Oxidative stress and metabolic biomarkers in patients with Psoriasis

Abstract

Background: Psoriasis is an autoinflammatory disease that affects not only skin, but multiple organs thus being associated with many comorbidities. Oxidative stress and inflammation play the major role in the pathogenesis of this disease. Studies that examined by-products of oxidative stress in psoriasis show discrepant results. Hence, we aimed to examine the oxidative stress, inflammation and metabolic markers and to explore their potential relationship with disease severity in patients with psoriasis.
 Methods: This case-control study comprised of 35 patients with psoriasis and 35 age, sex and body mass index-matched healthy controls. Metabolic and oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), and catalase (CAT)] were measured. The principal component analysis (PCA) was employed to reduce the number of measured variables into smaller number of factors. 
 Results: Higher AOPP levels (p<0.01) and CAT activity (p<0.001), but no difference in MDA levels in psoriasis patients vs. healthy controls were shown. Multivariate binary logistic regression analysis showed that a combination of metabolic related factor (i.e., glucose and triglycerides) and renal function related factor (i.e., creatinine and urea) was the best model for Psoriasis Area and Severity Index (PASI) >10 prediction, while oxidative stress-hepatic related factor (i.e., MDA, alanine aminotransferase) was selected as the best predictor for Dermatology Life Quality Index (DLQI) >20. 
 Conclusion: Multimarker approach showed that metabolic and renal function related factor and oxidative stress-hepatic related factor were better predictors of psoriasis severity than each single examined biomarker.

Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression

“…Additionally, neutrophils promote increased production of reactive oxygen species [35] and are a major source of antimicrobial proteins [36] and lipocalin 2 [37], further sustaining systemic inflammation. Patients with psoriasis exhibit higher levels of advanced oxidation protein products [38,39] and catalase compared to controls [39], with additional differences between genders [40] supporting once more the need for a tailored therapeutical approach to each patient. Epidermal infiltration of neutrophils, a histopathological marker of psoriasis [41], with consequent activation, leads to the formation of neutrophil extracellular traps (NETs), which further interact directly with keratinocytes and heighten the IL-17A response [42].…”

Analysis of Clinical and Genetic Factors of Obesity and Psoriasis Concomitance—The Influence of Body Mass Composition, Prevalence of Mood Disorders, Environmental Factors and FTO Gene Polymorphisms (rs9939609, rs1558902)

“…Oxidative stress is believed to be a crucial factor in the inflammatory cascade of the pathological mechanism of psoriasis. Bakić et al highlighted the advantages of a multimarker approach, incorporating factors related to metabolism (such as glucose and triglicerydes) and renal function (such as creatinine and urea), which may serve as predictors of psoriasis severity more effectively than individual examined biomarkers [ 52 ].…”

Effects of Different Therapeutic Approaches on Redox Balance in Psoriatic Patients

“…Various cellular structures and molecules are vulnerable to oxidative damage and because of which, oxidative stress is an important link in the development of many diseases. Oxidative stress is recognized as a step in the pathophysiological cascade of psoriasis [ 6 , 15 , 16 ]. An induction of oxidative stress leads to an increased production of IL-23A in human Langerhans-like cells, which is proposed as a mechanism of immunoregulation of cutaneous dendritic cells and an induction of inflammation [ 17 ].…”