Oxidative stress and its determinants in the airways of children with asthma

Dut, Raziye; Dizdar, Evrim Alyamaç; Birben, Esra; Saçkesen, Cansın; Soyer, Özge; Besler, Halit Tanju; Kalaycı, Ömer

doi:10.1111/j.1398-9995.2008.01766.x

Cited by 94 publications

(81 citation statements)

References 24 publications

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“…Współcześnie wiadomo, iż stres oksydacyjny wiąże się z przebiegiem i/lub etiologią wielu jednostek chorobowych, do których zalicza się m.in. : -choroby neurodegeneracyjne (choroba Parkinsona, choroba Alzheimera, stwardnienie boczne zanikowe, stwardnienie rozsiane) [1,5,16,17,18], -choroby układu sercowo-naczyniowego (miażdży-ca, choroba niedokrwienna serca, nadciśnienie tęt-nicze) [5,7,9,19,20], -choroby nowotworowe [7,9,15,20,21], -choroby metaboliczne (cukrzyca, otyłość) [5,7,18,20,22,23], -choroby atopowe (astma, atopowe zapalenie skóry, alergiczny nieżyt nosa) [8,10,11,24,25,26,27,28,29,30,31,32], -zakażenia bakteryjne, wstrząs septyczny [5,33], -choroby narządu wzroku (zwyrodnienie plamki związane z wiekiem -AMD, jaskra, zaćma) [15], -choroby zapalne (ostre zapalenie trzustki, zapalenie przełyku, zapalenie wątroby) [5,7,15,34].…”

Section: Reaktywne Formy Tlenu I Stres Oksydacyjnyunclassified

“…Wiele współczesnych doniesień naukowych potwierdza ponadto, iż stres oksydacyjny pełni znaczącą rolę w rozwoju i utrzymywaniu przewlekłego procesu zapalnego, jaki ma miejsce w przebiegu AZS, ANN oraz astmy oskrzelowej. Dodatkowo coraz częściej przypisuje się szczególny udział stresu oksydacyjnego w indukcji i zaostrzeniu stanu zapalnego dróg oddechowych (ważny element w patogenezie astmy) [10,11,32,69,73,74]. Źródłem RFT w procesie zapalnym w przebiegu AZS, ANN i astmy oskrzelowej są komórki immunologiczne tworzące naciek zapalny, komórki nabłonka dróg oddechowych i skóry, komórki mięśni gładkich oskrzeli czy komórki śródbłonka naczyń krwionośnych [69,75].…”

Section: Stres Oksydacyjny W Alergiachunclassified

“…Zawartość MDA ocenia się zazwyczaj w surowicy, osoczu, hemolizacie erytrocytów i kondensacie powietrza wydychanego [10,32,35,80]. Ważnymi markerami wykorzystywanymi do oznaczania intensywności procesów oksydacyjnych u astmatyków i osób z AZS są również izoprostany.…”

Section: Stres Oksydacyjny W Alergiachunclassified

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Allergy and Oxidative Stress

Twardoch

Lodwich

Mazur

2016

Ann. Acad. Med. Siles.

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Tlen jako pierwiastek biogenny warunkuje przebieg podstawowych procesów biochemicznych gwarantujących przeżycie komórki. Niestety, w szczególnych warunkach wysoce reaktywne formy tlenu (RFT) mogą wywierać toksyczny efekt na organizm. W niewielkich ilościach RFT są niezbędne do prawidłowego funkcjonowania komórki, jednak ich nasilone wytwarzanie, przekraczające skuteczność działania systemów antyoksydacyjnych, określane mianem stresu oksydacyjnego, sprzyja zaburzeniom struktury i funkcji komórek oraz tkanek. Współcześnie coraz częściej wskazuje się na istotny udział stresu oksydacyjnego w przebiegu i/lub etiologii przewlekłych chorób zapalnych, do których zalicza się m.in. choroby atopowe, takie jak astma oskrzelowa, atopowe zapalenie skóry czy alergiczny nieżyt nosa.stres oksydacyjny, reaktywne formy tlenu, astma oskrzelowa, alergiczny nieżyt nosa, atopowe zapalenie skóry A B S T R A C TOxygen is a biogenic element which determines the course of basic biochemical processes to ensure the survival of the cell. Unfortunately, in particular circumstances, the highly reactive oxygen species (ROS) may cause a toxic effect on the body. Small amounts of ROS are essential for the proper functioning of cells, however, the excessive production of them, which transcend the effectiveness of antioxidant systems -defined as oxidative stress -promotes structural and functional disorders of cells and tissues. Nowadays, the significant participation of oxidative stress is increasingly more frequently indicated in the course and/or etiology of chronic inflammatory diseases, which include atopic diseases such as bronchial asthma, atopic dermatitis, or allergic rhinitis. K E Y W O R D Satopic dermatitis, oxidative stress, reactive oxygen species, bronchial asthma, allergic rhinitis

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Section: Reaktywne Formy Tlenu I Stres Oksydacyjnyunclassified

Section: Stres Oksydacyjny W Alergiachunclassified

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Allergy and Oxidative Stress

Twardoch

Lodwich

Mazur

2016

Ann. Acad. Med. Siles.

