Oxidative Stress in Painters Exposed to Low Lead Levels

Mohammad, Imran Khan; Mahdi, Abbas Ali; Raviraja, Aryapu; Islam, Najmul; Ahmad, Iqbal; Venkatesh, Talavara

doi:10.2478/10004-1254-59-2008-1883

Cited by 47 publications

(42 citation statements)

References 44 publications

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“…The treatment with bromelain did cause a significant reduction of Pb accumulation in the kidney and spleen, however, in the liver there was no detectable change observed due to bromelain treatment. The levels of serum MDA, a biomarker of metal-induced lipid peroxidation, were significantly increased in the groups exposed to both low and high doses of Pb in comparison to the control group which are consistent with the earlier studies [15,16]. Bromelain effectively reduced the MDA levels in the group exposed to a lower dose of lead.…”

Section: Discussionsupporting

confidence: 81%

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Al-Otaibi¹,

Virk²,

Elobeid³

2015

Acta Biologica Hungarica

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The present study investigates the protective efficacy of stem bromelain against lead-induced toxicity in male Wistar rats. There were six experimental groups; Group I was negative control, Group II was administered only 20 mg/kg of stem bromelain. Group III and V were orally exposed to 30 mg/kg/day and 60 mg/kg/day of lead acetate, respectively. Group IV and Group VI were exposed to both low and high dose of lead acetate, respectively, and treated with 20 mg/kg stem bromelain. The experimental period was 21 days. The end points evaluated were, lead accumulation in kidney, liver and spleen, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, serum malonaldehyde (MDA) cholesterol and triglycerides levels. Co-administration of stem bromelain with lead markedly reduced the lead accumulation in the kidney and spleen. The treatment of stem bromelain also reduced the serum MDA levels in the group exposed to lower dose of lead and serum triglyceride level in the group exposed to higher dose of lead. The lead-induced modulated levels of serum ALT and AST were also alleviated by bromelain treatment. Our key findings suggest a chelating potential of stem bromelain for combating lead toxicity and oxidative stress. Bromelain represents a novel approach to the treatment of metal toxicity and metabolic disorders with a limited therapeutic window.

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Section: Discussionsupporting

confidence: 81%

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Al-Otaibi¹,

Virk²,

Elobeid³

2015

Acta Biologica Hungarica

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“…Generation of highly reactive oxygen species (ROS) aftermath of lead exposure may result in systematic mobilization and depletion of the cell intrinsic antioxidant defenses [Patra et al, 2011]. The results of this study support the hypothesis; since there was a signifi cant increase in the level of MDA and a signifi cant decrease in the endogenous antioxidants following intake of Pbacetate [Mohammad et al, 2008;Haleagrahara et al, 2011;Aziz, 2012]. This was explained by the high affi nity of lead for sulfhydryl (SH) group in several enzymes such as SOD, GSH and GPx; thus it can alter antioxidant activities by inhibiting functional SH groups in these enzymes as these enzymes are potential targets of lead toxicity [Marchlewicz et al, 2007].…”

Section: Discussionsupporting

confidence: 78%

Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice

Makawy¹,

Ashoush²,

Abd-El-Moneim³

2015

Pol. J. Food Nutr. Sci.

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The antioxidant and antiproliferative properties of mango by-products were investigated. This study was carried out to evaluate the protective role of mango peel or kernel defatted extracts against Pb-acetate adverse effects on oxidant/antioxidant status, liver dysfunction biomarkers, histopathological changes and genotoxicity in male mice. Total phenolic content and antioxidant activity of both extracts were evaluated. Two doses of both extracts (50 and 100 mg/kg) were used to evaluate their role against the toxicity of Pb-acetate (500 ppm). Mice given mango extracts with Pb-acetate had signifi cantly lower plasma MDA, AST and ALT and higher glutathione than mice given Pb-acetate alone. Mango extracts prevented the histopathological changes in liver induced by Pb-acetate and decreased the cytotoxicity of lead by increasing the ratio of PCE/NCE. Mango extract treatment reduced the DNA damage induced by Pb-acetate in liver as demonstrated by a reduction in micronuclei and decrease in tail length, tail DNA% and Olive tail moment. It can be concluded that mango by-product extracts have potential to protect from oxidative stress and genotoxicity of lead.Unauthenticated Download Date | 5/8/18 7:04 AM

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“…The decrease in CAT activity might be due to the inhibition of haembiosynthesis of catalase by lead (Patil et al 2006). Mohammad et al (2008) have also reported that decrease in CAT activity was due to lead toxicity.…”

Section: Methodsmentioning

confidence: 96%

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

et al. 2011

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Lead poisoning has been known to be associated with structural and functional abnormalities of multiple organ systems of human body. The aim of this investigation was to study the renal protective effects of ginger (Zingiber officinale) extract in lead induced toxicity rats. In this study renal glutathione (GSH) level, glutathione peroxidase (GPX), glutathione-s-transferase (GST), and catalase enzymes were measured in lead nitrate (300 mg/kg BW), and lead nitrate plus ginger extract (150 mg/kg BW) treated rat groups for 1 week and 3 weeks respectively. The glutathione level and GSH dependent antioxidant enzymes such as glutathione peroxidase, glutathione-stransferase, and catalase significantly (P<0.05) increased in ginger extract treated rat groups. In addition, histological studies showed lesser renal changes in lead plus ginger extract treated rat groups than that of lead alone treated rat groups. These results indicate that ginger extract alleviated lead toxic effects by enhancing the levels of glutathione, glutathione peroxidase, glutathiones-transferase and catalase.

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Oxidative Stress in Painters Exposed to Low Lead Levels

Cited by 47 publications

References 44 publications

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Evaluation of Mango Byproduct Extracts as Antioxidant against Pb-acetate induced Oxidative Stress and Genotoxicity in Mice

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats

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