Oxidative stress does not contribute to the release of proinflammatory cytokines through activating the Nod-like receptor protein 3 inflammasome in patients with obstructive sleep apnoea

Tang, Tingyu; Huang, Qingdong; Liu, Juan; Zhou, Xiaoxi; Du, Jing; H, Wu; Li, Zhijun

doi:10.1007/s11325-018-1726-3

Cited by 16 publications

(13 citation statements)

References 27 publications

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“…As shown in Table 1 , of the 63 studies retained for analysis, 14 were conducted in China ( 27 , 39 , 46 , 50 , 51 , 54 , 55 , 58 , 65 , 73 , 77 , 81 , 82 , 86 ), eight in the USA ( 26 , 28 , 34 , 38 , 56 , 76 , 78 , 83 ), six in Greece ( 37 , 43 , 47 , 49 , 58 , 64 ), six in Japan ( 29 – 31 , 41 , 42 , 44 ), six in Turkey ( 12 , 57 , 62 , 67 , 68 , 70 ), three in Italy ( 59 , 63 , 87 ), 3 in Brazil ( 45 , 53 , 72 ), three in Spain ( 36 , 60 , 71 ), two in Sweden ( 66 , 84 ), two in India ( 79 , 85 ), one in Ireland ( 32 ), one in Germany ( 35 ), one in Thailand ( 40 ), one in Finland ( 48 ), one in Canada ( 52 ), one in the UK ( 74 ), one in Croatia ( 80 ), one in Australia ( 33 ), one in Taiwan ( 69 ), and one in Belgium ( 75 ). With regard to ethnicity, 28 studies were performed with Caucasians ( 12 ,…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

et al. 2020

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Obstructive sleep apnea syndrome (OSAS) is considered a low-grade chronic inflammatory disease. Interleukin-6 (IL-6) is one of the most significant inflammatory markers and an excellent proxy for the inflammatory/immune system. The present meta-analysis and meta-regression aimed at comparing plasma and serum levels of IL-6 between individuals (children and adults) with OSAS and healthy controls. Four databases, PubMed/Medline, Scopus, Cochrane Library, and Web of Science, were comprehensively searched to retrieve articles published up to December, 2019, with no further restrictions. RevMan 5.3 software was used to calculate the crude mean difference (MD) and 95% confidence interval (CI). The results of funnel plots and meta-regression were analyzed by the CMA 2.0 software. Sixty-three studies (57 with adults; six with children) were included in the present meta-analysis. For adults, 37 studies reported significantly higher serum IL-6 levels and 20 reported significantly higher plasma IL-6 levels for those with OSAS than for healthy controls [pooled MD of 2.89 pg/ml ( P < 0.00001) and pooled MD of 2.89 pg/ml ( P < 0.00001), respectively]. The pooled analysis of serum and plasma IL-6 levels in children with OSAS compared with controls revealed that only the MD of plasma IL-6 levels was significant (MD = 0.84 pg/ml, P = 0.004). Results of the meta-regression showed that greater age was associated with higher serum IL-6 levels. Egger's test revealed a publication bias across the studies for serum and plasma IL-6 levels ( P = 0.00044 and P = 0.01445, respectively). In summary, the meta-analysis and meta-regression confirmed that, compared to healthy controls, individuals with OSAS (children and adults) had higher serum/plasma IL-6 levels.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

et al. 2020

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“…However, no increase in NLRP3 expression was found in either the muscles in OSA or in hypoxic cells at the protein level, suggesting possible negative posttranscriptional modulation in C2C12 cells. However, the serum levels of the NLRP3 inflammasome are not different between OSA patients and healthy controls [37]. The kidneys of NLRP3 −/− mice are protected from OSA-induced injury and oxidative stress [38].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have demonstrated increased ROS levels and higher oxidative stress in OSA [5, 6, 37]. Oxidative stress was previously shown to mediate the pyroptosis of cardiomyocytes, macrophages, and neuronal cells [18–20].…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-Induced ROS Contribute to Myoblast Pyroptosis during Obstructive Sleep Apnea via the NF-κB/HIF-1α Signaling Pathway

