2024
DOI: 10.3390/cells13131081
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Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility

Peter Artimovič,
Zuzana Badovská,
Silvia Toporcerová
et al.

Abstract: Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a constant threat to this delicate balance. Oxidative stress induces a reciprocally regulated nuclear factor erythroid 2-related factor 2/peroxisome proliferator-activated receptor-gamma (Nrf2/PPARγ) pathway. However, increased PPARγ activity appears to be a double-edge… Show more

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