Oxidative stress and NFκB activation in the lungs of rats: a synergistic interaction between soot and iron particles

Zhou, Yuhao; Zhong, Caiyun; Kennedy, Ian M.; Leppert, Valerie J.; Pinkerton, Kent E.

doi:10.1016/s0041-008x(03)00157-1

Cited by 93 publications

(74 citation statements)

References 59 publications

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“…These observations indicate that SWCNT particles could activate NF-κB as a result of increased oxidative stress. [17][18][19] As mentioned earlier, a dose-dependent increase in oxidative stress by SWCNT was observed and this increase is correlated with the activation of the NF-κB in HaCaT cells (Figures 1 and 4). For the first time, there are data to suggest that SWCNT particles are capable of inducing NF-κB in a dose-dependent manner in HaCaT cells.…”

Section: Activation Of Nf-κb By Swcnt Particles In Hacat Cellssupporting

confidence: 73%

Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-κB in Human Keratinocytes

et al. 2005

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Carbon nanotubes are now becoming an important material for use in day to day life because of their unique physical properties. The toxicological impact of these materials has not yet been studied in detail, thereby limiting their use. In the present study, the toxicity of single-walled carbon nanotubes (SWCNT) was assessed in human keratinocyte cells. The results show increased oxidative stress and inhibition of cell proliferation in response to treatment of keratinocytes with SWCNT particles. In addition, the signaling mechanism in keratinocytes upon exposure to SWCNT particles was investigated. Results from the study suggest that SWCNT particles activate NF-κB in a dosedependent manner in human keratinocytes. Further, the mechanism of activation of NF-κB was due to the activation of stress-related kinases by SWCNT particles in keratinocytes. In conclusion, these studies show the mechanism of toxicity induced by SWCNT particles.

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Section: Activation Of Nf-κb By Swcnt Particles In Hacat Cellssupporting

confidence: 73%

Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-κB in Human Keratinocytes

et al. 2005

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“…Animals exposed to soot particles at a concentration of 250 µg/m 3 and to iron alone at a concentration of 57 µg/m 3 had no adverse respiratory effects, but a synergistic interaction between soot and iron particles, in the combined exposure, was identified with strong inflammatory responses (Zhou et al, 2003).…”

Section: Pm: Carbon and Ironmentioning

confidence: 95%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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“…The method for preparing lung cytosolic and nuclear protein extracts has been previously described (Zhou, et al, 2003;Zhong, et al, 2006). Briefly, immediately following deep anesthesia of the rats, the right lung was removed, frozen in liquid nitrogen, and stored in −80°C…”

Section: Preparation Of Lung Cytosolic and Nuclear Protein Extractmentioning

confidence: 99%

NF-κB inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats

Zhong

Zhou

Pinkerton

2008

Toxicology and Applied Pharmacology

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Apoptosis is a vital mechanism for the regulation of cell turnover and plays a critical role in tissue homeostasis and development of many disease processes. Previous studies have demonstrated the apoptotic effect of tobacco smoke; however, the molecular mechanisms by which tobacco smoke triggers apoptosis remain unclear. In the present study we investigated the effects of tobacco smoke on the induction of apoptosis in the lungs of rats and modulation of nuclear factor-kappa B (NF-κB) in this process. Exposure of rats to 80 mg/m 3 tobacco smoke significantly induced apoptosis in the lungs. Tobacco smoke resulted in inhibition of NF-κB activity, noted by suppression of inhibitor of κB (IκB) kinase (IKK), accumulation of IκBα, decrease of NF-κB DNA binding activity, and downregulation of NF-κB -dependent anti-apoptotic proteins, including Bcl-2, Bcl-xl, and inhibitors of apoptosis. Initiator caspases for the death receptor pathway (caspase 8) and the mitochondial pathway (caspase 9) as well as effector caspase 3 were activated following tobacco smoke exposure. Tobacco smoke exposure did not alter the levels of p53 and Bax proteins. These findings suggest the role of NF-κB pathway in tobacco smoke-induced apoptosis.

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Oxidative stress and NFκB activation in the lungs of rats: a synergistic interaction between soot and iron particles

Cited by 93 publications

References 59 publications

Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-κB in Human Keratinocytes

Single-Walled Carbon Nanotube Induces Oxidative Stress and Activates Nuclear Transcription Factor-κB in Human Keratinocytes

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

NF-κB inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats

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