Oxidative stress biomarkers and paraoxonase 1 polymorphism frequency in farmers occupationally exposed to pesticides

Costa, Chiara; Gangemi, Silvia; Giambò, Federica; Rapisarda, Venerando; Caccamo, Daniela; Fenga, Concettina

doi:10.3892/mmr.2015.4196

Cited by 35 publications

(32 citation statements)

References 34 publications

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“…In addition, we found that also the maternal PON1 Q192R genotype affected the associations. Mothers carrying the R‐allele may detoxify some pesticides more slowly and have reduced antioxidative capacity to protect against lipid oxidation, resulting in a more unhealthy metabolic profile (Aviram et al ., ; Macharia et al ., ; Costa et al ., ). This might result in a more adverse intrauterine environment affecting metabolic programming.…”

Section: Discussion With Conclusionmentioning

confidence: 97%

Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X‐ray absorptiometry (DXA)

et al. 2016

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SUMMARYMany modern pesticides have endocrine disrupting abilities and early-life exposure may affect growth and disease risk later in life. Previously, we reported associations between prenatal pesticide exposure and higher childhood body fat content measured by anthropometry. The associations were affected by child PON1 Q192R genotype. We aimed to study whether prenatal pesticide exposure was still associated with body fat content and distribution in the children at puberty and the potential impact of both maternal and child PON1 Q192R genotype. In this prospective cohort study of 247 children born by occupationally exposed or unexposed women (greenhouse workers and controls) two follow-up examinations (age 10-15 and 11-16 years) including simple anthropometry, skinfold measurements, pubertal staging and blood sampling were performed. Total and regional fat% was determined by dual X-ray absorptiometry (DXA) at age 10-15. Prenatal pesticide exposure was associated with increased total, android, and gynoid fat percentage (DXA) at age 10-15 years after adjustment for sex, socioeconomic status, and puberty (all b = 0.5 standard deviation score (SDS) p < 0.05). Stratified by sex, the associations were significant in girls (total fat: b = 0.7 SDS, android-gynoid ratio: b = 0.1, both p < 0.05), but not in boys. Carrying the R-allele (child or mother, separately, or both) augmented the differences between exposed and unexposed children (total fat: b = 1.0 SDS, b = 0.8 SDS, p < 0.05, respectively, and b = 1.2 SDS, p < 0.01). No exposure-related differences were found if either the child or mother had the QQ wild-type. At age 11-16, exposed children tended to have a higher total fat% estimated by skinfolds than unexposed children (p = 0.06). No significant associations between prenatal exposure and body mass index or waist circumference were found. Prenatal pesticide exposure was associated with higher adolescent body fat content, including android fat deposition, independent of puberty. Girls appeared more susceptible than boys. Furthermore, the association depended on maternal and child PON1 Q192R genotype.

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Section: Discussion With Conclusionmentioning

confidence: 97%

Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X‐ray absorptiometry (DXA)

et al. 2016

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“…Pesticides are varied in terms of the structure and usage of chemical substances, their main purpose being to provide protection against pests [6]. The use of pesticides causes environmental pollution and accidental exposure of certain groups of people to their harmful effects [7].…”

Section: Discussionmentioning

confidence: 99%

Pesticide poisonings in 2004−2014 in Łódź, Poland − an analysis of selected clinical and sociodemographic parameters

Krakowiak

Zajdel

Kobza-Sindlewska

et al. 2019

Med Pr

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Background: Acute pesticide poisonings constitute an important toxicological problem in numerous countries. This report refers to patients treated for poisonings at the Toxicology Unit, Łódź, Poland, in the period 2004−2014. Material and Methods: Data to be analyzed were obtained from medical records of hospitalized people. A group of 24 301 patients aged ≥ 15 were selected. In the group of 149 people poisoned with pesticides (0.61% of all poisoning cases), there were 40 women and 109 men. Logistic regression analysis was used to evaluate the impact of age on suicide attempts using pesticides. Results: Suicide attempts significantly more frequently concerned younger people. In this type of behavior, coumarin derivatives were significantly more often used than organophosphorus compounds or pesticides classified as "others. " The patients with suicidal pesticide poisonings stayed in the ward significantly longer than those poisoned unintentionally. Conclusions: In the analyzed population inhabiting an area with a high degree of urbanization, in terms of the place of residence and employment, pesticide poisonings were more common in men than in women. Suicide attempts using pesticides more frequently concerned younger people. Information found in this study may prove useful for education purposes, and also in informing clinicians. Med Pr. 2019;70(6):655-67

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“…PON1 activity varies significantly among individuals, and several molecular variants of this enzyme are recognised. Pesticide exposure and the consequent oxidative stress both have an impact on PON1 gene polymorphisms (60), and research has indicated that an epigenetic mechanism may be responsible for these alterations (61,62). …”

Section: Epigeneticsmentioning

confidence: 99%

Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans

Gangemi

Miozzi

Teodoro

et al. 2016

Molecular Medicine Reports

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141

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It is well known that pesticides are widely used compounds. In fact, their use in agriculture, forestry, fishery and the food industry has granted a huge improvement in terms of productive efficiency. However, a great number of epidemiological surveys have demonstrated that these toxic compounds can interact and exert negative effects not only with their targets (pests, herbs and fungi), but also with the rest of the environment, including humans. This is particularly relevant in the case of workers involved in the production, transportation, preparation and application of these toxicants. Accordingly, a growing body of evidence has demonstrated the correlation between occupational exposure to pesticides and the development of a wide spectrum of pathologies, ranging from eczema to neurological diseases and cancer. Pesticide exposure is often quite difficult to establish, as many currently used modules do not take into account all of the many variables that can occur in a diverse environment, such as the agricultural sector, and the assessment of the real risk for every single worker is problematic. Indeed, the use of personal protection equipment is necessary while handling these toxic compounds, but education of workers can be even more important: personal contamination with pesticides may occur even in apparently harmless situations. This review summarises the most recent findings describing the association between pesticide occupational exposure and the development of chronic diseases.

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Oxidative stress biomarkers and paraoxonase 1 polymorphism frequency in farmers occupationally exposed to pesticides

Cited by 35 publications

References 34 publications

Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X‐ray absorptiometry (DXA)

Prenatal pesticide exposure and PON1 genotype associated with adolescent body fat distribution evaluated by dual X‐ray absorptiometry (DXA)

Pesticide poisonings in 2004−2014 in Łódź, Poland − an analysis of selected clinical and sociodemographic parameters

Occupational exposure to pesticides as a possible risk factor for the development of chronic diseases in humans

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