Zhang

Han

et al. 2019

Oxidative Medicine and Cellular Longevity

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Tissue hypoxia caused by upper airway collapse is a main cause of excessive oxidative stress and systemic inflammation in obstructive sleep apnea (OSA) patients. Increased reactive oxygen species (ROS) and inflammatory responses affect cell survival and ultimately contribute to tissue injury. In the present study, we proposed that the induction of ROS by hypoxia, as an intrinsic stress, activates myoblast pyroptosis in OSA. We found increased cell death and abnormal expression of pyroptosis markers in the skeletal muscle of OSA mice. In vitro studies showed hypoxia-induced pyroptotic death of C2C12 myoblasts, as evidenced by the activation of caspase-1 and gasdermin D (GSDMD). Hypoxia induced ROS overproduction and accumulation in myoblasts. More importantly, applying N-acetylcysteine (NAC), an ROS scavenger, rescued cell swelling, downregulated the inflammatory response, and prevented pyroptotic death in hypoxia-cultured myoblasts. Hypoxia stimulation promoted NF-κB P65 phosphorylation and HIF-1α nuclear translocation. Moreover, hypoxia increased the nuclear level of cleaved caspase-1 and GSDMD. NAC inhibited hypoxia-induced variations in the HIF-1α and NF-κB signaling pathway. Taken together, our results determined that hypoxia-induced ROS contribute to myoblast pyroptosis. Therefore, our findings suggest that ROS may be a potential therapeutic target for ameliorating hypoxia-induced cell death and tissue injury, especially in OSA and hypoxia-related diseases.

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“…Among adult participants, eighteen studies were performed with Caucasians [ Table 1 presents the characteristics of the 55 studies included in the meta-analysis. Forty-six studies [16,[28][29][30][31][32][33][34][35][36][38][39][40][41][43][44][45][46][47][48][49][50][51][52]54,[56][57][58][59][60][61][62][63][64][65][67][68][69][70][71][72]75,76,[78][79][80] reported serum or plasma TNF-α concentrations in adults, and nine studies [14,37,...…”

Section: Search Strategiesmentioning

confidence: 99%

“…Among adult participants, eighteen studies were performed with Caucasians [31,34,36,[39][40][41][46][47][48][49]59,61,63,65,68,69,75,80], nineteen sampled Asians [16,29,32,33,35,43,45,52,54,58,60,62,64,67,71,72,76,78,79], and nine samples mixed [28,30,38,44,50,51,56,57,70] ethnicities. For studies with adult samples, 29 out of 46 studies reported serum TNF-α concentrations [16,[31][32][33]…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Imani

Sadeghi

Khazaie

et al. 2020

Life

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Background: Obstructive sleep apnea syndrome (OSAS) is associated with a variety of inflammatory factors. Specifically, proinflammatory cytokines appear to be associated with the pathogenesis of OSAS. Methods: For the present meta-analysis and meta-regression on serum and plasma tumor necrosis factor alpha (TNF-α) levels in individuals with and without OSAS, we performed a systematic search without any restrictions of the PubMed/Medline, Scopus, Cochrane Library, and Web of Science databases to find relevant articles published up to 1 February 2020. Results: Fifty-five (adults: 29 studies on serum and 17 studies on plasma; children: 4 studies on serum and 5 studies on plasma) were included and analyzed. Always compared to age-matched healthy controls, the pooled MDs were as follows: adults, serum: 10.22 pg/mL (95% CI = 8.86, 11.58; p < 0.00001); adults, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001); children, serum: 0.21 pg/mL (95% CI = 0.05, 0.37; p = 0.01); children, plasma: 5.90 pg/mL (95% CI = 4.00, 7.80; p < 0.00001). Conclusions: Compared to healthy and age-matched controls, adult individuals with OSAS had significantly higher serum/plasma TNF-α levels. For children with OSAS, significantly higher levels were observed for TNF-α in serum but not in plasma.

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Oxidative stress does not contribute to the release of proinflammatory cytokines through activating the Nod-like receptor protein 3 inflammasome in patients with obstructive sleep apnoea

Cited by 16 publications

References 27 publications

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

Hypoxia-Induced ROS Contribute to Myoblast Pyroptosis during Obstructive Sleep Apnea via the NF-κB/HIF-1α Signaling Pathway

Serum and Plasma Tumor Necrosis Factor Alpha Levels in Individuals with Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression

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