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“…Oxidative stress may initiate and augment airway inflammation and may also be resulted from airway inflammation in a positive feedback loop (18), which has been reported to play a causative role in airway inflammation, such as nasal polyps (NPs), asthma, and COPD (19)(20)(21).…”

Section: Pathways Driving Tgf-b1mentioning

confidence: 99%

Transforming growth factor‐beta 1 pathways in inflammatory airway diseases

Yang

Zhang

Feng

et al. 2014

Allergy

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Transforming growth factor-beta 1 (TGF-b1) has been reported being involved in the remodeling and immunosuppression processes of inflammatory airway diseases; understanding the regulation of TGF-b1 is therefore a key to unravel the pathomechanisms of these diseases. This review briefly summarizes the current knowledge on the influencing factors for driving TGF-b1 and its regulatory pathways in inflammatory airway diseases and discusses possible therapeutic approaches to TGF-b1 control. The factors include smoking and oxidative stress, prostaglandins (PGs), leukotrienes (LTs), bradykinin (BK), and microRNAs (miRs). Based on the summary, new innovative treatment strategies may be developed for inflammatory airway diseases with an impaired expression of TGF-b1.The transforming growth factor-beta (TGF-b) superfamily is critically involved in embryonic development, organogenesis, and tissue homeostasis. It acts as multifunctional regulators of cell growth and differentiation and consists of more than 40 members, mainly including TGF-bs, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), activins, and inhibins. Between these superfamily members, there is a complex network of regulatory mechanisms (1, 2).Possessing immunomodulatory and fibrogenic characteristics, TGF-b1 is a pleiotropic and multifunctional cytokine secreted from various types of cells, such as endothelial, epithelial and smooth muscle cells, as well as fibroblasts and most immune system cells.Transforming growth factor-beta 1 regulation is unique because it is targeted to the extracellular matrix as a biologically inactive complex, which consists of a mature 25-kDa polypeptide dimer (TGF-b), a latency-associated protein (LAP), and a latent TGF-b-binding protein (LTBP). Active TGF-b is released from the latent complex that was activated via cleavage by proteases and other molecules. The activated TGF-b then becomes a ligand for TGF-b type I and II receptors, leading to receptor Smad (R-Smad) phosphorylation, which subsequently binds to the common-partner Smad (co-Smad), and becoming Smad complexes. The Smad complexes translocate into the nucleus and combine with several transcription factors, thereby becoming a transcriptional active complex that activates target genes transcription. In Abbreviations AHR, airway hyper-responsiveness; BAMBI, BMP and activin membrane-bound inhibitor; BK, bradykinin; BMP, bone morphogenetic protein; CCL2/MCP-1, chemokine (CC motif) ligand 2/monocyte chemotactic protein-1; COPD, chronic obstructive pulmonary disease; CRS, chronic rhinosinusitis; CysLT, cysteinyl leukotriene; FoxP3, forkhead box P3; LAP, latency-associated protein; LTBP, latent TGF-b-binding protein; miR, microRNA; PG, prostaglandin; RORc, RAR-related orphan receptor C; TGF-b1, transforming growth factor-beta 1.Allergy 69 (2014) 699-707

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“…The shift in the oxidant/antioxidant balance in favor of oxidants is termed "oxidative stress." Oxidative stress contributes to many pathological conditions, including cancer, neurological disorders [4] atherosclerosis, hypertension, ischemia/perfusion [5] diabetes, acute respiratory distress syndrome, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease [6] and asthma [7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Review Article: Oxidative Stress Versus Antioxidants

Al-Dalaen¹

2014

BIO

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Abstract:Oxidative stress is a phenomenon that reflects an imbalance between the production of reactive oxygen species and so-called oxidants, and their elimination by protective mechanisms. These are referred to as antioxidative systems which can detoxify the reactive intermediates, or repair the resulting damage causing toxic effects through the production of peroxides and free radicals that damage all cell components. Further, some reactive oxidative species act as cellular messengers in redox signaling that can cause disruptions in normal cellular signaling mechanisms. In humans, oxidative stress is thought to be involved in the development of atherosclerosis, neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, cancer, diabetes mellitus, inflammatory diseases, as well as psychological diseases or aging processes. It is presently accepted that the reactive oxygen species can be beneficial. Depending on the type of oxidants, intensity and time of redox imbalance, as well as on the type of cells, oxidative stress can play a role in the regulation of other important processes. This is achieved through modulation of signal pathways, influencing synthesis of antioxidant enzymes, repair processes, inflammation, or via the immune system, as a way to attack and kill pathogens. This limits the potential for apoptosis and cell proliferation, and thus affects malignant processes. Imprudent administration of antioxidants may therefore have a negative impact on the organism.

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Oxidative stress and its determinants in the airways of children with asthma

Abstract: Asthma is associated with an extremely powerful oxidative stress not only in the systemic circulation but also in the airways.

Cited by 94 publications

References 24 publications

Allergy and Oxidative Stress

Allergy and Oxidative Stress

Transforming growth factor‐beta 1 pathways in inflammatory airway diseases

Review Article: Oxidative Stress Versus Antioxidants

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