquinone was thought to inhibit pancreatic damage and prevent hyperglycemia by involving p53. The study aimed to determine the BCSO effect on Malondialdehyde (MDA) levels and p53 expression of pancreatic tissues in alloxan-induced Sprague Dawley (SD) rats. This study used Pre and Post Test with Control Group Design with 49 male Sprague Dawley rats aged 30 days weighing 150 - 300 gram. Rats were divided into 7 groups: Group I, the normal control group receiving standard feeding and drinking; Group II, the negative control group receiving alloxan; Group III & IV, the treatment groups, receiving BCSO with a dose of 6.9 mg/KgBW (BCSO6.8) and 68 mg/KgBW (BCSO68 group); Group V, the positive control 1 group receiving simvastatin 10 mg/KgBW; Group VI, the positive control 2 group receiving vitamin C 18 mg/200mgBW; Group VII, the solvent control receiving DMSO. The treatment groups received two different doses per day for 9 days orally. Blood MDA and glucose levels were determined by spectrophotometry and p53 expression of pancreas tissues were read by a pathologist. The results show that the BCSO68 group had a decreased activity of MDA and glucose but a higher expression of p53 in pancreatic tissues compared to the BCSO6.8 group. Decreased Malondialdehyde levels in the BCSO68 group were similar to those in the vitamin C group but lower than those in the simvastatin group (p<0.05). It can be concluded that the BCSO administration of 68 mg/KgBW per day can decrease blood Malondialdehyde and glucose levels and increase p53 expression.

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“…В результате продемонстрирована положительная корреляция между средним уровнем глюкозы в крови матери и повышенным уровнем повреждений ДНК у потомства [18]. Кроме того, новорожденные у матерей с ГСД имели больший уровень повреждений ДНК в клетках пуповинной крови по сравнению с новорожденными матерей с эугликемией [19].…”

Section: пациенты с гестационным сахарным диабетом (гсд)unclassified

Genotoxic markers in patients with diabetes mellitus (Literature review)

Еремина

Вахитовна²,

Жанатаев

et al. 2021

Ecological genetics

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This paper considers studies aimed at identifying markers of genotoxicity (chromosomal aberrations, micronuclei, and DNA damage assessed by the DNA comet assay) in patients with both gestational diabetes mellitus (GDM) and diabetes type 1 and 2 (T1DM and T2DM, respectively), as well as possible changes in the levels of these genotoxic markers under the influence of medicines and nutritions. Patients with T2DM are characterized by an increased level of genotoxicity markers. The results of genotoxicity markers in patients with T1DM and GDM studies are contradictory, however, they indicate the presence of an increased genotoxic load rather than its absence. The levels of genotoxic damage in diabetic patients may be reduced by physical exercises, diet, and/or hypoglycemic drugs. Metformin, Afobazole and Noopept are recommended for experimental and clinical studies as possible drug candidates that reduce the levels of genotoxic biomarkers in diabetic patients.

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Oxidative stress and DNA damage in newborns born to mothers with hyperglycemia – a prospective cohort study

Abstract: Newborns born to diabetic mothers had increased oxidative stress and DNA damage compared to those born to mothers with euglycemia.

Cited by 14 publications

References 10 publications

Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study

Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study

Black Cumin Seed Oil Antidiabetogenic by Increasing Pancreatic P53 Expression

Genotoxic markers in patients with diabetes mellitus (Literature review)

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