Oxidative stress and the enzyme system of aldehyde catabolism in the muscle mitochondria of immobilized pubertal rats

Hamdallah, Amjad; Davydov, Roman; Shvets, V. N.

doi:10.15407/ubj86.06.050

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“…Вплив хімічних речовин на мітохондрії може викликати їх дисфункції та бути причиною загибелі клітини в цілому (Begriche et al, 2011;Brinkmann et al, 2013;Buron et al, 2017). Особливо чутливі до несприятливих умов серед клітинних органел мітохондрії пе-чінки, де відбуваються процеси біотрансформації ендогенних і екзогенних метаболітів, які утворюються не тільки у печінці, а і в інших органах і тканинах (Gergalova and Skok, 2011;Melnichuk et al, 2013;Hamdallah et al, 2014). Порушення функцій мітохондрій може бути причиною миттєвого печінкового ци-толізу та стеатозу (Dykens et al, 2007;Labbe et al, 2008;Vadzuk et al, 2010).…”

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The effect of biologically active feed additives of humilid substances on the antioxidant system in liver mitochondria of gerbils

Dyomshina

Ушакова

Stepchenko

2017

Regul. Mech. Biosyst.

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Mitochondria are organelles that are most sensitive to the action of stressors on any cell of the entire organism and exposure to chemicals which can cause its dysfunction and cell death in general. Especially sensitive to adverse conditions are liver mitochondria, where the processes of biotransformation of endogenous and exogenous metabolites are formed, not only in the liver, but also in other organs and tissues. Mitochondrial dysfunction can cause instant hepatic cytolysis and steatosis. Therefore, early detection of mitochondrial toxicity is important during preclinical studies of new pharmacological agents, as this will help avoid remote negative effects. The biologically active feed additive Humilid, a complex of humic acids known for their antidiarrheal, analgesic, immune-stimulating, and antimicrobial properties; shows a corrective effect on the activity of the lysosomal cathepsin; enhances the positive effect of hematopoiesis on hemoglobin and its quality indicators consisting of red blood cells; and activates the synthesis and accumulation of fibronectin expression that takes part in the formation of immunological protection of animals. The objective of our experiment was to determine the effect of complex biologically active feed additives based on humic substances on the biochemical indicators of the liver mitochondrial antioxidant system of Mongolian gerbils (Meriones unguiculatus Milne-Edwards, 1867). The experiment was conducted on mature (6 months) Mongolian gerbils. The data obtained showing the influence of the biologically active feed additives Humilid, alone or in combination with ascorbate and Eco-impulse Animal, on the antioxidant defense system of liver mitochondria of gerbils are presented in this article. The proven antioxidant effect of humic substances in the mitochondrial fraction of the liver which inhibits the accumulation of oxidized products in the cells is shown, confirmed by the decrease in the number of TBA-active products, catalase activation, and an increase in the concentration of cytochrome C. Also, an increase in the amount of cytochrome C, which is a direct participant in the mitochondrial respiratory chain and provides efficient electron transport, indicates the acceleration of energy supply processes. The functional activity of mitochondria was accompanied by increased activity of aspartate aminotransferase involved in the shuttle of malateaspartate transport of electrons through the mitochondrial membrane. The results obtained indicate the positive reaction of gerbil liver mitochondria under the influence of the biologically active feed additives of humic substance.Keywords: Humilid; ascorbic acid; Eco-impulse Animal; aspartate aminotransferase; catalase; superoxide dismutase; TBA-active products; cytochrome C Вплив біологічно активних кормових добавок гумінової природи на систему антиоксидантного захисту мітохондрій печінки монгольської піщанки О. О. Дьомшина*, Г. О. Ушакова*, Л. М. Степченко** *Дніпровський національний університет імені Олеся Гончара, Дніпро, Украї...

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