Oxidative stress in air pollution research

Mudway, Ian; Kelly, Frank J.; Holgate, Stephen T.

doi:10.1016/j.freeradbiomed.2020.04.031

Cited by 76 publications

(54 citation statements)

References 45 publications

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“…Over the past decade, accumulating evidence suggests that ROS and oxidative stress are involved in PM 2.5 -mediated cardiovascular injury. 45 The mitochondrion is a sensitive target of oxidative stress as well as environmental toxicants stimulus like PM 2.5 . 46,47 In contrast to the rather robust evidence base supporting the upregulation of ROS pathways in response to PM 2.5 exposure, the regulation and expression of antioxidant defenses are relatively sparse.…”

Section: Discussionmentioning

confidence: 99%

Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Jiang

Liang

Zhang

et al. 2020

Journal of Pineal Research

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Fine particulate matter (PM 2.5) exposure is correlated with the risk of developing cardiac fibrosis. Melatonin is a major secretory product of the pineal gland that has been reported to prevent fibrosis. However, whether melatonin affects the adverse health effects of PM 2.5 exposure has not been investigated. Thus, this study was aimed to investigate the protective effect of melatonin against PM 2.5-accelerated cardiac fibrosis. The echocardiography revealed that PM 2.5 had impaired both systolic and diastolic cardiac function in ApoE-/mice. Histopathological analysis demonstrated that PM 2.5 induced cardiomyocyte hypertrophy and fibrosis, particularly perivascular fibrosis. While the melatonin administration was effective in alleviating PM 2.5-induced cardiac dysfunction and fibrosis in mice. Results of electron microscopy and confocal scanning laser microscope confirmed that melatonin had restorative effects against impaired mitochondrial ultrastructure and augmented mitochondrial ROS generation in PM 2.5-treated group. Further investigation revealed melatonin administration could significantly reverse the PM 2.5-induced phenotypic modulation of cardiac fibroblasts into myofibroblasts. For the first time, our study found that melatonin effectively alleviates PM 2.5-induced cardiac dysfunction and fibrosis via inhibiting mitochondrial oxidative injury and regulating SIRT3-mediated SOD2 deacetylation. Our findings indicate that melatonin could be a therapy medicine for prevention and treatment of air pollution associated cardiac diseases.

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Section: Discussionmentioning

confidence: 99%

Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Jiang

Liang

Zhang

et al. 2020

Journal of Pineal Research

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“…These effects include respiratory (asthma, chronic obstructive pulmonary disease, pneumonia) and cardiovascular (enhanced thrombosis, elevated arterial blood pressure, and enhanced atherosclerosis) morbidity and premature mortality [ [3] , [4] , [5] ]. Furthermore, recent studies have shown that exposure to ambient air pollution is associated with increased oxidative stress that is the primary cause for the aforementioned morbidities, and may lead to additional morbidities such as diabetes and cancer [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic exposure to ambient air pollutants on COVID-19 morbidity and mortality - A lesson from OECD countries

Barnett-Itzhaki

Levi

2021

Environmental Research

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“…Ambient air pollution is pollution that exists in the environment, which can come from human activities, or takes place, naturally, in nature (38). Air pollution can be caused by human activities in the aspect of industrial activities, motor vehicles (39), households, energy generation, agriculture, and the shipping sector (40).…”

Section: Discussionmentioning

confidence: 99%

“…NO 2 ambient air pollution is able to influence student education assessment in schools on the short term (50), and in chronic exposure that NO 2 pollutants cause inflammation in the lungs (51). Exposure to ambient air pollution in the long term can lead to premature death and increase the morbidity in the worldwide (38).…”

Section: Discussionmentioning

confidence: 99%

“…Air pollution in Beijing can cause individuals to be attacked by Chronic Obstructive Pulmonary Disease (COPD) (42). However, there is not enough evidence to state that air pollution can cause fundamental indications of chronic disease in general, such as the presence of various responses through oxidative stress and inflammation (38). In addition, air pollution (NO 2 , NOx, PM 2,5 , and PM 10 ) can has an impact on fetal growth in utero (41).…”

Section: Discussionmentioning

confidence: 99%

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The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

Nasikhah

Pawitra

2020

JKL

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Introduction: WHO has announced coronavirus Disease 2019 (Covid19) as a global pandemic at the immune decline, one of which is due to chronic exposure to ambient air pollution. This literature review aims to describe the impact of ambient air pollution toward the risk of being infected by Covid19. Discussion: Covid19 can be found in a bat (host primer), and can be contagious through a person, also possible from pets. The symptoms that sufferers will perceive are fever, cough, diarrhea, myalgia, fatigue, headache, nausea, vomit, abdominal pain, loss of appetite, and some asymptomatic people. The body’s immunity affects a person’s susceptibility to Covid19 infection. The body’s immunity can be affected by ambient air pollution (with PM10, PM2,5, and O3 are the most pollutant in the air in various countries) for an extended period could be the reason for chronic illness (especially, respiratory tract) could reduce immune resistance. Furthermore, it might be happened on increasing at ACE2 activity and can cause increasing infected by Covid19. Prevention action can be done by contributing from all of the sectors at an observance in guarding, physical distancing, quarantine, and maintaining the ambient air quality in the future. Conclusion: Ambient air pollution must be considered as one effort to prevent chronic illness that can reduce immunity, which can increase the risk of being infected with Covid19. Furthermore, future studies will be carried out on ACE2 activity in people infected with Covid19 in order to get more valid results and following current conditions.

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Oxidative stress in air pollution research

Cited by 76 publications

References 45 publications

Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Effects of chronic exposure to ambient air pollutants on COVID-19 morbidity and mortality - A lesson from OECD countries

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

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Oxidative stress in air pollution research

Cited by 76 publications

References 45 publications

Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Effects of chronic exposure to ambient air pollutants on COVID-19 morbidity and mortality - A lesson from OECD countries

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

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Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Melatonin ameliorates PM_2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis