Oxidative stress gene polymorphisms may have an impact in the development of ischemic stroke

Abstract

It is unlikely that CAT and GPX1 single nucleotide polymorphisms are risk factors for IS. The results of the present study show that smoking may be a risk factor for IS risk in patients with MnSOD mutant genotypes.

Knockdown of PVT1 Exerts Neuroprotective Effects against Ischemic Stroke Injury through Regulation of miR-214/Gpx1 Axis

“…Sharma et al found that Gpx1 silencing promoted the proinflammatory response and activated vascular endothelium [ 19 ]. Moreover, Karahalil et al reported that Gpx1 served as a risk factor for ischemic stroke [ 20 ], indicating that Gpx1 might be involved in the development of ischemic stroke.…”

Superoxide imbalance triggered by Val16Ala‐SOD2 polymorphism increases the risk of depression and self‐reported psychological stress in free‐living elderly people

“…Furthermore, the following three co-variables were also considered despite a lack of specific associative studies between them and Val16Ala-SOD2 polymorphism: hypertension, smoking, and polypharmacy. Previous reports describe an association between the Val16Ala-SOD2 SNP and cardiovascular diseases (Flores et al, 2017;Fujimoto, Kobayashi, Ogasawara, Yamakado, & Ohno, 2010;Fujimoto et al, 2008;Kakko et al, 2003;Karahalil, Elkama, & Orhan, 2017;Souiden et al, 2016), for which hypertension and smoking habits are important risk factors. Regarding polypharmacy, consistent evidences exist supporting an association between certain pharmacological drugs and body weight modulation, including antidepressants (Abosi, Lopes, Schmitz, & Fiedorowicz, 2018) and antipsychotic drugs, which are sometimes prescribed to depressive elderly patients (Dayabandara et al, 2017).…”

Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease

“…GPX1 and MnSOD are located on chromosomes 3p21 and 6q25, respectively. Commonly studied genetic polymorphisms on these enzymes are GPX1 Pro198Leu and MnSOD Ala16Val , and these gene polymorphisms may decrease MnSOD and GPX1 activities; so they possibly increase susceptibility to oxidative stress 25 . For the XRCC1 enzyme, which is thought to be effective in neurological disorders, three most widely studied polymorphisms have been identified and may be functionally relevant.…”

“…Commonly studied genetic polymorphisms on these enzymes are GPX1 Pro198Leu and MnSOD Ala16Val, and these gene polymorphisms may decrease MnSOD and GPX1 activities; so they possibly increase susceptibility to oxidative stress. 25 For the XRCC1 enzyme, which is thought to be effective in neurological disorders, three most widely studied polymorphisms have been identified and may be functionally relevant. Of the three polymorphisms, it was shown that XRCC1 Arg399Gln might reduce the efficiency of the repair process by changing a conserved amino acid in the binding domain of PARP or polynucleotide kinase (PNK).…”