Oxidative stress in immunocompetent patients with severe community-acquired pneumonia. A pilot study

Trefler, Sandra; Rodríguez, Alejandro; Martín‐Loeches, Ignacio; Sanchez, Vanesa C.; Marin, J. J. G.; Llauradó, M.; Romeu, Marta; Dı́az, Emili; Nogués, Rosa; Giralt, Mireia

doi:10.1016/j.medin.2013.01.004

Cited by 27 publications

(18 citation statements)

References 38 publications

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“…Moreover, alveolar glutathione peroxidase concentrations were lower in VAP. Trefler et al16 showed that TBARS levels were higher in CAP patients than in controls. Katsoulis et al17 evaluated the total antioxidant status (TOS) of 30 patients with CAP.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Parlak

Alışık

Hezer

et al. 2018

SMJ

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ObjectivesTo compare dynamic thiol/disulfide homeostasis between patients with community-acquired pneumonia (CAP) and healthy controls.MethodsThis prospective, case-control study was conducted in the Department of Pulmonary Diseases, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey, between August 2016 and August 2017. In total, 50 hospitalized patients with CAP and 35 healthy individuals were enrolled. Patients with comorbidities and smokers were excluded. The thiol/disulfide state was evaluated in each group. Thiol levels (native/total) and % polymorhonuclear leukocytes and C-reactive protein levels association were evaluated in patients with CAP.ResultsThere was no significant difference between the CAP and control groups in age or gender (both, p>0.05). The disulfide (SS) levels were similar between the 2 groups (p=0.148). The total thiol (TT) and native thiol (SH) levels were significantly lower (all, p=0.001) and the SS/TT levels were significantly higher (p=0.019) in the CAP group compared with the controls.ConclusionsThis study showed that the oxidant/antioxidant ratio was shifted to the oxidative side in CAP patients. An abnormal thiol/disulfide state may be an important factor in the pathogenesis and monitoring the treatment response. The thiol resources may use for treatment in CAP and may positively affect the prognosis.

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Section: Discussionmentioning

confidence: 98%

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Parlak

Alışık

Hezer

et al. 2018

SMJ

View full text Add to dashboard Cite

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“…Numerous studies have shown that there was a higher oxidative stress in CAP patients compared with healthy volunteers. [ 26 ] The effects of oxidative stress in the airway as well as in other organs depend on ROS concentration and time of exposure. In general, higher levels of ROS produce damage in biomolecules (e.g., lipid peroxidation) and induce intracellular signaling pathways leading to cell death, mainly through apoptosis.…”

Section: Discussionmentioning

confidence: 99%

N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia

Zhang

et al. 2018

Medicine

117

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Oxidative stress is considered to be part of the pathogenic mechanism for community-acquired pneumonia (CAP) and is closely linked to inflammation. Attenuation of oxidative stress would be expected to reduce pulmonary damage. Antioxidants have been found to be effective in alleviating lung injury and protecting against damage of other organs.The aim of the study was to compare the effect of adding N-acetylcysteine (NAC) to conventional treatment versus conventional treatment on oxidative stress, inflammatory factors, and radiological changes in CAP patients.Eligible CAP patients at Weihai Municipal Hospital were stratified and randomly assigned to either NAC group or non-NAC group between August 2016 and March 2017. The NAC group received conventional treatment for pneumonia and NAC (1200 mg/d). Thenon-NAC group received conventional therapy. malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant capacity (TAOC), tumor necrosis factor-α (TNF-α), and computed tomography (CT) images were evaluated at baseline and after treatment. The primary endpoint indicators were the changes in oxidative stress parameters (MDA, TAOC, SOD) and TNF-α after treatment in the NAC group compared with those in the non-NAC group. The secondary endpoint indicator was any difference in CT scores after treatment in the NAC group compared with the non-NAC group.Baseline levels of MDA, TAOC, SOD, and TNF-α were similar between the 2 groups before treatment. Plasma levels of MDA and TNF-α decreased more (P < .05 MDA:p 0.004, TNF-α:p <0.001) in the NAC group than the non-NAC group, and there was a reliable increase in TAOC content (p 0.005). There was no significant difference in increased plasma SOD activity between the groups (p 0.368), and the NAC group did not show a greater improvement from CT scores. No NAC-related adverse effects were observed.Addition of NAC therapy for CAP patients reduced MDA and TNF-α and increased TAOC. Treatment with NAC may help to reduce oxidative and inflammatory damage in pneumonia patients.

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“…Based on derived results the author concludes that leading factors in CAP belongs to disorder in immunity function and peroxide homeostasis [ 1 ]. The change in enzyme activity of antioxidant protection was found also in pilot research which had been made by Trefler S. et al [ 2 ].…”

Section: Introductionmentioning

confidence: 67%

Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity

Muravlyova¹,

Molotov-Luchankiy²,

Bakirova³

et al. 2016

Open Access Maced J Med Sci

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BACKGROUND:At the present time the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in the development and progression of community-acquired pneumonia (CAP). However the nature and direction of the oxidative protein changes in CAP patient’s blood had been almost unexplored.AIM:To define oxidative and modified proteins in erythrocytes and blood plasma of CAP patients.MATERIAL AND METHODS:Blood plasma and erythrocytes obtained from: 42 patients with moderate severity pneumonia, 12 patients with grave severity pneumonia and 32 healthy volunteers. Content of advanced oxidation protein products, malondialdehyde and reactive carbonyl derivatives were estimated as indicators of the oxidative stress and oxidative damage of proteins.RESULTS:In patients with grave severity the level of oxidative proteins and MDA in erythrocytes exceeded both: control values and similar meanings in CAP patients with moderate severity. The further growth of MDA in this group patients’ blood plasma was observed, but the level of oxidative proteins decreased in comparison with those in CAP patients with moderate severity.CONCLUSION:To sum up, our derived data show, that injury of erythrocytes’ redox-status and blood plasma components plays an essential role in development and progression CAP.

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Oxidative stress in immunocompetent patients with severe community-acquired pneumonia. A pilot study

Cited by 27 publications

References 38 publications

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

Evaluation of dynamic thiol/disulfide redox state in community-acquired pneumonia

N-acetylcysteine improves oxidative stress and inflammatory response in patients with community acquired pneumonia

Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity

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