Oxidative stress as a bio-marker of estrogen exposure in healthy veal calves

Brambilla, G; Ballerini, A.; Civitareale, Cinzia; Fiori, Maurizio; Neri, Bruno; Cavallina, R.; Nardoni, A; Giannetti, Luigi

doi:10.1016/s0003-2670(02)01400-9

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…Measurement of d-ROMs in blood has been reported as indicative of oxidative stress (Ridker et al, 2004) and already used as an oxidative stress index in human, calves and pigs (Cornelli et al, 2001;Ballerini et al, 2003;Brambilla et al, 2003). In this study, B pigs had lower d-ROMs levels than LW pigs regardless of their housing environment, which is in agreement with the hypothesis of a better redox status in rustic slow-growing pigs relative to fast-growing pigs (Brambilla et al, 2002).…”

Section: Discussionsupporting

confidence: 87%

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Merlot

Vincent

Thomas

et al. 2012

Animal

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Since decades, production traits such as growth rate, feed efficiency or body composition have been drastically increased in pigs by genetic selection. Whether this selection impacted animal robustness is still unclear. In this study, we compared Large White (LW) pigs, a breed submitted to intense genetic selection for production traits, and Basque (B) pigs, a local rustic breed, reared in two different housing environments (conventionalv.enriched). Adaptation to housing conditions among each breed was evaluated at the level of endocrine and immune traits. These are known to be impacted by housing conditions and breed; however, the interaction effects between genotype and environment are less described. Animals (20 per breed and housing environment) entered the experiment at 35 kg of live weight. Levels of cortisol, acute-phase inflammatory proteins, immunoglobulins and hydrogen peroxide, blood formula, lymphocyte proliferation andin-vitrocytokine expression were measured at ∼115 kg of live weight. Animals were checked for skin injuries during the growing period. At slaughter, at the average live weight of 145 kg, carcasses were examined for pathological conditions of the respiratory tract. The major result was that the two breeds exhibited differences in response to the housing environment. Among the 24 sanitary, endocrine or immune traits investigated, the housing conditions affected eight variables in both breeds (salivary cortisol at 0700 and 1900 h, severity of pneumonia at slaughter) or only in B pigs (severe skin lesions) or LW pigs (salivary cortisol at 1500 h, granulocyte numbers and lymphocyte/granulocyte ratio and lymphocyte proliferation). These observations strengthen the hypothesis that selection for high meat production level might be associated with an increased susceptibility of animals to environmental stressors.

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Section: Discussionsupporting

confidence: 87%

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Merlot

Vincent

Thomas

et al. 2012

Animal

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“…Intracellular ROS formation was measured by a colorimetric method based on the Fenton reaction [7]. ROS kit was purchased from the Nanjing Bioengineering Institute, China.…”

Section: Reactive Oxygen Species (Ros) Contents and Antioxidant Enzymmentioning

confidence: 99%

Ultraviolet-B exposure induces photo-oxidative damage and subsequent repair strategies in a desert cyanobacterium Microcoleus vaginatus Gom.

Xie

Wang

Liu

et al. 2009

European Journal of Soil Biology

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“…Intracellular ROS formation was measured by a colorimetric method based on the Fenton reaction (Mohamadin, 2001;Brambilla et al, 2003). ROS kit was purchased from the Nanjing Bioengineering Institute, China.…”

Section: Detection Of Intracellular Ros Production and Lipid Peroxidamentioning

confidence: 99%

Growth and antioxidant system of the cyanobacterium Synechococcus elongatus in response to microcystin-RR

Liu

et al. 2005

Hydrobiologia

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Microcystins, one type of the cyanobacterial toxins, show a broad range of hazardous effects on other organisms. Most of the researches on the toxic effects of microcystins have involved in animals and higher plants. Little work, however, has been done on evaluating the mechanisms of microcystin toxicity on algae. In this study, the toxicological effects of microcystin-RR (MC-RR) on the cyanobacterium Synechococcus elongatus were investigated. For this purpose, six physio-biochemical parameters (cell optical density, reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST)) were tested in algal cells when exposed to 100 lg )1 microcystin-RR. The results showed that the growth of Synechococcus elongatus (expressed as optical density) was significantly inhibited compared with the control. At the same time, the treated algae exhibited a pronounced increase in production of ROS and MDA after 6 days exposure to microcystin-RR. Significant changes in GSH levels and GSH-Px, GSH activities were also detected in algal cells, with higher values being observed in the toxin treated algae after 6 days exposure. GST activities in the treated algae exhibited a decline after exposure and rapid augmentation on day 3, thereafter, they kept at a high level when compared to the control group. GSH contents and GSH-Px activities were also significantly raised in the toxin-treated algae cells from day 3, but they showed a sharp decrease on day 4, which was the onward of cell proliferation. These results suggested that oxidative stress manifested by elevated ROS levels and MDA contents might be responsible for the toxicity of microcystin to Synechococcus elongatus and the algal cells could improve their antioxidant ability through the enhancement of enzymatic and non-enzymatic preventive substances.

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Oxidative stress as a bio-marker of estrogen exposure in healthy veal calves

Cited by 22 publications

References 14 publications

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Ultraviolet-B exposure induces photo-oxidative damage and subsequent repair strategies in a desert cyanobacterium Microcoleus vaginatus Gom.

Growth and antioxidant system of the cyanobacterium Synechococcus elongatus in response to microcystin-RR

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